<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16483

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMDINDLHPPDDYSHRFFIWHEWIQANGPLTSENVFEYFATSMFYDKQSNNQVLRMQTMHTDVAVMNEAEELKRFTGVEFAVVDAQPPSFFIIQKRERLSPEEVIPLSAYFIINNRIYQSPDLYTVLSNRLLTSLTSLQTSLDILRSHRPDYTPRTGFVWPITDPSLDETAKKPAADDLTGANTPMPDDNTSPADGNGKRQQNTMLLFNAMRATALHSSSAVSSSAFAQMTSSTVPPTEIQVHAQAQVQTPTAGTQASTVPSQASTPAPPPQEPPGRGPPGGGKKKRKRTLLPAPGS
Length296
PositionHead
OrganismArmillaria gallica (Bulbous honey fungus) (Armillaria bulbosa)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Physalacriaceae> Armillaria.
Aromaticity0.08
Grand average of hydropathy-0.527
Instability index49.44
Isoelectric point5.80
Molecular weight32670.22
Publications
PubMed=29085064

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364143
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP16483
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.89|      21|      23|     248|     268|       1
---------------------------------------------------------------------------
  248-  268 (38.16/20.06)	QTPTAGTQASTVPSQAST..PAP
  272-  294 (32.74/16.19)	EPPGRGPPGGGKKKRKRTllPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.32|      18|      18|      90|     107|       2
---------------------------------------------------------------------------
   90-  107 (31.57/21.79)	FIIQKRERLSPEEVIPLS
  110-  127 (32.75/22.85)	FIINNRIYQSPDLYTVLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.24|      18|     137|       1|      19|       3
---------------------------------------------------------------------------
    1-   19 (35.28/25.24)	MDINDLHPPdDYSHRF.FIW
  141-  159 (32.95/18.60)	LDILRSHRP.DYTPRTgFVW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.81|      10|      17|     164|     174|       4
---------------------------------------------------------------------------
  164-  174 (13.48/10.35)	PSLDETAKkPA
  184-  193 (20.33/11.12)	PMPDDNTS.PA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16483 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ETAKKPAADDLTGANTPMPDDNTSPADGNGKRQQNTMLLFNAMR
2) SSSAVSSSAFAQMTSSTVPPTEIQVHAQAQVQTPTAGTQASTVPSQASTPAPPPQEPPGRGPPGGGKKKRKRTLLPAPGS
168
217
211
296










Molecular Recognition Features






MoRF SequenceStartStop




1) EPPGRGPPGGGKKKRKRTLLPAPGS
272
296