<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16469

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSLNVATTNEEISNVAYLVASSPSPATIDAFRRRIAVRHTGSSLLDSLLSSVHVAATSYIYLFRIIRGIQLDSFNDLDFNGLNVVESSSFSPQDIVFPTFPVKALRTVISHFLNAVRIRLLDDISHDASVLGRLNSGFLIAHSTASNEWSAPWAIMRPLVYCHLQVHLTSSRLLIHPLVIPTSFLPVTPSLTQGSPILLLPYATPAYFLASYKGPCSALSKQFKECFEGLGVSSWDPESYIIAWVSVENRQGEDKGVMIIYPTSLCVRSLFPNIPSLPHIPTLPATLQSSPQSTPSLPFLSVSSPTSVSAFRTLTISKSRDINRVAKEVGGYVDAVAKERERERERLKREREGVGTTVAQPSSAQVPHLYVQQQVQLQQQQQTQQQQMQQQQAQQQQQMLDFYPSPPQTNLMVPPPSGHVSPVAPVAAPMDVDPLPNPAPSQPSYESFNSNWMDMEDWMNGLGDTVNVGNSGDRGMGIGMMDFEADFTEDDFSFFDDKPPPMPAVTGLTPAAPLEDPHWEIEPTPDVGTGLPSPPAESVLNFRVDDIKVQMKVDTAGGLWDAIPFADSYRATDGKYNMGKFSSSPGRAEGWRKRYEKVTDPRLGVVKRLALRRAKSIDEPERDDWEAEWREGNPEPEEDSDGADDSDEDMESAGEEESVDDTEGERPCTPLPAWIPMGPALLPMHFRHEVMLPLSAPLRSGVVGGSSGVGAGVSSVPTPVSPGRVGKGKSLQVAAESLGKEIVENSVWAAVWDGVNSKGNPGGFGRTLWEKDVQVVGRLFSAVQDINAPVQLEKLFGLAGSSGTGNGTESRLEKLESPMLLVGKGDAVIQISSPALRFWDKLGLGPRSGKKDIQAFVVFDSLQEQMSDKISEWLVNLRTVYEGKHFGTVSFGQSQFCEQDMNGVVPIRYDSTLRKTLDAFIAGSSSPPRTSTIVFIVTSITTMTLLSPILRQLFSVVRKASASHPQMLFHFVPEQILYSESNSQVEDLCGSVYDRILVPVVRSMSRKLSSAGEVTKFLEDPAFVLARTPEESKVVYSGPKADATAMILGVMDKGTFLHVGYGVSECGKWIFASCNDQRGDGHDLGVWLTSKGGGEANEGEVDEMTFLVHKVWDFTARFAKKANIEWRIVIAKLGSMGEAELDAWTRHLENDTEMGPVHVSVVAVEPSTPWMFTSRPEFDAPKSVSPSLKSIGRSASVSSSKPSKHNSHPVFVDMAFSTYALFQQSPLPVSVPPTLSDMGLDLGHIPDPSPWHGGEETHPQSPSIEHDHSNLPHVLPLIPHASSTLIRVPSSTTVATTTMLHIHLLHMIRSVGCSYPASDYNQLLRDITHSYYALSVLSSLKWRMKGVNPILPSHLGAVEAVRTAVVSGGSTDTPDS
Length1376
PositionKinase
OrganismArmillaria solidipes
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Physalacriaceae> Armillaria.
Aromaticity0.08
Grand average of hydropathy-0.220
Instability index51.95
Isoelectric point5.36
Molecular weight150237.17
Publications
PubMed=29085064

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16469
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     149.51|      42|     132|     995|    1043|       1
---------------------------------------------------------------------------
  514-  535 (25.68/ 7.71)	............................LED.....PHW..EIEPTPDVGTGLPSPP....
  995- 1043 (64.88/50.75)	RILVPvvrsmsrKLSSAGEV.....TKFLED.....PAF..VLARTPEESKVVYSGPKADA
 1127- 1180 (58.95/33.12)	RIVIA.......KLGSMGEAeldawTRHLENdtemgPVHvsVVAVEPSTPWMFTSRPEFDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     206.94|      54|     130|     271|     355|       2
---------------------------------------------------------------------------
  186-  217 (43.93/ 8.55)	PVTPSLTQ...GSPILLL..PYATPAYFLASYKG....................PCS.......................
  272-  330 (85.85/76.23)	PNIPSLPH.IPTLPATLQssPQSTPSLPFLSVSS....................PTSVSAFRtltISKSRDINRVAKEVG
  667-  739 (77.15/25.51)	PCTP.LPAwIPMGPALL...PMHFRHEVMLPLSAplrsgvvggssgvgagvssvPTPVSPGR...VGKGKSLQVAAESLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.88|      44|     409|     348|     492|       3
---------------------------------------------------------------------------
  404-  451 (77.65/121.80)	PSPpqtnLMVPPPSGHVS.PVAPVAAPMDVDPLPNPAPSQPSYESFNSN
 1226- 1270 (81.23/ 8.99)	PLP....VSVPPTLSDMGlDLGHIPDPSPWHGGEETHPQSPSIEHDHSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.92|      36|     505|     558|     599|       4
---------------------------------------------------------------------------
  558-  599 (51.09/49.86)	GLWdaiPFA...DSyRAtDGkYNMGKFSSSPGRAEGWRKRYEKVT
 1067- 1105 (61.83/36.48)	GKW...IFAscnDQ.RG.DG.HDLGVWLTSKGGGEANEGEVDEMT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.06|      36|     349|     927|     965|       5
---------------------------------------------------------------------------
  927-  965 (56.87/46.76)	PPRTSTIVFIVTSIT..TMTLLSPilrQLFSVVRKASASHP
 1279- 1316 (61.19/41.93)	PHASSTLIRVPSSTTvaTTTMLHI...HLLHMIRSVGCSYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.64|      40|      43|     763|     803|       9
---------------------------------------------------------------------------
  763-  803 (65.32/42.32)	GFGRTL..WEKDVQVVGRlFSAVQDINAP.VQLEKLFGLAGSSG
  807-  849 (61.32/35.40)	GTESRLekLESPMLLVGK.GDAVIQISSPaLRFWDKLGLGPRSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.22|      14|     122|     621|     634|      10
---------------------------------------------------------------------------
  621-  634 (30.37/17.15)	ERDDWEAEW....REGNP
  744-  761 (22.85/11.14)	ENSVWAAVWdgvnSKGNP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16469 with Med13 domain of Kingdom Fungi
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