<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16440
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MFSFWVPTIECRRKSKKPSFHRKITPREQKNVTTRLNQLIETRLSRLSTGIPPNIKEIHIANGIATLLVPGEFEIKVTLLGETEMIKWQLLNVKILVEDYELGMGLPLVHPLQMNQIHGLLQTRLDVSANPIKEAFFFLHSFCVSLQLDVLFCQTSRLAAGRLRENITIEKYDTKERVLVVGYWVKRSKSKKLTVGQVKYDAQYRVQIYEDKEDKRGGLKVRHFPHAPQLGKLDCDAGMISMDRLLSDTFLVRCKERVMRLRRIIEAAEPLLEIKMTGFSIPSLQLALLPDSTATEEMLTVSVNSFCGKVLCDLGML |
Length | 317 |
Position | Tail |
Organism | Caenorhabditis japonica |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida>
Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae>
Caenorhabditis.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.098 |
Instability index | 39.96 |
Isoelectric point | 9.32 |
Molecular weight | 36268.31 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
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GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP16440
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 85.63| 22| 75| 36| 57| 1
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36- 57 (39.50/25.11) LNQ...LIETRLSRLSTG.IPPNIKE
114- 134 (24.88/13.54) MNQihgLLQTRLD...VS.ANP.IKE
148- 167 (21.25/10.66) LDV...LF.CQTSRLAAGrLRENI..
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 76.49| 23| 25| 171| 195| 2
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171- 195 (35.39/30.35) KYDTKERVLVvgYWVKRSKSKKLTV
199- 221 (41.10/28.03) KYDAQYRVQI..YEDKEDKRGGLKV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 71.98| 23| 25| 267| 289| 3
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267- 289 (37.44/25.72) AAEPLLEIKMTGFSIPSL.QLALL
294- 317 (34.55/23.23) ATEEMLTVSVNSFCGKVLcDLGML
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