<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16406

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMFGNYLVCKSSDEIRQYSIVQIDPVVLENGDMLVSLSQMNRIALWGTDIVNTNMISSDITNTFVIYVIPSGLRCHFFSVHDFSQTFTVTPPKSSGNLLRLLKLSTGIDLSERTEILWVKLIPNLQHLNNQTSDISSFIHEVDNKKFILWPWELCLLQFGYEDSRLEEKQQGPSSTDPLQLIHRFIDSLAFEKEEFTSRNGPPFTNSNANAHSTSNMFNYNVPSSISTGRSSGQGTMPEFLQIKSDTPAASVSESNGRQNVSQLEESQQGDTEERSRMQPDTAKSGVKADDDKFHDSKTTETKGEAHMDDINDDEDLFGESSGSEDVDSSTISKTDKDRADRASSNVNATYSKEHSSVKQMAPSTAENTSSCADEEHINETSMSPTTFVNIPKDQMISDIESIPSSYKDPGAPLPIVPTPIIPQHSNLGVGPNDYSNLSKLSSLPHRARLRLERAREPLNNPERQGYVFSPLRFNPVIKSSIDTKYGKGGKFYVSQNANQDYEQKVRRPRETSVSHGSPIQLANDENILGDMPFFNSGRDPGHEASFVKPQPSESHESTETQHQDDARETDNDDEEESDFDEDYDDHELKTSPLQLNISNQDPQIGLSSTYDALDTQNSNHPTLFPHTSMLSPSNEESKNKLSTFESPPPPNSLGNIQGSVMSPVFASQFGNKDDSTVPGSDMKDGEASLAPTSSMSPLNSSSNAMGESSNCLPLILRSINVLTIPPEFIVERKRERWDDVTMSSGFDITVMEDMEDINDGRFGHLSVKSKNIEEYLKWVTNNVVFDFGGFEARNSSKIKLPSESIVHDDTPESEPSELVIDTFKNIFPLSFRMGLDEFRFGHNFSTSAENHEDPTKKNEMDLLERMNDNVELAGSVSQDMRQLSWDSIYHDVGENKKNALQSMVLLDEARQKWETHKGEDDAFTSLHDVKVKVIKNASDEINLDFLGLRFWHYLKFKPIHKPRNFQVLLISESSSAGNDRTTLDGGNLSFLSLLRNNYKDNHFGDIKRLSLQVPDDRQDLEGLTNGIISAENVLNDATYGKYYGMINRTLKSLAELIKLDLINKINRFDFDRPLLLLFISFDRSLSSLSSISKLCRNFKTALSNQHLSLVDLFCHIIPGDLIMKQCGQERRLRYLSNTQMTNISMLLYNKCPSQKISTSLRKKLEVTELYTRLVKESPVALNSKIYNRSMNADGGVALLDDLFLHVAYERSIDRRWVSAAWSDPHGAVIRTKSWLCSTKKPSSSASHDIGAIIGEIWDVSSSLFKILNDDDSRRACTTGGKRYLVLTRINSILPDDELVFWKRLTTKYKEMSLIVLSANRMPKASFNLEDSCSQPTASCGQSPKSMPANQKGKLYGLPSSHGSELLGTFGESGVPYTSSPANADMNSTSPINSGGITVQSPNQFMNLSANFLSPQDCGPSGQLPESTTNDEANLVLQDESLEIMGFIPQTSLPSTNSPTRLAMRNGYLIKTQERSDAPKVPKILVFEVSLLSCSNHWNVNNLMKILLNQLKKLIYLNQVVGVCDIGDNFVSGNFSRGTHKKTIRSIIPWHINAVGKCLDYLVHIRVDEDPLA
Length1572
PositionKinase
OrganismCandida auris (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade.
Aromaticity0.07
Grand average of hydropathy-0.537
Instability index50.27
Isoelectric point5.23
Molecular weight175623.27
Publications
PubMed=27988485

