<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16543

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLILDNPMPVELNDVDDLFGDGVGLSLPARAQSKQLQQRMDDVRIRGCCQTVAWSRTGTIANITPDGQNLELRFLRRSPEDGSWDLSEPTTCPFVKGLPTIPIVHLVWAGTSSPDLAVIDAVGRVSIVSFSISLNHPFPQRKWDADPTDDVHAVVGAYWLNVSPPNQQASYNVMYGPATKHGNGYTYESSFVHAGGPTHPSPAKSALLTITTHGVIRMFWSQNTNRLEETTMELESISASDELITHASFASEKKHLLLAVATTSKQLKLIKIEIQWGQASQADKATGRPAGNLSPSLVEKHLATTNWLQGGPGDSSLDISMIELSHLEVLPSVVDSTGKNTTPPMVVTARSRTPTESSYQGSQSVVDRWEAIEQKQNLPSAYEQLGGRRNSISSELPAVTQLQKVAPVTANKVVVAFQTTSFGKILVLAFADGTVEYRDRLTFEELYTTQELNKVQNLRQIGWTFTDEGPCQQVAFSPTFCSMVQMGEDGKIKWNKLHYPMGDIGNSMHDAQYCGSIAALTVTAAPSMFYQNNYDDLLAIVRPYTTKKRFVQDLVTELIRILKIQIDYSEEIHHDSLVRNGSLQYCLSIMNALGFRGDFHPRSFQGKFSMLFLNVRNVVVLITIASNTPVTVREKLSPLDDPEVIETLVGCARWALDLIAWLMDCLFELMNDNHFQELLTRERFHELAPYLHEKNNVAFHFLMSSSSRGFLSAICRRLAHLEALSGRAIEFYRKQSAVVEGVAGGRAAPQLQQAYQAMQQVTSSALVKVSEVETLLTGLSNEIRQAYQIFLPSLAKSQNNQSQGKQLDMTMKAARVQMELSILLSAAPPAPFLQIIKKFFNTDLPAFRNTVNPGRLFFANYDLLEVEDDEHSLAAKKARGMVYVDVFKRMQIRPSPNKQWRRCSRCTAVMEDVFGSRSGFTFVLGQQRKCSCGGQWTLLPKGHVA
Length946
PositionTail
OrganismFusarium oxysporum f. sp. radicis-cucumerinum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex.
Aromaticity0.08
Grand average of hydropathy-0.201
Instability index47.65
Isoelectric point6.66
Molecular weight105185.78
Publications
PubMed=27387256
PubMed=28831051

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16543
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.12|      14|     230|      75|      88|       1
---------------------------------------------------------------------------
   75-   88 (27.56/16.96)	FLRRSPEDGSWDLS
  308-  321 (27.56/16.95)	WLQGGPGDSSLDIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.32|      14|      19|     530|     543|       2
---------------------------------------------------------------------------
  530-  543 (24.36/16.79)	FYQNNYDDLLAIVR
  551-  564 (21.96/14.46)	FVQDLVTELIRILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.28|      26|     180|     676|     747|       5
---------------------------------------------------------------------------
  394-  419 (41.38/ 7.40)	SSELPAVTQLQKVAPVTANKVVVAFQ
  676-  701 (45.91/95.70)	FQELLTRERFHELAPYLHEKNNVAFH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.59|      40|      53|     202|     241|       8
---------------------------------------------------------------------------
  175-  196 (25.38/13.70)	........................MYGPATKHGNGYTYESSFVHAG
  202-  241 (64.62/47.47)	SPAKSALLTITTHG......VIRMFWSQNTNRLEETTMELESISAS
  252-  297 (56.59/40.55)	SEKKHLLLAVATTSkqlkliKIEIQWGQASQADKATGRPAGNLSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.56|      17|      30|     740|     757|       9
---------------------------------------------------------------------------
  740-  757 (25.74/20.85)	VEGVAGGrAAPQLQQAYQ
  773-  789 (28.82/18.05)	VETLLTG.LSNEIRQAYQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16543 with Med16 domain of Kingdom Fungi
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