<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16430

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMTDEDWPSLKFREHVIQRLEPELARNRQNAPNLPVPGDARQVEEYVFAKCVSKDEYMRTIAKVINAINCNSKSAAVPSVLQPSQFHSPPCTTAGGTTPVGSTPGYRAAVPPDPQPTSAQVRNPPAPSVATTQASTTPSNPSAVPGSVSVNGGPTGPNSASFPSPDVAALRPSATTPGAAVAAAVAAGAAAPFSNVSAPPSAPMNGGPPMGQPPPQMGAPNMGMGGPPNSYGGYSMMNGPPGSGGPMGGNPYSQQMKTPKEMDQSRPWEPQGHMYQTPQWGSMPQQGHGYPNGPMNGQGNTPTGSSSVLESLINQPQQYPNHHHHPQMAPPPDRNAVQRVAQRPPGMGPPGQQGVMSVEDQNIYNMKLRNMRGSCESLRTRARQCRTEGNHEAAHKLEVMLSVLEGKRVVSLEYLQHLETWIARKQDFLNIAPINHNVPNHMGMGDNVMNGDHGMMGNGQVHNPYGHPGYGHGQYMGAPPPHQMHQMHPSMWHQQQQQQQQQQQQQQQHQQQHRMMQQEHMMVGGPPGAGGGPMHGMYRGDLGHDQMTSPINSHRHAPYQTPVMRNSMRGGGGMPNGPGPIGRDRNSMSGSMSGPNSGASMNPMGTPGPKMGAPGSMGGMPGLDDFVYDDFLPNPVDSLQATLPLGNPQSSMNAGPQTQRANLNEAARKELQAVDSRFEIDPNYQRHDANHIVVSVKIRGQTVPPLRLVVPITYPAGNVTVDRAAIDLDSYLYDDLQNAVYERLSRPGITSLTDYLTAWEEQVSIYSQQQNQSNGLDAPFGVGNDFFYDNLNLSNAF
Length796
PositionTail
OrganismCaenorhabditis japonica
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.06
Grand average of hydropathy-0.738
Instability index52.22
Isoelectric point6.58
Molecular weight85608.66
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16430
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     127.18|      25|      26|     205|     229|       1
---------------------------------------------------------------------------
  205-  229 (56.25/19.39)	GGPPMGQPPPQMG....APNMGMGGPPNS
  231-  252 (39.76/11.08)	GGYSMMNGPPGSG....GP...MGGNPYS
  569-  596 (31.17/ 6.76)	GGGGMPNGPGPIGrdrnSMSGSMSGP.NS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.20|      16|      18|     452|     467|       2
---------------------------------------------------------------------------
  287-  301 (29.92/ 9.19)	HG.Y.PNGPMNGQGN.TP
  452-  467 (33.44/11.32)	HG.MMGNGQVHNPYG.HP
  471-  488 (25.84/ 6.73)	HGqYMGAPPPHQMHQmHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.74|      30|      30|     115|     144|       3
---------------------------------------------------------------------------
   95-  128 (49.09/18.86)	GTTPVG.STPGYRAAVP....pdpqPTSAQVRNPPAPSV
  129-  166 (46.45/17.45)	ATTQAS.TTPSNPSAVPgsvsvnggPTGPNSASFPSPDV
  167-  200 (34.19/10.92)	AALRPSaTTP.G.AAVA...aavaaGAAAPFSNVSAPPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.19|      41|     116|     622|     663|       5
---------------------------------------------------------------------------
  622-  663 (68.36/51.30)	LDDFVYDDfLPNPV.........DSLQATLPLGNPQSSMNAGPQTQRANLN
  727-  776 (61.83/40.67)	LDSYLYDD.LQNAVyerlsrpgiTSLTDYLTAWEEQVSIYSQQQNQSNGLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     169.74|      34|      65|     253|     286|       7
---------------------------------------------------------------------------
  253-  279 (45.73/14.93)	....................................QQMKTPKEMDQS.RPWEPQGHM.YQ.....TPQW
  280-  346 (45.22/14.68)	GSMPQQGhgypngpmngqgntptgsssvleslinqpQQYPNHHHHPQM.AP.PPDRNA.VQrvaqrPPGM
  501-  520 (28.52/ 6.25)	....................................QQQQQQQHQQQH.R.......M.MQ.....QEHM
  524-  563 (50.27/17.23)	GPPGAGG.........................gpmhGMYRGDLGHDQMtSPINSHRHApYQ.....TPVM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.20|      14|      18|      40|      53|       8
---------------------------------------------------------------------------
   40-   53 (24.58/18.97)	RQVEEYVFA.KCVSK
   58-   72 (19.62/13.82)	RTIAKVINAiNCNSK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16430 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVPSVLQPSQFHSPPCTTAGGTTPVGSTPGYRAAVPPDPQPTSAQVRNPPAPSVATTQASTTPSNPSAVPGSVSVNGGPTGPNSASFPSPDVAALRPSATTPGAAVAAAVAAGAAAPFSNVSAPPSAPMNGGPPMGQPPPQMGAPNMGMGGPPNSYGGYSMMNGPPGSGGPMGGNPYSQQMKTPKEMDQSRPWEPQGHMYQTPQWGSMPQQGHGYPNGPMNGQGNTPTGSSSVLESLINQPQQYPNHHHHPQMAPPPDRNAVQRVAQRPPGMGPPGQQGVMSVEDQNI
2) DSLQATLPLGNPQSSMNAGPQTQRANLNEAARKELQ
3) LNIAPINHNVPNHMGMGDNVMNGDHGMMGNGQVHNPYGHPGYGHGQYMGAPPPHQMHQMHPSMWHQQQQQQQQQQQQQQQHQQQHRMMQQEHMMVGGPPGAGGGPMHGMYRGDLGHDQMTSPINSHRHAPYQTPVMRNSMRGGGGMPNGPGPIGRDRNSMSGSMSGPNSGASMNPMGTPGPKMGAPGSMGGM
4) MKLRNMRGSCESLRTRARQCRTEGNHEAAHKLEVM
75
636
428
365
362
671
619
399










Molecular Recognition Features






MoRF SequenceStartStop




NANANA