<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16546

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDSSPLAGNVSPSSFSVSNLKANCSPGISDNLYPHTPTSPPLMSVGAQNYASNFAHTNTSPSHTTTSNGQLLSSPPSSTPMSTQNSQQPTVSVTASFPTPASSVSGHPRNTTPADESELADKSWGQGPQNSHATSNTDFGNADKSGHRRTDHDRHRLPVGFDMEGRPSATDVDMMDIDSKADNSTPRDSSLDALQQDIGTAFHLCKTVPTITGPDPSFDLISLYGLGPIGRSVMRADPTTGEKINRLRKSYEGKLKGLGLSGRNKAVKNENQAGGLRHLMMWPEEEWQIQKVHGKEIKVAEAESALQKLQMRAMKLEAGPLPNSEYWEDILGHEKPSKHTAFESGKRAVSTPNALRPTVQANGVPATAAAPERARPTRGKKRHYDDNSFVGYGEGFVDDEDEGALYSNSEDRSGKKKRKKVFNLVVYLFRQRS
Length434
PositionHead
OrganismPenicillium sp. 'occitanis'
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.805
Instability index43.22
Isoelectric point7.81
Molecular weight47027.49
Publications
PubMed=28951729

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP16546
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     100.61|      18|      19|     107|     124|       1
---------------------------------------------------------------------------
  107-  124 (31.66/15.31)	GH.PRNTTPADESEL..ADKS
  126-  146 (19.77/ 7.22)	GQgPQNSHATSNTDFgnADKS
  147-  162 (27.60/12.55)	GH.RR..TDHDRHRL..PVGF
  166-  181 (21.58/ 8.44)	GR.P.SATDVDMMDI..DSK.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.89|      15|      19|      67|      83|       3
---------------------------------------------------------------------------
   67-   83 (24.61/18.56)	TSNGQ.....LLSSPPssTPMS
   84-  103 (22.29/10.33)	TQNSQqptvsVTASFP..TPAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.01|      22|      38|     284|     305|       4
---------------------------------------------------------------------------
  284-  305 (38.41/23.94)	PEEE.WQIQKVHGKEIKVAEAES
  323-  345 (36.60/22.53)	PNSEyWEDILGHEKPSKHTAFES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16546 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GHEKPSKHTAFESGKRAVSTPNALRPTVQANGVPATAAAPERARPTRGKKRHYD
2) NCSPGISDNLYPHTPTSPPLMSVGAQNYASNFAHTNTSPSHTTTSNGQLLSSPPSSTPMSTQNSQQPTVSVTASFPTPASSVSGHPRNTTPADESELADKSWGQGPQNSHATSNTDFGNADKSGHRRTDHDRHRLPVGFDMEGRPSATDVDMMDIDSKADNSTPRDSSLDALQQ
333
24
386
197










Molecular Recognition Features






MoRF SequenceStartStop




1) KKKRKKVFNLVVYLFRQRS
416
434