<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16487

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSLNVATTNEEISNVAYLVASSSSPATIDAFRRRIAARHTGSSLLDSLLSSVHVAATSYIYLFRIIRGIQLDSFNDLDLNGLNVVESSSFSPQDIVFPTFPAKALRTVISHFLNSVRIRLLDDISHDASVLGRLNSGFLIAHSTTSNEWSAPWAIMRPLVYCHLQVHLTSSRLLIHPLVIPTSFLPVTPSLTQGSPILLLPYATPAYFLTSYKGPCSALSKQFKECFEGLGVSSWDPESYIIAWVSVENRQGEDKGVMIIYPTSLCVRSLFPNIPSLPHIPTLPATLQSSPDSTPSLPFLSVSSPTSVSAFRTLTISKSRDINRVAKEVGGYVDAVAKERERERERLKREREGVGTTVVQPSSAQVPHLYVQQQVQLQQQQQTQQQMQQQQQQAQQQQQMLDFYPSPPQTNLMVPPPSGHVSPVAPVAAPMEVDPLPNPAPSQPSYEPFNSNWMDMEDWMNGLGDTVNVGNGGDRGMGIGMMDFEADFTEDDFSFFDDKPPPPMPAVTGLTPAAPLEDPHWEIEPTPDVGTGLPSPPAESVLNFRVDDIKVQMKVDTAGGLWDAIPFADSYRATDGKYNMGKFSSSPGRAEGWRKRYEKVTDPRLGVVKRLALRRAKSIDEPERDDWEAEWREGNPEPEEDSDGADDSDEDMESAGEEESVDDAEGERPCTPLPAWIPMGPALLPMHFRHEVMLPLSAPLRSGVVGGSSGVGAGVSSVPTPVSPGRVGKGKSLQVAAESLGKEIVENSVWAAVWDGVNAKGNPGGFGRTLWEKDVQVVGRLFSAVQDINAPVQLEKLFGLTGSSGTGNGAESRLEKLESPMLLVGKGDAVIQILPPALRFWDKLGLGPRSGKKDIQAFVVFDSLQEQMPDKISEWLVNLRTVYEGKHFGTVSFGQSQFCEQDMNGVVPIRYDSTLRKTLDAFITGSSSPPRTSTVVFIVTSITTMTLLSPILRQLFSVVRKASASHPQMLFHFVPEQIFYSESNSQVEDLCGSVYDRILVPVVRSMSRKLSSAGEVTKFLEDPSFVLARTPEEAKVVYSGPKADATAMILGVMDKGTFLHVGYGVSECGKWIFASCNDQRGDGHDLGVWLTSKGGGEANEGEVDEMTFLVHKVWDFTARFAKKANIEWRIVIAKLGSMGEAELDAWTRHLENDTEMGPVHVSVVAVEPSTPWMFTSRPEFDAPKFVPPSLKSIGRSASVSSSKPSKHNTHPVFVDIAFSTYALFQQSPLPVSVPPTLSDMGLDLGHIPDPSPWHGGEETHPQSPSIEHDHNNLPHVLPLIPHASSTLIRVPSSTTVATTTMLHIHLLHMIRSVGCSYPASDYNQLLRDITHSYYALSVLSSLKWPMKGANPILPSHLGAVEAMRTAVVSGGSTDTPDS
Length1378
PositionKinase
OrganismArmillaria gallica (Bulbous honey fungus) (Armillaria bulbosa)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Physalacriaceae> Armillaria.
Aromaticity0.08
Grand average of hydropathy-0.226
Instability index51.25
Isoelectric point5.32
Molecular weight150535.59
Publications
PubMed=29085064

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP16487
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     716.53|     166|     177|     423|     595|       1
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  354-  415 (51.05/17.22)	.................................................................................................................................VGTTVVQPSSA.....Q.VPHLY.VQQQVQLQQ......QQQ...T...QQQ..MQQQQQQAQQQQQMLDFYPSPPQTNLMVP
  423-  595 (286.96/153.35)	PVAPVAAPMEVDPLPNPAPSQPSYEpfnsnwmDME.DWMN.GLGDTVNVGNGGDRGMG........IGMMDFEADFTEDDFSFFDDKPPPPMPAVTGLTPA...........APLEDP..HWEIEPTPDVGTGLPSPPAESVLNFR.VDDIK.VQMKVDTAG......GLW...D...AIP..FADSYRATDGKYNMGKFSSSPGRAEGWRK
  603-  773 (216.10/104.43)	PRLGVVKRLALR..RAKSIDEPERD.......DWEaEWRE.GNPEPEEDSDGADDS.D........EDMESAGEEESVDDAE..GERPCTPLPAWIPMGPAllpmhfrhevmLPLSAPlrSGVVGGSSGVGAGVSSVPT.PVSPGR.VGKGKsLQVAAESLGkeivenSVW...A...AV.......WDGVNAKGNPGGF....GRTL.WEK
  784-  931 (162.41/76.53)	AVQDINAPVQLEKL..........................fGLTGSSGTGNGAESRLEklespmllVGKGDAVIQILPPALRFWDK.........LGLGPR...........SGKKDI..QAFV.VFDSLQEQMPDKISEWLVNLRtVYEGK.HFGTVSFGQ......SQFceqDmngVVPirYDSTLRKTLDAFITG..SSSPPR......
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.97|      49|     823|     165|     257|       2
---------------------------------------------------------------------------
  182-  236 (86.96/90.26)	TSFLPVTPSLTQ..GSPILLL..PYATPAYFLTSYKGPCSAlskqfkECFEGLGVS.SWD
  268-  321 (73.01/20.81)	RSLFPNIPSLPHipTLPATLQssPDSTPSLPFLSVSSPTSV......SAFRTLTISkSRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.36|      48|      49|    1164|    1211|       3
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 1114- 1161 (46.17/22.47)	........WDFTARFAKKANiewRIVIAKLGSMGEA.ELDAWTRH..LENDTemgpvHV
 1164- 1211 (85.49/48.36)	VAVEPSTPWMFTSRPEFDAP...KFVPPSLKSIGRS.ASVSSSKP..SKHNT.....HP
 1214- 1261 (69.70/37.97)	VDIAFSTYALFQQSP...LP...VSVPPTLSDMGLDlGHIPDPSPwhGGEET.....HP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.44|      28|      49|     947|     979|       4
---------------------------------------------------------------------------
  947-  979 (38.62/34.71)	LLSPILRqlfSVVRKASASHPqmLFHFVPEQIF
  998- 1025 (46.83/26.42)	ILVPVVR...SMSRKLSSAGE..VTKFLEDPSF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16487 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EDDFSFFDDKPPPPMPAVTGLTPAAPLEDPHWEIEPTPDVGTGLPSPPAESVL
2) LYVQQQVQLQQQQQTQQQMQQQQQQAQQQQQMLDFYPSPPQTNLMVPPPSGHVSPVAPVAAPMEVDPLPNPAPSQPSYEPFNSNWMDMEDWMNGLGDTVNVGNGGDRGMGIGMMD
3) SIDEPERDDWEAEWREGNPEPEEDSDGADDSDEDMESAGEEESVDDAEGERPCTPLPAW
4) VDAVAKERERERERLKREREGVGTTVVQPSS
490
369
618
333
542
483
676
363










Molecular Recognition Features






MoRF SequenceStartStop




1) EADFT
485
489