<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16461

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMVVDISPPINNVMPASNGIHTNGSIELNIDEHERELPFVDDGQIPLGELLSRVMQSIYAELSELAETMPNMSDSARKRTMADWVVKTKKQVVKLYAVAKWARDAGTVQKCMNITAFLMNQNQQFADVLGSLEAIRDAMAPARLRNHDLLTSLDVLTTGSYRRLPTIIKKSIIPPHPLTDAEVLKTLTDMEDVMRYRLRLTEIIPVEMSHYRISNGRVYFTAPKLFETSICLRGAEKDDGWFFVHVEFLITVGGDATGIQEFPRIPTGIMKRHLADEADSRLAFYLPMPEQPPGVELPPRPVLPEGIVDTPLVRLYNFLQIMSLSYQLEILWYQAERMRSLGWAEFLSVNMTPDRKTMTVTYWRRKPMPNTGIHHRSIRIPEIGGKLVIAIVEARASVQAGGGPERSSKARVLADLQRKSKLGTKQPSDDVEGLRFKVTWEPEQGALGVQIPPEELILPSGMLAINADDLDFESLLLKVIQRHVNSIISMIQLNLQRGPSRAVFGAPGVVTLNEEDNSRGLRVRLCADEIVIITIDPRTGRLNLRDTGDLAAAGRGPRFFAVSEKINESPSMLMDALVRLRLQTIVDLAEQMAKYLGLQSFRTRNFPAEERRKLGPSARGTLFIQLEHFPDHYLVIVITDDNFQYALIESKVLRESMFANLVMEDIGWLDFDRIHGEDVARPDVEVRAGMKRKRSVDDGPNVPHMEADRKGFNLDTQVLRELYSYCCARVAYTKVERQFKLRSIQFTHVTPSTSANPLATELQSSLVRSVPSLCVQSKHILEGAPAAEAAMPNIRVIPLNWWSDSESGKGAQVVTCVKLKYVYVSKSGEGTSSIIRPSKRIIYDTTEAIVSFLSENVNTCVDEFLEEWARVSKMVVIAREVAQLKGRKGWEDVQLLDFDLQTAVFAYKGDYTVSITCEDQLNRPTGGKFELRFGRMGNVDGGRNPHSEAEPFLRTVLHAGKLGPSVHQLVMLLRDTLPIVVELSEFTDVDSFAKSAGWYRVLYRSHHALDFRLMTERRVAILDGSHSLFSLPSSTDDAQLGLKPIPNFAQIISELSGPGRRLDVGIVCRVNEVGGIAREVHDRVVKQLEGSRRYIFTGLTV
Length1100
PositionTail
OrganismArmillaria solidipes
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Physalacriaceae> Armillaria.
Aromaticity0.07
Grand average of hydropathy-0.182
Instability index40.23
Isoelectric point6.68
Molecular weight123443.61
Publications
PubMed=29085064

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16461
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     386.86|     137|     654|     231|     402|       5
---------------------------------------------------------------------------
  231-  402 (196.04/211.15)	LRGAEkddGWFFVH.VEF.....LITVGGDAT.GI...QEFPRiPTGiMK..............RHLADEADSRLAFYLPMPEQPPGVELPPRpVLPEGIvdTPLVRLYNFLQIMslSYQleilwyqaermRSLGWAEFL.SVNMTPDRKTMT.....................vtywrrKPMPNTGIHhrsirIPEIGG...KLVIAIVearASVQAGGG
  883- 1074 (190.82/123.27)	LKGRK...GWEDVQlLDFdlqtaVFAYKGDYTvSItceDQLNR.PTG.GKfelrfgrmgnvdggRNPHSEAEPFLRTVLHAGKLGPSVHQLVM.LLRDTL..PIVVELSEFTDVD..SFA...........KSAGWYRVLyRSHHALDFRLMTerrvaildgshslfslpsstddaqlglKPIPNFAQI.....ISELSGpgrRLDVGIV...CRVNEVGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.82|      22|      31|     131|     152|       7
---------------------------------------------------------------------------
  131-  152 (36.51/20.88)	LEAI..RDAMAPARLRNHDLLTSL
  163-  186 (30.05/15.97)	LPTIikKSIIPPHPLTDAEVLKTL
  189-  202 (18.26/ 6.98)	...M..EDVM.RYRLR....LTEI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16461 with Med14 domain of Kingdom Fungi
Unable to open file!