<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16410

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMSRLQRQSPPEQKQQPSQPQVSTQIPAEALEPIRNRLSQVHQSLRKLADQINLHNRNPAKVKLPSYSNLQSQFQVLITQLQTIAARLDTNDEILKSTNVYPVPSFPTTQHEGLVTTLLRKKPLPEVDEWIDAAIAESESFKLPIHADDEFAEWCYAKVKELEDEFTFEGFHTEEELQLMETEEGQKNEEEKTAAETENKKTIDEISGGKKPMSPNTVLRFMTRGVL
Length226
PositionHead
OrganismCandida auris (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade.
Aromaticity0.06
Grand average of hydropathy-0.759
Instability index62.43
Isoelectric point5.11
Molecular weight25821.74
Publications
PubMed=27988485

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP16410
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.25|      23|      23|     128|     150|       1
---------------------------------------------------------------------------
  128-  150 (41.09/29.82)	EWIDAAIAESE.SFKL.PIHADDEF
  152-  176 (34.16/23.69)	EWCYAKVKELEdEFTFeGFHTEEEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.26|      21|      23|      17|      37|       2
---------------------------------------------------------------------------
   17-   37 (34.61/23.81)	SQPQVSTQIPAEALEPIRNRL
   43-   63 (33.64/22.96)	SLRKLADQINLHNRNPAKVKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.98|      15|      18|      89|     103|       3
---------------------------------------------------------------------------
   89-  103 (26.94/20.22)	TNDEILKSTNVY..PVP
  108-  124 (22.05/15.29)	TQHEGLVTTLLRkkPLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16410 with Med8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSRLQRQSPPEQKQQPSQPQVSTQIPAEALEPI
2) TEEELQLMETEEGQKNEEEKTAAETENKKTIDEISGG
1
172
33
208










Molecular Recognition Features






MoRF SequenceStartStop




1) KKTIDEI
2) RFMTRGVL
199
219
205
226