<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16427

Description Uncharacterized protein
SequenceMSAPGGQQPSLTPQQMEALRMQQMSRNQQQQQQFMQQRQQLMQQQQQQQQGQAVYQRSRTPQQHHQYPQGGSPGGYLQMQPHLQPSGHLQPRSPLVQGAVNQQMGINQQPMSLPPTHISRPASVAPPSSVPTNLHGGVVGGPPSNQMDHPQYQMHHQQLQQQQLQQQTPSRPGSQQSQHMMGPGPQSVQQPGSIQRPGSVMAPGSVQSHGGPLSAVGGPQSVQGYGPASVQQPSSVQPASVQPPGSQQAPSSVQPASFAPGSVQPPASQQPPSSIQPPPSAASATSTAAAGKIEPLKPNEEQIRMVQDPVDLVRNLVQKDLRNSLVEMNRRGAVLVRQREEEGEISQEDKQQYKRAANDFNAVCDEIDRTLTTVMETAKQLSKLDKVFIERSTKELDGEVMVNCVQKFVDNTEIVQKMFDGTIGNVTATMEKIRRREKKWEDLQRKKKENSGDVEMAE
Length458
PositionTail
OrganismCaenorhabditis japonica
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.03
Grand average of hydropathy-0.924
Instability index79.94
Isoelectric point8.98
Molecular weight50278.71
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
lateral inhibition	GO:0046331	IEA:EnsemblMetazoa
positive regulation of Notch signaling pathway	GO:0045747	IEA:EnsemblMetazoa
regulation of cell fate specification	GO:0042659	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16427
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.96|      14|      15|     227|     240|       1
---------------------------------------------------------------------------
  227-  240 (27.37/ 7.53)	PASVQQPSSVQPAS
  244-  257 (26.59/ 7.08)	PGSQQAPSSVQPAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     162.68|      32|      33|      79|     110|       2
---------------------------------------------------------------------------
    4-   35 (37.57/ 8.24)	.PGGQ.QPSlT..P......QQMEALRmQQMSRNQQQ........QQQ.FM
   84-  118 (51.90/14.62)	QPSGHLQPR.S..P......LVQGAVN.QQMGINQQP......msLPPtHI
  119-  155 (33.14/ 6.26)	SRPASVAPP.SsvPtnlhggVVGGPPS.NQMDHPQYQ........M...H.
  175-  210 (40.06/ 9.35)	QQSQHMMGP.G..P........Q.SV..QQPGSIQRPgsvmapgsVQS.HG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.32|      15|     110|      43|      61|       3
---------------------------------------------------------------------------
   37-   51 (30.79/ 6.61)	QRQQLMQQQQQQQQG
   56-   70 (29.52/13.25)	QRSRTPQQHHQYPQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.95|      33|      51|     368|     400|       4
---------------------------------------------------------------------------
  368-  400 (52.65/40.62)	DRTLTTVMETAKQLSKLDKVF..IERSTKELDGEV
  420-  454 (51.30/39.41)	DGTIGNVTATMEKIRRREKKWedLQRKKKENSGDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.48|      19|      29|     259|     278|       5
---------------------------------------------------------------------------
  259-  278 (32.20/16.32)	APGSVQP..PASQQpPSSIQPP
  289-  309 (30.29/11.01)	AAGKIEPlkPNEEQ.IRMVQDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16427 with Med29 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNRRGAVLVRQREEEGEISQEDKQQYKRAAND
2) MSAPGGQQPSLTPQQMEALRMQQMSRNQQQQQQFMQQRQQLMQQQQQQQQGQAVYQRSRTPQQHHQYPQGGSPGGYLQMQPHLQPSGHLQPRSPLVQGAVNQQMGINQQPMSLPPTHISRPASVAPPSSVPTNLHGGVVGGPPSNQMDHPQYQMHHQQLQQQQLQQQTPSRPGSQQSQHMMGPGPQSVQQPGSIQRPGSVMAPGSVQSHGGPLSAVGGPQSVQGYGPASVQQPSSVQPASVQPPGSQQAPSSVQPASFAPGSVQPPASQQPPSSIQPPPSAASATSTAAAGKIEPLKPNEEQIRMVQDPV
328
1
359
310










Molecular Recognition Features






MoRF SequenceStartStop




1) QAVYQRSRTPQQHHQ
2) SLTPQQMEA
52
10
66
18