<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16479
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MSLAELTRNCFQSGISASKWLGLCRLLIAKDNGLQESDAVESTLSNSVLSMLRFYPGNPDLQEYLKYAIQDGMISVAVFVATMLQAARSPELHHPATLDMLCRIALDSHYSSGSPPMGSVVSYGESAIIIVGTVQDALALLRTAHALPLTHFHQLTTSASELVILLLSCVSDLSQVSTAQASIQLQDITEILQSFRLTPAVRQALDTYMVSLGFLTGDDAKAAREAQMMHSLQVALGKDDVSGPNSDVDVITFGLELHHLVTHRAKHFGAGCGPDAAALLVGTFRRSSWPAPVFYTQLFTAALLCLSQAPQSTCFIWRAFIVGRLPALLTIFETAMTSDNTVDADWRSAMQAAMSIFHRPDMMVHCDHVLASAEGTEAFYPNLPFSRELLRQLVDTGLLDDRNALGVDPTVLEKSLLPLHAEAQNAGFDIHSYIDCKLHPDLTTEEAHTLFDRICKEAATHSAFASVVMKRFISLSTSFDVEALSRLCKALYLRHRILDIISLHVKIDELLYQTVSLVDSYDCETIGDPQTAVSHLGDIVMFSQYTLAHFNLDAKMFIQGDRTVSGVFLQSASQVFSHESLSGEDAQAFNAWFKTLFDSGSEGIEDTILRSSRPKTLLKIASTLFSSAINARIEGKIDGDTLNNGISFFTGPLLSWTLVGVVRSLLQEIYRKGFMAPVHIEVLQTLLLSPSCPKPVLVLCGSRILTLLASKPAKDRLAAVRFDVVTVQRLVSEALGPRETACRSAEIAWPAHIQHAMSLGMHVPWQEQSKRAIQNVLAAARAGKAPSIDVDRLVKTTTPSKFLRSLWTELSLSAGLAETETFRRFITFVLTTPLSSAGPPLLPIFLHTVLPSILVSVDASQPQSHANIELLVITVSSVLTAALHLELALRGTRWEHRLVFGHPIASMARRLATDLRNANSYAGTAIIQRLGSSQSFVANFPVFMGELGV |
Length | 949 |
Position | Tail |
Organism | Armillaria gallica (Bulbous honey fungus) (Armillaria bulbosa) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes>
Agaricomycetidae> Agaricales> Physalacriaceae> Armillaria.
|
Aromaticity | 0.07 |
Grand average of hydropathy | 0.204 |
Instability index | 48.15 |
Isoelectric point | 6.07 |
Molecular weight | 103629.07 |
Publications | PubMed=29085064
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP16479
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 157.55| 51| 83| 602| 652| 1
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602- 652 (84.62/54.90) EGIEDTILRSSRPKTLL.....KIASTLFSSAINARIEG.KIDGDTLNNGISFFTGP
681- 737 (72.94/46.31) EVLQTLLLSPSCPKPVLvlcgsRILTLLASKPAKDRLAAvRFDVVTVQRLVSEALGP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 75.69| 22| 28| 833| 854| 2
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833- 854 (39.84/27.24) PLSSAGPPLLPIFLHTVLPSIL
862- 883 (35.85/23.70) PQSHANIELLVITVSSVLTAAL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 139.47| 45| 84| 404| 452| 3
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404- 452 (66.42/68.79) ALGVDPTVLEksLLPLHAEAQNAGFD....IHSYiDCKLHPDLTTEEAHtLFD
490- 538 (73.05/56.70) ALYLRHRILD..IISLHVKIDELLYQtvslVDSY.DCETIGDPQTAVSH.LGD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 41.03| 12| 28| 317| 332| 5
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317- 332 (17.63/19.63) WRafivGRLPALLTIF
346- 357 (23.40/13.56) WR....SAMQAAMSIF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 62.70| 21| 33| 125| 146| 8
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125- 146 (29.19/22.45) ESAIIIVGTVQDaLALLRTAHA
161- 181 (33.51/21.10) ELVILLLSCVSD.LSQVSTAQA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.83| 14| 31| 542| 557| 9
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542- 557 (20.66/21.79) FSQYTLAhfNLDAKMF
576- 589 (25.16/16.75) FSHESLS..GEDAQAF
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