<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16497

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMETPSWKALKLSLERPYKDENGVPIPVLQDITPQGEQIYEPKQTTSQVLGENLRRIFLERGVDFFEKTKDGNLADRIAEAHVDVKDTSLATTESDDDEDGPSIMTSEELFKMRSEITSQLFIALGEMTHARDLLSAILSTSGQAPHSIPGIPVPEIQHQAAPLAATIVRKPPPILSVQAFNTQLAIGSKDEALRKASDVFKAAADRLEGGRLRGEKYWADALKIRRGNWALIPAPLPLGSATGKGADKSSKDFLISYGLEESSSSFRRRAIGHMASLENASEELIFPFRQRTSLRVSLTSGEGHTSLAFSKNDSRTEDSALDNLLKNSQREIVEQEIFSLLVHEASRLPTASAKVSERLIVIDSALGTELKFELVESDSVTPLASRNALQQATCDLIYHSLHALLLRRHQHLKSQRLSGSDAPKIDPPPVLQPIIDLLQYQVFCQRVKTVIEGIVTALTLAGIASTLWFQPVGEVGHELVNLLDNRHAKTVGGQCILRIDRRHTVRFSFLAPSTLNAHLAQATLTISSIPQLNQLLTDDVGRFLLQRICELGREISGDVSGIWFLDLNRCVGRWEGCTLNFQIDFHANSTLRCTLFRLDRHTSKQGESEIYHSGRTDPLIPWVEGKIRKALGVP
Length634
PositionHead
OrganismArmillaria gallica (Bulbous honey fungus) (Armillaria bulbosa)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Physalacriaceae> Armillaria.
Aromaticity0.06
Grand average of hydropathy-0.245
Instability index39.89
Isoelectric point6.25
Molecular weight70191.04
Publications
PubMed=29085064

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16497
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.13|      13|      14|     475|     487|       1
---------------------------------------------------------------------------
  475-  487 (23.37/15.10)	VGHELVNLLDNRH
  491-  503 (24.77/16.42)	VGGQCILRIDRRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.37|      21|     401|       7|      31|       2
---------------------------------------------------------------------------
    7-   31 (32.79/27.49)	KALKLS.LERPYKDengvPIPVLQDI
  413-  434 (35.58/19.94)	KSQRLSgSDAPKID....PPPVLQPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.60|      11|      19|     259|     269|       3
---------------------------------------------------------------------------
  259-  269 (19.51/ 9.93)	LEESSS....SFRRR
  277-  291 (15.09/ 6.29)	LENASEelifPFRQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.70|      15|      16|     526|     540|      10
---------------------------------------------------------------------------
  526-  540 (24.31/14.13)	ISSIPQLNQLLTDDV
  545-  559 (25.39/15.06)	LQRICELGREISGDV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16497 with Med17 domain of Kingdom Fungi
Unable to open file!