<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16421

Description Uncharacterized protein
SequenceMVPATISFPTSSTVIDDEDERPEDGVASWYNEQPGERLLRKNNLRMGTADVYKQNRNQEEDMLTPDRLKKGYQPQMPLTQFELQSLVFNASENKLARLDKGQKRTQSMIAMVIYRKGEFNMTFDRDSKIPKEELPALSVYHWRRIISDRVKFFSALGRGVSLQYLSKKIPTFRRKDLLFHEFYDYNIPYDRALWCVNLMCILGFTASNNKQRKTMLDVASLELSQACTKTVIVLLDRFVECFELEGEDKPKKYSEEDNFMDYLKRDRESNVFHVSDDEDEFQEEYFPEELNHAKMSREGRQAEEESIGNAENYEDDEMLKWFKKAQGIHESEEEPESSMEEPIDAKKLDRASENFEELLKMWDYKTGLIKVLFEKGVLDKHEYLNDLCEIFTVYFLKRRVTNPFILQLFMSYFFNYAEAVSHNIILARRAANVLCQEIRVLFDLGEQIRKANHYTDNSGKVLKKKIQLHPHTEYDIFNEDEEEAEAYKKWVEEYGLEYTKAYDAAVKAGVKMEPESDCGSGLDTEEENSVHEEGSEEEEEITEAELYDLFHKKEETELMECDENGKRVLSVPVTTPGKRKRSPIPTSEYIFGFQNLERVKTPPYFGPTRDERAAFQAAAEEKEREEARIRAEKAATEAAEAAKRATAAPDDSAKTVEDIGENLPLNVRIKAEPIDDGYEDEDKLVSYIPPIDFSIHAANVKTEPNDKDYEQAETSFGMPKPPRREYTEEELMEMRAMGMEDMDLETDAEEDAEQHRVLGRASDGNAVAQPESVNTNHPPRETAKERRARQMELDVQEYEERMKSARERTKAEKVVSFVAPQLQPPTKERKKKKKKKSKGKKRSRKGKYQSSSSDSFSSCTSSDSSDLEFNEDEPPPSVLPIHQYDEKYGHIKGSPLPPILAKHYQDETYFWCQSGGVSIDPYNEDELDFSNPTPPPQPPQQSVDFDSSPCESPALDDKDGDTPVKEKKDGDEKERKEKEEEALKNMTAEERTVDTPTSPGYRTRIEIQRLEEAAKEREDEKKRLREERRAKGIVTPEPEKSPGEEESAKESGDGASEASAREKSSSDADAEPNASGNDGKQKTNASGATKPAASAVIGTDKDVEMEDDEKVEDEENLATAQIGIEGDPENEDPEGEVLPMEIDEADEQHSGRKVGGNGEPMEVDEQPGESKVENGEVEFLGTKLFKKPPDPNEVVVIAEIKNNDKKEGEDQKKENDSAGKEKTPEKEEKGESSTNPMQLHDPYNFLGYNSFYSAVPDYRGPSSQPLAPPGQLNDPKIVGMSDESVSHISVTPEERKKRMLQKIKSAQDSYHAHEDRWRTSIIHPGFKIFDKCDAYWDPLLLMSGMLQYVASVAPESLVWNDLLVKNERRRPRMLPQLCGSPLDFLPCELHELPMPEEFDDIVDTLKIRTQEITRRSKAVADKWLPNGADVLKYGRIIDTCVDVIGIMDNIDCEKAGSIENAARRLFKFRPKFQKEEALLRTKLMFKWCITDEREGSFRACYVAKLLRLGMHMTFDETIGGWSVMDLFFNFMKTEGPKYGSKQYQAHFDAAVAIMIEMLREKVFSITEIIEEMEKDEDLDYYEPLMWRQRKQKIPKEPKNRNVAQDETKLIHFRKEHTPKRLFMGKKMDLLERMIIILPQLDIDERETDVYRKRRLLLFGMYPAHNPYYRRARYIFKSISSVLEGKLCIEFDRETRVTTCHKKINQLGLNELLRPFQAQTYHDQHLILERIVHSFIDAVCSFLNKDVHECPAPEIADIICQMYEYSQDIVSIFDFFEKFIPFTKCVDDKLNRFRMDVIPFMYSTEVAFIFVSFFMKHWQRFLLYERACQIVNQCYDVIEDMIRAKGHVITGWGRTVAIFVFHARKCLINAGRQTEEFRAQDEHFWRVFPNTRHHELDVHHFNEEFAATTLSLRAGSLRYNSYDDFKWTLASLKMNRELSPPHRPPSSRYSFVIRAFMEARLHRGYFDRINELANYCATVTANDPPLSEYWIAAIKGLCCLSMDATYPFREMSKEIDISDCSSHYPLVTFITCLAGKSAFYIPRLLSELTKHIFPLMLQTNGRLTSLRTRDVKRKTASKTTDTRSLSEAEPGVCLCLMIICGLCCVGDEPFGLSVHYTGLDPRKKRFGQTADERIMHLFHWFEMDRAMFRTLGYIAQLLDALRSRHKDGNLVLPATFKVKEPKNKQKLQEEIVEGQNQNQKPKSQPAYYRPQFLFNIAKTVLFVICEQDWVTIRMFRFFKTRKMEAFNQDKLKQNCLGQQILRMALRRKTERANVEKLFEAHAVSKKATVDRVLSFMSLWNFRATLFDLMLMIKEISPDGNTRHAQQGAIAADALMSEIGKCCRDMFIFAYNHKAKMPVVKTLTEFRFSDINKYWLIAPLVRMCPKPINIPPQYANTTVGTVAAKFLREAALLMDTPPNTPKDRLSMSAWAMSRIPFINMILTCLRCEKSQQSKDSFLQALYGQLQREMLRDKSKSKVWTNRREHRDCTVLRTTLVSYIYKEILKPTHVEPWGLLLFQLMFHGVITPIRERLVYDTCFDMLQHMVIWCLVDGDSMNHHDRYGTVRVRWLQYSGLMKKIRKESHDKYTDPSREALFRFMPCPKLQTVTMAVKKYQTKPKVVTRLYKKHPPAIGIKSGKYSFLPEEKMKTNAFDHTMEFMADGVYKGGWKYHWFHTTRIDKVGKTVPSILRAALPHQHGPDFQRTQLMPSDNIIDDIYLMPPDIEVTGTIELSEEPMDEGDDDEKTEEEKAAAEKKKREEEEKKKAEEDGDKKSADDGGKKDDKSAESALDKDKDGKEGKDKLDSSASASKKDDKSAKESESEKDKAAEVVVISDSVDSSKELDTPPKAAPVARSSPATRGRGGGRKRNSGARGGPRAKRASSRADPAQATTNAPGWNANMGPGTSGSGAAGNYHSAMRANQTPMSNGSSDETKANIRNFVNRKQEKRNSTNAANAAAAAAAAASGSSGLMVPGAPGAPGTQMSGASAMTGIPPSQPSMSMMGGQQLPGMNTLRPTNPMGMPGGNPMMNPAMGQGMGQPGMGMDPSGMGQPGMGMPQGMSQPQQAPPPYSSSTAMGQPPMYPNQPHFAAPNPGPINRPNPNAPPNTAEYRKQMMDKEMQNKLAQHQQVFDQQKLNRDARARADAEARERQANEQKMRMEQIRIQEEEKRRAIDENNRRIEEARLAREREEQAARQARMEAARQEALLLEQQRQQREREEQNRLQRERDEQMRLQRERDEQLRIQRERDEQARLQREREEQERLQREHEEKMRIQREREESERRERERIQREIEEKARREAEAERQRLAQEQREREERDAREREAAKAREAADMARRMEMQRQQQAQQNQYMGQQQQPPAYGQQPQGQPPSYQQNSYPSGYNQPGQQQPGQPNQPPSYQQPSHGMQQPGQQPPAYQQGNQMQMNMQQQQQQQQQQQQQQQQNRGQMQPQQQPAYGAPTMNQQRTPSEFASFAGQNQAAQMAQGQAGQAQAQRNMFAGQPDNKTGAMAGMANQNMFAQQQKPNDMHTQQYQHTQNQMLKTLREREAQYMQAKMQNTQANAAGNAAGLGRNMSSSFGQAQAGSTDFAAQAAQMQAANKNTANQQQAARMQMPGQGQPGLGQNPAMVPGMQGYQQPVLGQPGPIQTGQQQQQQQPGANPAGAQPPQQQQQQQQNYAQQQQQQAQRPNVIPTKNEMGGVRMEGRNSGGGMANQMAQGYGQQNAARFPPGQQAAGQPAQPGQTPANYPNQQSQQQQKPQQQFSATGTNPQMGQMGQQAPQQQPGFQQGAYPQQGMQQQQQYPGANPAQNQMRQQQQAQMQQAQQQQQQQPNQPQQQQQPQNQFQQQAQPGQYARNAQGQQPQQQQHGQYGQNQQFTGQYGQQPVAQNNPQMLQQQNQQNAQQQQQQANRYGGMGGYSGGNTSNILAQSMEESGLNIPGAHSKPSQGGAPQDGNNMMQPQQPGFERAGMQNAQNPMLMQQQQQQQQQRMAQSGMGVAGQMPQQPAQQGMSRPGMGMGMGQGQPQAQAAQVQQAQQAAQLQQQQQQRAMMAGAQLPPYSMGQAQAQDPYRMGMQPGQAQNPNQAQQMRMQQGMAPQPQPGYGQQMQMPPIQHRGQGPQAHGMGTMGHNNMQQQQQQAGAAQYYQQQQPDQRMQQQPGQQQPQHGYGMGQYPNQQHPY
Length4165
PositionKinase