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP16406
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     205.50|      64|      82|    1315|    1385|       1
---------------------------------------------------------------------------
 1315- 1385 (95.32/96.77)	VLSANRMPKASFNL..EDSCSqPTascGQSPKSmPANQKGKLygLPSSHGSELLGTFGESGVPYTSSPANADM
 1398- 1463 (110.17/80.94)	VQSPNQFMNLSANFlsPQDCG.PS...GQLPES.TTNDEANL..VLQDESLEIMGFIPQTSLPSTNSPTRLAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     247.13|      59|      82|     498|     558|       2
---------------------------------------------------------------------------
  379-  419 (41.39/16.11)	............ETSMSPTTFVNIPKDQMIsdIESIP...S.SYKDP...GA.PLPIV.PTP.....
  498-  556 (100.81/53.30)	NQDYEQKVRRPRETSVSHGSPIQLANDENI..LGDMPF.FN.SGRDP...GH.EASFVKPQPSESHE
  562-  620 (67.67/29.14)	HQDDARETDNDDEEE....SDFDEDYDDHE..LKTSPLqLNiSNQDP.qiGL.SSTYDALDTQNSNH
  621-  663 (37.26/13.68)	..........P..TLFPHTSMLSPSNEES...KNKLST.FE.SPPPPnslGNiQGSVMSP.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.58|      17|      77|     761|     777|       3
---------------------------------------------------------------------------
  761-  777 (29.03/17.54)	RFGH.LSVKSKNIEEYLK
  839-  856 (26.55/15.39)	RFGHnFSTSAENHEDPTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.62|      35|     102|     979|    1016|       5
---------------------------------------------------------------------------
  979- 1016 (56.15/39.97)	DRTTldgGNLSFLSLLRNNYK....DNHFGDIKRLSLQVPDD
 1082- 1120 (56.46/32.44)	DRSL...SSLSSISKLCRNFKtalsNQHLSLVDLFCHIIPGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.76|      19|      83|    1129|    1159|       7
---------------------------------------------------------------------------
  209-  227 (36.62/14.81)	NAHSTS.NMFNYN.VPS.SIST
 1137- 1158 (24.14/20.83)	NTQMTNiSMLLYNkCPSqKIST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     122.32|      29|      69|     232|     260|       9
---------------------------------------------------------------------------
  232-  257 (35.96/20.23)	.........GQGTMPEFLQIKSDTPAASVSESNGR
  258-  292 (36.53/20.68)	QNVsqleesQQGDTEERSRMQPDTAKSGVKADDDK
  303-  323 (25.81/12.10)	.........GEAHMDD...INDDEDL..FGESSGS
  324-  346 (24.02/10.67)	EDV......DSSTISKTDKDRADRASSNV......
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16406 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DIESIPSSYKDPGAPLPIVPTPIIPQHSNLGVGPNDYSNLSKLSSL
2) FTSRNGPPFTNSNANAHSTSNMFNYNVPSSISTGRSSGQGTMPEFLQIKSDTPAASVSESNGRQNVSQLEESQQGDTEERSRMQPDTAKSGVKADDDKFHDSKTTETKGEAHMDDINDDEDLFGESSGSEDVDSSTISKTDKDRADRASSNVNATYSKEHSSVKQMAPSTAENTSSCADEEHINETSMSPTTFVNIPKDQ
3) KGGKFYVSQNANQDYEQKVRRPRETSVSHGSPIQLANDENILGDMPFFNSGRDPGHEASFVKPQPSESHESTETQHQDDARETDNDDEEESDFDEDYDDHELKTSPLQLNISNQDPQIGLSSTYDALDTQNSNHPTLFPHTSMLSPSNEESKNKLSTFESPPPPNSLGNIQGSVMSPVFASQFGNKDDSTVPGSDMKDGEASLAPTSSMSPLNSSSNA
398
195
487
443
394
704










Molecular Recognition Features






MoRF SequenceStartStop




NANANA