<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16537

Description Uncharacterized protein
SequenceMGAHPRPPQRSVSSSSLPVQRPPPQRSLSHQQQFMAAASPVRKDAPFIDLTADAGDATPNRYHTTPRRGGSRLRLELSHNASSSSLPTSESPQSLTPSRIPNSDPFQAMVGSPPGSASSTLMPMPTRRPVTSQPRFAPRITATAPAPAKKDARPKPYTVEIPSVAPRYFSANRPETAVRNPVDPFSKGLNSGYADFFPWNGAHHEDEWSSEAITKGTWDKVNLNVPETSSAKLAIFPALKQKTGLNALSTIFMGVLTQRRHRGQINAPSTFKPPPRVTLTDTKREVWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKNVPAERAVWLAKCVGANEIRGLKRKGVNGAFVMGGELKWARDWTVFVEQFVDAVVAGFGENDWKNRVTYAIRLATNLYSEQLLDRDHYLDWVVSGIENSLQSRIPMWLLIAQIYWKDLLRSRKYGRRLVFALLSHLHVISNDPDQDLLVQLSSRLSALLGSLIRSNPESFINPGAWSTYKDTLHACLRSDDEQARKALHAINSRNSRLVVSSTASPPAGRSQLVKLLDAALKESSDNHLAAACWATSENKSLIMKTVVEWATSFHRPGLAKVYAATRLIRQWSQFRVNPTTPILETLDNIAANDKARKNLVYHLVTELVRTGHFSVSQYMQWTIARGGYHCAAEIDPVSGPCSSRLLVELPLHVLSEKKRAERGNLLRRAGNYSVAEEEQDITNAIRVVKHVVGLPLPSNDPLSGRKPMSLKKLLQRMGGSSTALRSSIGAHLRDELTGQFIMKGHSLSLTMFTAVRDIMEMAEDYAMLSDILGACAKTADSDVLASVADTVHSNLQIFCALDSANELFNSLIERLRMMNEEQRLVPRPLLAALSSLAQRMAGHEVIASQLRQELVQNDRNNAIDACSPVSDIVATPSHQAENNVAEEVERTLSSGTRLDPPTMNKLFRMIIPALERGWEKEDDTRRVFATLLARIRVFDAHHFDKLMTDWTSHIRSISNRSSLSTLFPLLIITGCLTMPIIMSTASPPFANIQNLAPESSRGPATYLQELLQLVIMPLPQATGLVAEESYRFHTEQKCAKFEQSKGLLNLVRNALLEYSTVRNHVNGTEFPLDNLECQESLLETLRTLVLVDSSAVSNALGIKSLPAEAVGLVRKVTTKLLIPGDSGETQISFDHILQIANELTLPFCQLKLNLDLSLPQPSVIEGQDQSSSRFEIFARAMDRAIEAGNIMWTSLLPCLSDDITQHLKTQAQTGFLDLIPSSKAPEFVDTGSRQSLRMAENLLEVVEAIISGQAPPKMAQLSLGMVEKLTDLWEIVAAGPQERPNCHAAVLQHWLPAMLRFVNLHSLSSEPPSAPLPTASATRPPIPPVHDVRARIVLVLCGLLLELETLPPATVGSLVQQVFDIAILLVDALPEELRANCARATLLTPGGMPNQGTSSDPRLYYLFSSPPPSPSDNLMLSHREKAATPQSAAARGMGAQYGIGPVVQERLSPFILRRWEVLSEPTPNVGENDTSLSLGLFEAIKLQ
Length1519
PositionKinase
OrganismFusarium oxysporum f. sp. radicis-cucumerinum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex.
Aromaticity0.06
Grand average of hydropathy-0.205
Instability index52.49
Isoelectric point8.80
Molecular weight167397.79
Publications
PubMed=27387256
PubMed=28831051

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP16537
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     272.10|      92|     101|     762|     862|       1
---------------------------------------------------------------------------
  728-  778 (31.26/23.79)	......................................................LP..SNDPLSgrkpMSLKKLL.QRMGGSS..TALRSSIGAHLrDELTGQfiMKGHS
  779-  876 (138.89/111.34)	LSLTMFTAVRDimEMAEDYAMLSDILGACAKTADSDVLASVADTVHSNLQifcaLD..SANELF....NSLIERL.RMMNEEQ..RLVPRPLLAAL.SSLAQR..MAGHE
  882-  964 (101.95/65.80)	LRQELVQNDRN..NAIDACSPVSDIVATPSHQAENNVAEEVERTLSSGTR....LDppTMNKLF....RMIIPALeRGWEKEDdtRRVFATLL.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.78|      27|     101|       7|      34|       2
---------------------------------------------------------------------------
    7-   31 (35.75/20.37)	.........PPQrSVS.SSSLPVQRPPPQRSLSHQ
   32-   53 (25.18/ 8.91)	QQF.............mAAASPVRKDAPFIDLTAD
  104-  133 (37.85/17.53)	DPFqamvgsPPG.SAS.STLMPM...PTRRPVTSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.65|      12|     101|    1336|    1347|       4
---------------------------------------------------------------------------
 1336- 1347 (23.23/11.01)	LHSLSSEPPSAP
 1435- 1446 (25.43/12.82)	LYYLFSSPPPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.61|      33|      93|    1287|    1323|       6
---------------------------------------------------------------------------
 1287- 1323 (56.55/46.86)	PPKmaqlSLG.MVEKLTDL.WEIVAAGPQE.RPNCHAAVL
 1383- 1418 (45.06/27.70)	PPA....TVGsLVQQVFDIaILLVDALPEElRANCARATL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.58|      28|      34|     381|     409|      12
---------------------------------------------------------------------------
  381-  409 (45.07/32.58)	ENDWKNRVTYAIrLATNLYSEQLLDRDHY
  418-  445 (50.51/31.94)	ENSLQSRIPMWL.LIAQIYWKDLLRSRKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.64|      17|      34|    1087|    1103|      15
---------------------------------------------------------------------------
 1087- 1103 (29.97/22.18)	LLEYSTVRNHVNGTEFP
 1122- 1138 (26.66/18.80)	LVDSSAVSNALGIKSLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16537 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MGAHPRPPQRSVSSSSLPVQRPPPQRSLSHQQQFMAAASPVRKDAPFIDLTADAGDATPNRYHTTPRRGGSRLRLELSHNASSSSLPTSESPQSLTPSRIPNSDPFQAMVGSPPGSASSTLMPMPTRRPVTSQPRFAPRITATAPAPAKKDARPKPY
1
157










Molecular Recognition Features






MoRF SequenceStartStop




1) ARPKPYTVEI
2) FIDLTA
3) PRITA
4) RLYYLF
152
47
138
1434
161
52
142
1439