OrganismCaenorhabditis japonica
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.07
Grand average of hydropathy-0.958
Instability index54.45
Isoelectric point6.17
Molecular weight474690.89
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16421
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            14|    1221.59|      79|      79|    3743|    3821|       1
---------------------------------------------------------------------------
 2974- 3036 (61.09/11.78)	...................................APGT.......QM..S...GAS..AM.TGIPPSQ....PS.MS..MMGG..QQ....LP.....GMNtlrptnpmgmP.G...GN..P.M.............MNP.....AMGQG...M...GQPG
 3057- 3131 (82.07/18.11)	Q...............PQ....QAPP....PYSS.STA.........M..G.Q.PPM..YP..NQPHF...AAPN.PG...PIN..RP....NP.....NAP..........P.N...TA..E.YR...KQmmdKEMQNKL.....AQHQQvfdQ...QKLN
 3143- 3217 (57.39/10.67)	R...............ER....QANE....QKMR.M.....E....QI....RIQEE..EK.RRAIDENNRRIEE.AR..LARE..RE....EQ.....AAR..........Q.A...RM..EaAR...QE...ALLLEQQ.....RQQRE...R...EEQN
 3277- 3355 (66.35/13.37)	E...............RR....ERER....IQRE.IEEKA.R....RE..A.EAERQrlAQ.EQREREERDARER.EA..AKAR..EA....AD.....MAR................RM..E.MQ...RQ...QQAQQNQ.....YMGQQ...Q...QPPA
 3358- 3439 (107.96/25.92)	Q...............QP....QGQP.psyQQNSyPSGYNqP....GQ..Q.QPGQ....P.NQPPSYQQ...PS.HG..MQQP..GQ....QP.....PAY..........Q.Q...GN..Q.MQmnmQQ...QQQQQQQ.....QQQQQ...Q...QNRG
 3440- 3495 (74.62/15.87)	Q...............MQ......PQ....QQ.P.AYGA..P....TM..N.Q..QR..TP.SE........FAS.................FA.....G..................QN..Q.AA...QM...AQGQAGQ.....AQAQR...NmfaGQPD
 3496- 3590 (57.84/10.80)	NktgamagmanqnmfaQQ....QKPNdmhtQQYQ.HT.........Q...N.QMLKT..LR.E.....REAQYMQ.AK..MQNT..QA....NA.....AGN..........A.AglgRN..M.SS...SF...GQAQAGS.tdfaAQAAQ...M...QAAN
 3596- 3672 (102.63/24.32)	Q...............QQaarmQMPG....QGQP.GLGQN.P....AMvpG.MQGYQ..QPvLGQPG.....PIQ.TG..QQQQ..QQ....QP.....GAN..........P.A...GA..Q.PP...QQ...Q....QQ.....QQQNY...A...QQQQ
 3673- 3739 (78.68/17.09)	Q...............QA....QRPN.........VIPTK.N....EM..G.GV.........RMEGRNSGG.....G..MANQmaQG....YG.....QQN..........A.A...RF..P.PG...QQ...AAGQPAQ.....PGQTP...A...NYPN
