<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16405

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPISERNPPLTRSGYLNALSKRSSAISWSKYGFITYAHPDPSSGHNMCLTYLENTNGKDWQLAKATEIALKPSDGGSVAEIDRLKWSNLSTDLAVWDVHGNFYILLAGVGLINDKKEKEMNGSHGPANGSGPSPPPKRDNDGPSYELTSYNHIEMIYRDIVPPQAHTKCVAFEWLNIQKPQIINKPATLTNVDESGYAHYAYGVQQHHPPGPSHPISTKQACLAVRQNGLLNLYYQGEHKVEYHKLAYNLAPDGREGSCTFTKAAIGFNSDKKLVICAYDARSDLILTYVVSIDWGYLVDSAQRQRSDPHYHTPKDGQNQPSLSCSLVHEMRPEPTAFCDNEDDKQFGRPEVVQQTLKSIELFSPSFQQDSCLEILITYECMDPVGSQPYTSAYRYNLEPAMDAVGDLFDSMAAENSNESREGISRLVLQGRINLSKQVQQIETAISESLLLFIYNDGSIDSINRETWEVMQPPEVKIEGKESSNAFPSTIMSLLDCGFQFPTLGPSPNLLAISPNMAAFVHYTDGRLQYKALEQFNSGSNTSLCGIGFAYMHACACYSTTSSDDLLVMLRNELYKVESLVPDSAADLIDLVMTESHKAINFQLNSFGKESVDKLLSNPPLQRLLSLQLVLGELHPTNRAIRDMAWIVLNLRSTSFGIMFSLSSIYRQMSKKKPAEDLLQDSVSRAECIMSLVGNVRWLIDLIVYFNQELLQLSFSRSRPAQSKVTLDNSVVLPVILGKVPRLFLMYSLSSIGKTHEILKKLYKELNESNKLFTPMKEALNRFFTACNSSPLNLGLFESFLRECELYVNKELNNVVSNDRNQSLRLEQQLFCRGFIPEVVKYMAKVLIDRHAATISRDLKLSDLYFYENDWIDVGIARKTLPVPSAMSDDGYNPTIPRLRYSDSEVVDALRKIIINAAPTIPSGGATALGKGYSSKNKIRKCTRCKAVSLVADPTIFDGAGGLGVWTMVFQRTCICGNAWVNCS
Length984
PositionTail
OrganismCandida auris (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade.
Aromaticity0.09
Grand average of hydropathy-0.265
Instability index50.18
Isoelectric point6.13
Molecular weight109805.78
Publications
PubMed=27988485

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16405
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.45|      18|      31|     676|     693|       3
---------------------------------------------------------------------------
  676-  693 (30.86/19.98)	EDLLQDSVSRAECIMSLV
  708-  725 (30.59/19.74)	QELLQLSFSRSRPAQSKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.02|      13|      32|     917|     930|       4
---------------------------------------------------------------------------
  917-  930 (19.88/18.18)	AAPTIpSGGATALG
  952-  964 (26.13/17.42)	ADPTI.FDGAGGLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.02|      24|     169|      31|      54|       5
---------------------------------------------------------------------------
   31-   54 (47.48/25.22)	YGFITYAHPDPS...SGHNMCLTYLEN
  202-  228 (38.62/19.25)	YGVQQHHPPGPShpiSTKQACLAVRQN
  377-  397 (31.92/14.73)	...ITYECMDPV...GSQPYTSAYRYN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.69|      30|      32|     777|     807|       6
---------------------------------------------------------------------------
  777-  807 (50.05/33.74)	KEaLNRFFTACNSSPLNL..GLF.ESFLRECELY
  810-  842 (42.64/24.12)	KE.LNNVVSNDRNQSLRLeqQLFcRGFIPEVVKY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16405 with Med16 domain of Kingdom Fungi
Unable to open file!