<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16557

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEEGLDVDDLFGDPNGLDLGLPTAQPTKGLAQRLDEMRLLGCCRKIAWSRLGCIAYISQDGLQVIVRHLVCNPTDGKWGLTEEYSQNQIAQLHLGQQLLHLCWNETGSDLAVLDASGRISILSIPAALNSLGVSRQTVVDPPDDGSQVVGMMWMNSNRAVHAFHQAAKLNGRWNYSPYRRKPIGPFHPAGKPALICFTRNGIMRLLYQNPDQRWAEVSAELKTTNQSDRILTHAACLPSPNGILVATHSLSEKLSLYRVQIMWNPPQWDQAQQRQASGVLPFPVPSIRISHCKTEIPGRVFSFNKDQAEELQNIAPNQSFLYQLTNLELVSGQFDNTGATTSPPWILAVYSSPFNSAGHDPQQQEPPASVMVRWQLETSTINLHPVFEESLSKKANGQQRTKLEIRRMEDIHFDKHVVSIDQIEFGCVLAVTHDDSSVSFFDPKSMSQFNEGGDVNTVTSMGQAGFRFPSDTPALNICFSPNSCLAVVLDTDWQAQLRIADFNFEPEGDLHEGKNSNGIIALALTFSRGCAIEYNADDLIMTISRHLSTDAQNVFVNEVYRALPINCNFSMEQDKPMQHPYVPRCLSLQAALGFQSFQTPRGLPYSVPWAVLHLRHASLLFAFFFQYSKQPKENETLDHDVLQMVYGNTKWALDFTQYLLDDLFALAKEFEPVLDDQEALAQKVKTTSSLSLTLVLATSPFAGDGRAYSKELYALIDSAPVRFNVYEKFLNSVESAIKNAYQRAGFGDDERRTPEKDLLVNSRIPAVMIPVIVSLFKQTIPTIQTEIDQMSIYLTDYSWLGFCSDRRTEHFRRTRAVDIVKKVPLRGFNLSNNIIEPNITSQITSNGNKAGPSSRRRCVRCCEITGDPSSPRSMLYFQLTLRLQLIRNCLCGGMWTFEDGPPTPAATHKQVG
Length912
PositionTail
OrganismPenicillium sp. 'occitanis'
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.09
Grand average of hydropathy-0.269
Instability index45.26
Isoelectric point5.96
Molecular weight102071.75
Publications
PubMed=28951729

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16557
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.67|      45|     100|     412|     511|       1
---------------------------------------------------------------------------
  422-  468 (73.61/47.85)	QIEF..GCVLAVTHDDSSVSFfdPKSMSQFNEGGDVNTV.TSMG.QAGFRF
  523-  571 (64.06/87.46)	ALTFsrGCAIEYNADDLIMTI..SRHLSTDAQNVFVNEVyRALPiNCNFSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.70|      33|      40|     637|     675|       3
---------------------------------------------------------------------------
  637-  675 (47.63/43.21)	LDhdvlQMVygNTKWALDFTQYLLDDLF.....ALAKEFEPVLD
  680-  717 (47.07/26.72)	LA....QKV..KTTSSLSLTLVLATSPFagdgrAYSKELYALID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.38|      32|     104|     720|     751|       8
---------------------------------------------------------------------------
  720-  751 (55.40/36.04)	PVR.FNVYEKFLN.SVESAIKNAYQRAGFGDDER
  824-  857 (45.99/28.73)	PLRgFNLSNNIIEpNITSQITSNGNKAGPSSRRR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16557 with Med16 domain of Kingdom Fungi
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