<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16541

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSDPAGEIVHITQGYIPLSKVLTRLAQSTHNALQDQIAALAKMPLPAAAMNGNSTVLNSDVEDGSGENIAKKTSILNFAMREHRKWVKALVITEWSRKADMVSKLIDLRFHLQGQEVLFSGALDVMGHVKRDLTFARMPSPDLKTALQVLSTGEAAWMPDLSYIEPPPLTRQEQIQWISDLDTQLSLRLNLEDFDKIPYHFRNYEIDSGRVTFKVAGEFEVDLTIADEDFEKQFWFIDFRFAFEPAASSIPDGLKNYLEGQVNDILSKDGLLGCYQFLHELVLTHKLNELKRQAIQLSRGSWTGTLKVEPLNRALAIQYWTSRAQLGSPKSWILIAVNSGRKPNGQPDPKSSSHLMAKWYRDNKEVKDTNISFDADNLSAETLMKTVIGRHVEFLLGSIHSRLQAFPRFQNRDAAMILNISHDDPATSFLSMQVGYKDSASLLVEPTTGVFAVKPHSKFTIQHEHLLNNGKNPADDGATCLENVRCGVMEDELIRRGSTTGWNTKKSPLSKDELRSLTNTREWTKTIWLQRTGWDPNWFVMVMLSPSGDAWWLVDASRNANGQSNRLSSKLPLNKGYPHLEDEFWNNLTLFATGMIAQAVDQHELYRQNIKFLLQDTRNWSLPQQVRLPTLEISLSDIFPSMVFNMAEKDNAKAANESNAGTETARLGPVAPTASTPGISTRQPWAHDIVSIRFKGVEPVDKEASGAGGPISDVSFMCISDAIIKVRKPTKFAMLKGHMVGRDVSWKARTGEFCLRMRSNIGLSILENLKARVKAVDRFVSFFESLDKARGFIKAESVSLKEVTFSYGPPASQTVEDAEVSRLWRVALNLSNNDIDIQVQETNPHLPVTDLMQKLVNGANGIGALMDWLPASLPTMEAFKKIREAWSDIEARRQGRFKFIMNSTDEMSFQYLLAGTGPGNQQVQRSITFLGQIKQRRGEPWWHIERKIPSSGWPSLNDEFSAALKPVWDGKGDDWSGLVTGATGRPENGIIGLLLAIDEAIRPLAGSTFQNNSEVVILE
Length1019
PositionTail
OrganismFusarium oxysporum f. sp. radicis-cucumerinum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex.
Aromaticity0.08
Grand average of hydropathy-0.329
Instability index33.09
Isoelectric point6.44
Molecular weight114075.50
Publications
PubMed=27387256
PubMed=28831051

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16541
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.09|      44|     425|     533|     587|       1
---------------------------------------------------------------------------
  537-  581 (75.66/65.37)	NWFVMVMLSPSGDAWWLVDASRNANGQSNRlSSKLPLNKGYPHLE
  589-  632 (75.44/36.18)	TLFATGMIAQAVDQHELYRQNIKFLLQDTR.NWSLPQQVRLPTLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     254.89|      86|     425|       3|      97|       2
---------------------------------------------------------------------------
    3-   97 (127.40/100.01)	DPAGEIVHITQGYI........PLSKVltrLAQSTHNALQDQIAAL...AKMPlpaaAMNGnSTVLNSdVEDGSGEN.IAKKTSILNFAMRE...HRKWVKALVIT.EWSR
  424-  525 (127.49/76.59)	DPATSFLSMQVGYKdsasllvePTTGV...FAVKPHSKFTIQHEHLlnnGKNP....ADDG.ATCLEN.VRCGVMEDeLIRRGSTTGWNTKKsplSKDELRSLTNTrEWTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     163.22|      66|     144|     103|     179|       3
---------------------------------------------------------------------------
  103-  179 (93.18/91.09)	SKLIDLRFHLQGQEVLFS.GALDVMGHVKRDLTFA.........................................................rmpspDLK.TALQvLSTGeaAWMPDLSyIEppPLTRQEQIQ.WIS
  192-  226 (36.98/15.28)	EDFDKIPYHFRNYEIDSGrVTFKVAGEFEVDLTIA......................................................................................................
  289-  322 (33.06/14.22)	...................................dedfekqfwfidfrfafepaassipdglknylegqvndilskdgllgcyqflhelvlthklnELKrQAIQ.LSRG..SWTGTLK.VE..PLNRALAIQyWTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.57|      32|      52|     861|     892|       5
---------------------------------------------------------------------------
  861-  892 (56.87/34.43)	GIGALMDWLPASLPTMEAFKKIR.EAWSDIEAR
  915-  947 (55.70/33.57)	GTGPGNQQVQRSITFLGQIKQRRgEPWWHIERK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16541 with Med14 domain of Kingdom Fungi
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