<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16530

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETSEYETNTLSINNIASITFRIYEPPPDQSHGFQSSALEIQSSLRDQGKLVSYDADRVGIWIFQIVSKDGTSKAVNSAPGSSLEASGYTLGMVEEGNLEPVALQKSRIPGNTTQNAPNNTASTASPAEANSRNPLISPTQVAGGALPEGVSQSSAQVTDMRTTQPVPKIIYEQFIVAVISSIAFAFCSRSMAIPLNYRTMLIPPLLADANERERGSLQADPVVGTFKTYLTTTGSLVVSLTFSYCKNLATVEDVLTGDSSSPSSSVLAAPYGVFATKQNFANGDGSDRSLAQTPNTQALSVRSVPDTNDSQWKHSCLKALEYCGLSPSQFKASPWVNLLISKPTSQDADGESKRSRATVPWPGSLCFRKKPMEMSTTHRVGDTMLSGHEECHDPLGDARGWFAGASEREERISKRKAERMYAVTREVNGANPLAQNLNGQSPLTMRRPSTAAAGVMYPTPPDAIQQHIGITPSIDGAISSPNNPPPTLAVVDADMTMPTATPMADAENDAWGGQHEQKRERSDSNAMGDSDDVMNDLGEDVFGDHDVTEDDFNFFDGPDGNDLDMDMPDLQPAPTTPAPQVMPPPVLSHPEPHKAIQPQPEVKPKPKTNDSVFAKPELKHARSSLNDELNRRIKVERPDTTKRGSSPFDPATVFKRVRASLSSPTKDDFAVQPPRRKSSVFEKVEFDPKIPLINKKYEHGGAFDFSKDQSNGDSRPSAHNLSRDEYLEGQGKLKQTSKSLLGNSLIRSLTGIDASTTHASPQRLNGHDWISEESDLESDGDDISSVSGGPVSPVKSSIKRTVVDDDALSQATTSRETELLDDVTDEQLAIELPKLSKTESPEMLLHRFFLDPEPLNVDVGLSNHDFVEIAQIITEQAATGRLEIGIEHKAESSVSLATMRSHELSIARNSLQLLHDAIPSNLGTPTAVRLKGLLEIQDLPLVGQPSRLQPRPIPGRDPNVEQLRANNLYQIPVPHLEVRRSETKLSVLPSSMSFWEGLGLSPSWGTKDISALCIFPGWKGMSDHVESFLSRLKSVYESLKLGTLNNLPLSGDWDDGVLPYEVDRISTSPDATVTGHGSALVESMEVLRSSLSELKSKDKNLVIYFVYSPDNPASIIEACTAFYRCFDEYSDLLAARRESPQNELVLQLVSLDMISSTTSLVVPTPAEMIKLCIETYDRCTLFLDTEFGGPTPAPAVMLEQPPPRMIDFKLTTSPSQSLMHENSCLHVGYAESLDGRWITAAWTDNRGQRQATTSYSITRSRTPDRSVSHHKAAIIAEIWATTLTMISIWKVHWRVIITKSGAMDQKEVEWWQAASTLDDKHSFTMILMSVDTNPSLQLVPPIVKIPHAATSAFYSTPVSTPQANIVSPEQTTTPATPMRDASTLAATPTAEGAAEAEADSFLIDATDQTWGAIVGHRLCNSTTLLEVRPALASGYLIKRTGIKLEDPPVVMEVNLVHTEATPRAYEPLLREMLCYFRGLGTLARARGVVDREMDVRPWHIAAAEKGVRALHLLL
Length1515
PositionKinase
OrganismFusarium oxysporum f. sp. radicis-cucumerinum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex.
Aromaticity0.06
Grand average of hydropathy-0.381
Instability index48.19
Isoelectric point5.19
Molecular weight165364.03
Publications
PubMed=27387256
PubMed=28831051

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16530
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     397.38|      87|     245|     514|     601|       1
---------------------------------------------------------------------------
  514-  600 (145.33/74.45)	..............GQHEQKRERSDSNAmGDSDDVMND.LGEDVF..G.....DH.DVTEDDFNFFDGPDGNDLDM..DMPDLQPAPTTPA.PQVMPPPVLSHPEPHKAIQPQ
  601-  690 (91.17/41.71)	PevkpkpktndsvfAKPELKHARSS..........LNDeLNRRIK..V.....ERpDTTKRGSSPFD.P.ATVFKR..VRASLS.SPTKDD.FAVQPPRRKSSVFEKVEFDPK
  692-  765 (66.25/28.29)	P....linkkyehgGAFDFSKDQSN....GDSRPSAHN.LSRDEYleG.....QG.KLKQTSKSLL....GNSLIR..SLTGIDASTTHAS.PQRL.................
  767-  854 (94.63/43.57)	..............G.HDWISEESDLES..DGDDISSV.SGGPVS..PvkssiKR.TVVDDD.ALSQATTSRETELldDVTDEQLAIELPKlSKTESPEMLLH...RFFLDPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     298.49|     103|     615|     318|     494|       2
---------------------------------------------------------------------------
  363-  486 (149.60/183.69)	PGSLCFrKKPMEMSTTHRVGDtmLSGheECHDPlgdarGWfAGASEREERISKRkAERMYAVTREVNGAN.PLAQNL.NGQSPLTMRRPSTAaagvmyptpPDA.IQQH.IGITPSID...GAIS...............SPNNPP
  990- 1114 (148.90/65.38)	PSSMSF.WEGLGLSPSWGTKD..ISA..LCIFP.....GW.KGMSDHVESFLSR.LKSVYESLKLGTLNNlPLSGDWdDGVLPYEVDRISTS.........PDAtVTGHgSALVESMEvlrSSLSelkskdknlviyfvySPDNPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.65|      54|    1174|      25|      78|       3
---------------------------------------------------------------------------
   25-   78 (93.29/53.09)	EPPPDQSHGFQSSALEIQSSLRDQGKL.VSYDADRVGIWIFQIVSKD.GTSKAVNS
 1200- 1255 (89.36/50.56)	EQPPPRMIDFKLTTSPSQSLMHENSCLhVGYAESLDGRWITAAWTDNrGQRQATTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.84|      20|     931|     488|     513|       5
---------------------------------------------------------------------------
  488-  513 (34.43/28.76)	TLAVVdadmtmPTATPMADAENDA.........WG
 1384- 1412 (28.41/12.53)	TLAAT......PTAEGAAEAEADSflidatdqtWG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16530 with Med13 domain of Kingdom Fungi
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