<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16479

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMSLAELTRNCFQSGISASKWLGLCRLLIAKDNGLQESDAVESTLSNSVLSMLRFYPGNPDLQEYLKYAIQDGMISVAVFVATMLQAARSPELHHPATLDMLCRIALDSHYSSGSPPMGSVVSYGESAIIIVGTVQDALALLRTAHALPLTHFHQLTTSASELVILLLSCVSDLSQVSTAQASIQLQDITEILQSFRLTPAVRQALDTYMVSLGFLTGDDAKAAREAQMMHSLQVALGKDDVSGPNSDVDVITFGLELHHLVTHRAKHFGAGCGPDAAALLVGTFRRSSWPAPVFYTQLFTAALLCLSQAPQSTCFIWRAFIVGRLPALLTIFETAMTSDNTVDADWRSAMQAAMSIFHRPDMMVHCDHVLASAEGTEAFYPNLPFSRELLRQLVDTGLLDDRNALGVDPTVLEKSLLPLHAEAQNAGFDIHSYIDCKLHPDLTTEEAHTLFDRICKEAATHSAFASVVMKRFISLSTSFDVEALSRLCKALYLRHRILDIISLHVKIDELLYQTVSLVDSYDCETIGDPQTAVSHLGDIVMFSQYTLAHFNLDAKMFIQGDRTVSGVFLQSASQVFSHESLSGEDAQAFNAWFKTLFDSGSEGIEDTILRSSRPKTLLKIASTLFSSAINARIEGKIDGDTLNNGISFFTGPLLSWTLVGVVRSLLQEIYRKGFMAPVHIEVLQTLLLSPSCPKPVLVLCGSRILTLLASKPAKDRLAAVRFDVVTVQRLVSEALGPRETACRSAEIAWPAHIQHAMSLGMHVPWQEQSKRAIQNVLAAARAGKAPSIDVDRLVKTTTPSKFLRSLWTELSLSAGLAETETFRRFITFVLTTPLSSAGPPLLPIFLHTVLPSILVSVDASQPQSHANIELLVITVSSVLTAALHLELALRGTRWEHRLVFGHPIASMARRLATDLRNANSYAGTAIIQRLGSSQSFVANFPVFMGELGV
Length949
PositionTail
OrganismArmillaria gallica (Bulbous honey fungus) (Armillaria bulbosa)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Physalacriaceae> Armillaria.
Aromaticity0.07
Grand average of hydropathy0.204
Instability index48.15
Isoelectric point6.07
Molecular weight103629.07
Publications
PubMed=29085064

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16479
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.55|      51|      83|     602|     652|       1
---------------------------------------------------------------------------
  602-  652 (84.62/54.90)	EGIEDTILRSSRPKTLL.....KIASTLFSSAINARIEG.KIDGDTLNNGISFFTGP
  681-  737 (72.94/46.31)	EVLQTLLLSPSCPKPVLvlcgsRILTLLASKPAKDRLAAvRFDVVTVQRLVSEALGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.69|      22|      28|     833|     854|       2
---------------------------------------------------------------------------
  833-  854 (39.84/27.24)	PLSSAGPPLLPIFLHTVLPSIL
  862-  883 (35.85/23.70)	PQSHANIELLVITVSSVLTAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.47|      45|      84|     404|     452|       3
---------------------------------------------------------------------------
  404-  452 (66.42/68.79)	ALGVDPTVLEksLLPLHAEAQNAGFD....IHSYiDCKLHPDLTTEEAHtLFD
  490-  538 (73.05/56.70)	ALYLRHRILD..IISLHVKIDELLYQtvslVDSY.DCETIGDPQTAVSH.LGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.03|      12|      28|     317|     332|       5
---------------------------------------------------------------------------
  317-  332 (17.63/19.63)	WRafivGRLPALLTIF
  346-  357 (23.40/13.56)	WR....SAMQAAMSIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.70|      21|      33|     125|     146|       8
---------------------------------------------------------------------------
  125-  146 (29.19/22.45)	ESAIIIVGTVQDaLALLRTAHA
  161-  181 (33.51/21.10)	ELVILLLSCVSD.LSQVSTAQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.83|      14|      31|     542|     557|       9
---------------------------------------------------------------------------
  542-  557 (20.66/21.79)	FSQYTLAhfNLDAKMF
  576-  589 (25.16/16.75)	FSHESLS..GEDAQAF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16479 with Med5 domain of Kingdom Fungi
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