<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16498

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMDHGSRNGSHTNHDRDQRQNGANGVSRAAEKMQDKGKPRAEPLQSMTPTSPIIPEGLNRNTTGPPRHENGANGTLRNLQTQMGQLPPEITHIADGYMPLSALLIRLAQKSHADLLGAMGDLAQMPTPAATINGSASHYSLTEDASQENVRKKLRLLNFATTTHESWTKALVITGWSRKSEEVSKLVDLRIHLEAQKLLYTEAIDSMANNKRAIHNFRLPNPDFRTALEVLTTGTASWMPDLNYIQPRPLTAKEVLRSLEKLNTLLSIRLNLDDYDSIPLQFRDFTIQSGRATFRVPGEFEIDLTIADEEPGSQYWFIDLRFLFRPSSSKMTAGIRWHLENKVNEVLLKDGLKGCYKYLHELILTYKIAEFRRQGDELARSIWIDTLKVEILNRPICIQYWIDRYSGRLLDGRPSNVKPSKSWIILGVHSGRRNDGRPDANATSRLFIRWFRESKEVMDEDIWFDDVKISTESLLKTVIAKHISHILTSMYEKLLAKPLYAKRELEISLKPSSDDPADLEINIQLTNEHRLSIKIDPVSGRFVFGPISRIYSHYEGLLNSVCQDPAADGHTAIERLRSALLTDAIQIHASSLSWYRVNNPGLTQDSLNQFVPKESLATIWFRRPGWVKDWYLAVTQSMSGEKWHLIKTAIKPTPVKSNAIGLGCLLELPIKGASPSTTYSFLSTLNIFAAGMLSHYTTARTLHSRRVHYVLGKGKLARSMTLPAIYAKLSELIPSKNRLPRTGRNWARDVIKIYFHGVEVIAQRSKDQAELGPSQSTLVSQVSAPNLQSSSALDSQKAFELDERSVLVIEVRMVMPIPQALSSINEQLDKNIVFDAKTGSLAFRLQSKVGESFVPELIERIVGVERLVEFVQVLHLHEVTLKCETVSLGKLVFTYPNNHFVANPDVMDTENISPTYKATINFSVADNIMALVLESGNPHLRIADHLTKVLNGPEGLGGIATLLPLTLPVLRGLDAVETAWYSDGIFDKGEVVVNVRATDVYRLRYEIHLKSPLTADTSTITRKVGFEIKLRSRKAEAWWYVQRVGSSRQKGLDALDDALKSVWDMSGPDWRGMRVCAVAKSNGIEMLLVKLDEVMRNFVLSGKGLDSPLAAPPGSAPAPPKQALNPRMQQQQRQQQRHQQPPTNHNQSQGRNNTHNNQSREIVEID
Length1170
PositionTail
OrganismDiplocarpon rosae
KingdomFungi
Lineage
Aromaticity0.07
Grand average of hydropathy-0.347
Instability index45.40
Isoelectric point9.12
Molecular weight131347.64
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats
>MDP16498
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.34|      17|      21|     398|     418|       1
---------------------------------------------------------------------------
  402-  418 (35.43/28.26)	IQY...WI..DRYSGRLLDGRP
  421-  442 (25.91/ 8.75)	VKPsksWIilGVHSGRRNDGRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     289.80|      67|     144|     188|     254|       2
---------------------------------------------------------------------------
  188-  254 (111.76/81.84)	SKL.VDLRIHLE..AQKLLYTEAIDSMANNKRAIHNFRLPN..PDFRTALEVL..TTGTASWMPDLNY.IQPRPL
  267-  331 (96.98/69.89)	NTL.LSIRLNLD..DYDSIPLQFRDFTIQSGRA..TFRVPG...EFEIDLTIAdeEPGSQYWFIDLRF.L.FRPS
  333-  400 (81.05/57.01)	SKMtAGIRWHLEnkVNEVLLK...DGLKGCYKYLHELILTYkiAEFRRQGDEL..ARSI..WIDTLKVeILNRPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.41|      18|      21|      69|      89|       3
---------------------------------------------------------------------------
   23-   40 (29.86/11.44)	RQNGANGVSRAAEKMQDK
   72-   89 (31.55/21.89)	HENGANGTLRNLQTQMGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.78|      11|      21|     650|     661|       4
---------------------------------------------------------------------------
  650-  661 (15.12/12.80)	IKTAiKPTPVKS
  674-  684 (18.65/10.31)	IKGA.SPSTTYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.92|      16|     298|     520|     554|       5
---------------------------------------------------------------------------
  503-  518 (25.94/19.89)	LYAKRELEISLKPSSD
  529-  544 (26.98/20.79)	LTNEHRLSIKIDPVSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.76|       9|      23|     599|     609|       6
---------------------------------------------------------------------------
  599-  609 (13.32/13.02)	YRvnNPGLTQD
  625-  633 (19.44/10.97)	FR..RPGWVKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.76|      12|      61|     487|     499|       9
---------------------------------------------------------------------------
  487-  499 (18.24/18.71)	ISHILtSMYEKLL
  551-  562 (23.52/17.81)	ISRIY.SHYEGLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16498 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GKGLDSPLAAPPGSAPAPPKQALNPRMQQQQRQQQRHQQPPTNHNQSQGRNNTHNNQSREIVEID
2) MPGVIMDHGSRNGSHTNHDRDQRQNGANGVSRAAEKMQDKGKPRAEPLQSMTPTSPIIPEGLNRNTTGPPRHENGANGTLRNLQTQMGQLPPEITH
1106
1
1170
96










Molecular Recognition Features






MoRF SequenceStartStop




NANANA