<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16401

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDVQSESTLQNGSTSGKASTLPELPHVTNNIIPLSNVLRFYTQEAYKQLSRSIENLANAKTSESDISRKRKFLEVIVSLRRDFIKIYTLVKWAQNSRDVSKLIDLLNYFRQQEFYFENLSIGINELNNFSGAKLPDSDIFTAIEILIKGRPQLPSYNFIPRAPVSPEKILEVLKDINMTLTARMALIEDMPSRFKNNYEIKDGRVIITIPNEFQVSITVGNDLIIDSEQDYYKSPFFFIDFAFLFGINPDTGFITHKDSRIITRLPKSSRDKLETVMNQVLLTQSLSGLYDTLHKYSISFKLYLISRQLRDLSVQSKWKNNIQFRYSSCLVIINYWSKNYFSRDWKSFIEIGIDRHYNLNFRWFKNGKYNLNHNIENITGDDNDDVQDLSVDLILSLIINKHSEILMRKIFERISLQFPPDACSSINPYQLLIQVTPGKSTILAINPLTGFFYFMDPSPIQAQIQNRINSPPSGTKTNTFLSENDIITNVVHHLLHLRLESLSETINNQLISSEWIANDIIKLNETETSKLYSNSKIPQDTDVPKRPRKLQFYRCRNWPTFSFLICSIDGVALQTQWWVSRLKSMKGEWRIQWMQKLKPSQESGYSYAFFKDLSKLGSNLIVDHIIVEELQARKIDYISFSDEIAISHFDLPFKLETSPTKYESIFVLFNQGKLLPVSVSSTSIFLRVSLSSDDLSTKMDLSLSGSLRNLSEADIGVLEKLDVDIKAEKEKFEIRSVVDLSRKSMDSQESDGAHKFLGKLFLHLEKVDSLVRLLYQLRKTNIFVTTTSINQLEFTIDPVYEQFHLKLPVNDQETPELTTGDHEEDSVKVLTRFLNRQIAESHEALVGSIRYLKEFAPVVGAAKKIRMHLLDKEIPKLPNKLSKLQFEVKLQHLNSFQFVFYHNTTNPNAPKKTQKNRISFAMSYATNKFDNEARLFYKFSMKENLNSQNLRYKPLFEMIFKAASELQQEIQKDSTRGLLVKLNYDFLVDHSILEALLLKIADCFLSYIQNES
Length1012
PositionTail
OrganismCandida auris (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade.
Aromaticity0.10
Grand average of hydropathy-0.299
Instability index41.69
Isoelectric point8.45
Molecular weight117093.69
Publications
PubMed=27988485

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16401
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     187.44|      62|     266|       9|      97|       1
---------------------------------------------------------------------------
   31-   96 (91.96/83.69)	IIPLSNVLRFYTQEA..YKQLSRSIENLAN...AKTSESDISRKrkfLEVIVSLRRDfIKIYTLVKWAQNS
   99-  165 (95.49/39.84)	VSKLIDLLNYFRQQEfyFENLSIGINELNNfsgAKLPDSDIFTA...IEILIKGRPQ.LPSYNFIPRAPVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.57|      20|     266|     303|     324|       2
---------------------------------------------------------------------------
  281-  300 (33.49/18.81)	LLTQSLSGL.YDTLHKYSISF
  304-  324 (30.09/19.19)	LISRQLRDLsVQSKWKNNIQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.48|      28|     267|     590|     650|       6
---------------------------------------------------------------------------
  613-  640 (47.00/80.17)	LSKLGSNLIVDHIIVEELQARKID.YISF
  979- 1007 (42.48/ 8.63)	LVKLNYDFLVDHSILEALLLKIADcFLSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     244.70|      89|     103|     677|     779|       7
---------------------------------------------------------------------------
  677-  779 (114.46/117.43)	VSVSSTSIfLRVSLSSDDLSTKMDLSLSGSLRNLSEADIGVLEKLDVDIKAekeKFeirsvvdLSRKSMDSQES.DGAHKFLgKLF...........LHLekVDSLV.RLLYQLRK
  782-  883 (130.24/91.25)	IFVTTTSI.NQLEFTIDPVYEQFHLKLPVNDQETPELTTGDHEEDSVKVLT...RF.......LNRQIAESHEAlVGSIRYL.KEFapvvgaakkirMHL..LDKEIpKLPNKLSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.49|      16|      18|     504|     519|       8
---------------------------------------------------------------------------
  504-  519 (28.05/18.58)	ETINNQLISSEWIAND
  525-  540 (27.44/17.99)	ETETSKLYSNSKIPQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.74|      19|     360|     541|     563|      10
---------------------------------------------------------------------------
  541-  563 (32.12/27.49)	TDVPKRPRKLQfyrcRNWPTF..SF
  904-  924 (29.62/14.83)	TTNPNAPKKTQ....KNRISFamSY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16401 with Med14 domain of Kingdom Fungi
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