<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16464
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MSLAELTRNCFQSGISASKWLGLCRLLIAKDNGLQESDAVESTLSNSVLSMLRFYPGNPDLQEYLKYAIQDGMISVAVFVATMLQAARSPDLHHPATLDMLCRIALDSHYSSGSPPMGSVVSYGESAIIIVGTVQDALALLRTAHVLPLTHFHQLTTSASELVILLLSCVSDLSQVSTTQASFQLQDITEILQSFRLTPAVRQALDTYMVSLGFLTGDDAKVAREAQMMHSLQVALGKDDVSGPNSDADVITFGLELHHLVTHRAKHFGAGCGPDAAALLVGTFRRSSWPAPVFYTQLFTAALLCLSQAPQSTCFIWRAFIVGRLPALLTVFEAAMTSDNTVDADWRSAMQAAMSIFHRTDMMVHCDHVLVSAEGTEAFYPNLPFSRELLRQLVDTGLLDDRNALGVDPTVLEKSLLPLHAEAQNAGFDIHSYIDCKLLPDLTIEEAHTLFDRICKEAATHSAFASVVMKRFISLSTSFDVEALSRLCKALYLRHRILDIISLHVKIDELLYQTVSLVDSYDCETIGDPQTAVSHLGDIVMFSQYTLAHFNLDAKMFVQGDRTVSGLFLQSATQVFSHESLSGEDAQAFNAWFKTLFDSGSEGIEDTILRSSRPKTLLKIASTLFSSAINARIEGKIDGDTLNNGISFFTGPLLSWTLVGVVRSLLQEIYRKGFMAPVHIEVLQTLLLSPSCPKPVLVLCGSRILTLLASKPAKDRLAAVRFDVVTVQQLVSEALGPRETAHIQHAMSLGMHVPWQEQSKRAIQNVLAAARAGKAPSIDVDRLVKTTTPSKFLRSLWTELSLSAGLAETETFRRFITFVLTTPLSSAGPPLLPIFLHTVLPSILVSVDASQPQSHANIELLVITVSSVLTAALHLELALRGTRWEHRLVFGHPIASMARRLATDLRNANSYAGTAIIQRLGSSQSFVANFPVFMGELGV |
Length | 939 |
Position | Tail |
Organism | Armillaria solidipes |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes>
Agaricomycetidae> Agaricales> Physalacriaceae> Armillaria.
|
Aromaticity | 0.07 |
Grand average of hydropathy | 0.222 |
Instability index | 47.13 |
Isoelectric point | 6.01 |
Molecular weight | 102583.93 |
Publications | PubMed=29085064
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP16464
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 454.51| 153| 207| 368| 535| 1
---------------------------------------------------------------------------
368- 535 (225.16/157.64) HVLVSAEGTEAFypNLPFsRELL....RQLVDTGLLDDR.NALGVDPTVLEKSLLPLHAEAQ......NAGFdihSYIDCKLLPDLTIEEAHTLFDRICKEAATHSAFASVVMKRFISLSTSFDVEAlsrLCKAlylrhRILDIISLHVKIDEL...LYQTVSlVDSYDCETIGDPQTA.VSH
578- 745 (229.35/125.65) HESLSGEDAQAF..NAWF.KTLFdsgsEGIEDTILRSSRpKTLLKIASTLFSSAINARIEGKidgdtlNNGI...SFFTGPLLSWTLVGVVRSLLQEIYRKGFMAPVHIEVLQTLLLSPSCPKPVLV...LCGS.....RILTLLASKPAKDRLaavRFDVVT.VQQLVSEALGPRETAhIQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 75.69| 22| 28| 823| 844| 2
---------------------------------------------------------------------------
823- 844 (39.84/26.18) PLSSAGPPLLPIFLHTVLPSIL
852- 873 (35.85/22.78) PQSHANIELLVITVSSVLTAAL
---------------------------------------------------------------------------
|