Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MADASSMSSILLAPLTDLQILSQALFVSLSPVTKPPPPPPPPVSAFLSCDQALASAVNTAHSHQIRQRKIEALKNEILELDARWREICMELEREKRELEAMIEEGEERVQAIENAKKGSIPYPELLAYAQSLSAFTSAPPNMPDLQAGQPPPPLFFPPFPNEEKMRRGRLNAEAPLGLPGETHSIGAPTVSPKGPDANQMGPGANPYRQDLRAPQPQFFDLDLDLNPDL |
Length | 229 |
Position | Middle |
Organism | Armillaria gallica (Bulbous honey fungus) (Armillaria bulbosa) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Physalacriaceae> Armillaria. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.420 |
Instability index | 72.02 |
Isoelectric point | 4.83 |
Molecular weight | 25042.25 |
Publications | PubMed=29085064 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP16480 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 84.42| 23| 108| 14| 47| 1 --------------------------------------------------------------------------- 14- 40 (41.36/20.12) PLTDLQILSQalfvSLSPVTKPPPPPP 121- 143 (43.06/10.87) PYPELLAYAQ....SLSAFTSAPPNMP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) QPQFFDLDLDLNPDL 2) YRQDLRA | 215 207 | 229 213 |
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