 3743- 3821 (165.37/43.24)	Q...............QQ....QKPQ....QQFS.ATGTN.P....QM..G.QMGQQ..AP.QQQPGFQQGAYPQ.QG..MQQQ..QQ....YP.....GAN..........P.A...QN..Q.MR...QQ...QQAQMQQ.....AQQQQ...Q...QQPN
 3824- 3898 (100.85/23.78)	Q...............QQ....QQPQ....NQFQ....QQ.A....QP..G.QYARN..AQ.GQQP..QQQQHGQ.YG..QNQQftGQ....Y......GQQ..........PvA...QNnpQ.ML...QQ...Q..N.QQ.....NAQQQ...Q...QQAN
 3899- 3979 (79.26/17.27)	.................R....YGGM....GGYS.GGNTS.NilaqSM..E.ESGLN..IP.GAHSKPSQGGAPQ.DGnnMMQP..QQ.....PgferaGMQ..........N.A...QN..P.M............LMQQ.....QQQQQ...Q...QRMA
 3980- 4070 (81.56/17.96)	Q......sgmgvagqmPQ....QPAQ....QGMS.....R.P....GM..GmGMGQG..QP.QAQAAQVQQAQQA.AQ..LQQQ..QQqramMA.....GAQ..........L.P...PY..S.M.........GQAQAQDpyrmgMQPGQ...A...QNPN
 4071- 4137 (105.93/25.31)	Q...............AQ....QMRM....QQGM.APQPQ.P....GY..G.QQMQM..PP.IQHRG..QG..PQaHG..M..................GTM............G...HN..N.MQ...QQ...QQ.QAGA.....AQYYQ...Q...QQPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.23|      28|      29|    3218|    3245|       2
---------------------------------------------------------------------------
 3218- 3245 (54.18/27.18)	RLQRERDEQMRLQRERDEQLRIQRERDE
 3248- 3275 (54.04/27.09)	RLQREREEQERLQREHEEKMRIQREREE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     104.23|      16|      18|    2767|    2782|       3
---------------------------------------------------------------------------
 2751- 2766 (19.18/ 7.94)	KK.KREEEEKKKAEEDG
 2767- 2782 (26.45/14.45)	DK.KSADDGGKKDDKSA
 2787- 2803 (19.27/ 8.02)	DKdKDGKEGKDKLDSSA
 2809- 2824 (19.51/ 8.24)	DD.KSAKESESEKDKAA
 2834- 2849 (19.82/ 8.52)	DS.SKELDTPPKAAPVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.38|      49|      69|    2853|    2903|       4
---------------------------------------------------------------------------
 2853- 2903 (86.27/40.90)	PATRGRGGGRK...RNSGARggPRAKRASSRA..DPAQATTNAPGWNANMGPGTSG
 2920- 2973 (75.11/30.77)	PMSNGSSDETKaniRNFVNR..KQEKRNSTNAanAAAAAAAAASGSSGLMVPGAPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16421 with Med12 domain of Kingdom Metazoa
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