Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MTEPIAEGRDSYYLIDTNAQYSSPKPSPLDNLLKLYGLEPIAKSLERTKPDGSKGVKLRKSYKNHIQDLPGKHQIPPAKPVPAALLDPNLSQQPDLIRELDAEMLGNALKFEKTPVSGIPGFNTADLAISDQSTLMRGDDMSENEENRRKRKKQAAHHDVKRQHV |
Length | 165 |
Position | Head |
Organism | Candida auris (Yeast) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.867 |
Instability index | 45.60 |
Isoelectric point | 8.71 |
Molecular weight | 18432.70 |
Publications | PubMed=27988485 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP16398 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 117.88| 37| 37| 77| 113| 1 --------------------------------------------------------------------------- 77- 113 (63.32/43.49) PAKPVPA.ALLDPNLSQQPDLIRELD.AEMLGNALKFEK 115- 153 (54.56/36.55) PVSGIPGfNTADLAISDQSTLMRGDDmSENEENRRKRKK --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IAEGRDSYYLIDTNAQY 2) LDNLLKLYGLEPIAKSLE 3) VKLRKSYKNHIQDLPGKHQ | 5 29 56 | 21 46 74 |
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