<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16385

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAEVGQETLDFGALVARAAEESYVSLKELVEKSKSSESLSDSEKKIMILKYIVKTQQRMLRLNVLAKWCQQVPLIQYCQQLASTLSSHDTCFTQAADSMFFMHEGLQQARAPIYDVPSAIEVLLTGSYQRLPKCIEDVGTQSTLNEDQQGPALKKLDMLVRSKLLEVSLPKEFTEIKASDGVVLLRVDGEFKVLVTLGYRGHLSMWRILHLELLVGERNGLVKVEESRRHVLGDDLERRMAASENPFVTLYSILHELCVALIMDTVIRQVKALRQGRWKDAIRFELISDGTSGQGGSAASSHGTQDGEIDSAGLRTPGLKVIYWLDLDRGTGAPDVGASPFLKIEPAPDLQIKCSHSTFVIDPLTGKEADFTLNRSCIDVEMLLLRAIGCNRYTRLLEIYKELEKNAQINRTPDDVQLQFHLDDYETDYEKRDNVFALQKHDDQEVLRVRAYGASFFTLGINIRNGRFLLRSPKNIISSKALLECEEALNQGSINAVKAFIDLRRNSVLHLFACIGRFLGLEVFEHGYTAAKLPKNISDDSNSLLMGFPECGSSYFLLMQLDKEFKPCPKLIEAQVDSSGKAEPFGDISKVIRVKNLDISRMHMCEDELNLSLLDCRKMLSNSNDVNINGNSESGHPSNSSLEGSMRRSNIPINFSSIVDEVFELEKDSNGQSASSTYGLSSASHFGLGTVNLHGAKPSSPSPNWEGAQTSQNALSNFKSSMQSGSTNSLASTLAKSQAVKKLTASKSDQDLPALRSPHSGGFGSYGIMDEDQLTVSGLPSARLLSPPQRIGPPAVSVKSEPKNLPAGPVSGSNSWVPSPSSSTLDSAALENSNQESIPQNLQNNGRTRKRTVSDMFKSLPSLHYLKANETSNKRRKIKGGPHPQLPSTRLLISHDHPIGTEGHSFANLIAEANKGNASPSIYVSVLLHIVRHCSLCIKHGRLTSQMEALDIPYVEEVGLRSASSNLWFSLPFSRADTWQHICLRLGRPGSLEWDVKIIDPHYKDLWELQKGSNNTPWGSGVRIANTSDVDSHIRYDSEGVVLSYNSVEADSIKKLVADIQRLSNARTFALRMRKLLGARTDEKLDESNASIDSRAPSGLKTVEGSEKFSEQMRRAFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCRMHVSPDQLWPHTKFLEDFINGGEVASLLDCIRLTAGPLHALAAATRPARAAPVSGVPGITASMPSTLKQTGYVPSPGLPSNSNATTSQASSGPGGNPGVSTPSGPPGTHNTAAVLAAAAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKNFAVDMRCFAGDQVWLQPATPPKVGPPTGGSLPCPQFRPFIMEHVAQDLNGIDSSFPGAPQALGMSNSNNPNPSSAPQLPATPGNRANIANGAAMSRTGNAITALNRIGNALPGSSNLPAVNPLRRPPGSGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHSQQQQQNSATAQEELTQAEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQVQGADAAAAPAQKSRIELCLENHMGFNRDGTAENSSVSKSNIHYDRAHNSVDFALTVVLDPAHIPHINAAGGAAWLPYCVSIRLRYSFGENPTVSFLGMEGSHGGRACWLRVDDWNKCKQRVARTVEVNGSSGGDTNQGRLRVVADSVQRTLHTCLQELRDGIGMT
Length1783
PositionTail
OrganismHandroanthus impetiginosus
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Lamiales> Bignoniaceae> Crescentiina> Tabebuia alliance> Handroanthus.
Aromaticity0.06
Grand average of hydropathy-0.242
Instability index45.89
Isoelectric point7.73
Molecular weight194092.24
Publications
PubMed=29253216

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP16385
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.78|      38|      60|     620|     657|       1
---------------------------------------------------------------------------
  620-  657 (66.62/35.73)	LSNSNDVNING.NSESGHPSNSS..LEGSMRRSNIPINFSS
  680-  720 (58.15/30.23)	LSSASHFGLGTvNLHGAKPSSPSpnWEGAQTSQNALSNFKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     123.08|      23|      27|    1232|    1254|       3
---------------------------------------------------------------------------
 1232- 1254 (42.00/21.08)	NSNAT.TSQASSGPGGN............PGVSTPS
 1261- 1282 (32.27/14.38)	NTAAVlAAAAAAGRGG.............PGI.VPS
 1390- 1420 (23.49/ 8.34)	NRANI.ANGAAMSRTGNaitalnrignalPG....S
 1422- 1438 (25.32/ 9.60)	NLPAV...NPLRRP...............PGSGVP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.19|      13|     157|     955|     971|       6
---------------------------------------------------------------------------
  955-  971 (19.29/18.43)	VEEVGLRSassnLWFSL
 1119- 1131 (25.90/14.52)	IEAVGLMS....LWFSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     265.27|      55|     555|     785|     840|      10
---------------------------------------------------------------------------
  734-  781 (58.44/25.65)	LAK..SQAVKKLTAS...KSD...QDLP......AlrSPHSGGFGSYG.IMDEDQLTVSGLPS.......
  785-  839 (92.90/46.97)	LSP..PQRIGPPAVS..VKSEP..KNLP......A..GPVSGSNSWVP.SPSSSTLDSAALENSNQESIP
  847-  891 (38.99/17.43)	.......RTRKRTVSdmFKSLPslHYLK......A..NETSNKRRKIK.GGPHPQLPSTRL.........
 1321- 1382 (74.95/35.86)	LQPatPPKVGPPTGG..SLPCP..QFRPfimehvA..QDLNGIDSSFPgAPQALGMSNS..NNPNPSSAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.34|      31|     680|     368|     413|      12
---------------------------------------------------------------------------
  368-  399 (48.16/70.44)	EADFTLNRScIDVEMLLLRAIGCNRYTRLLEI
  433-  463 (53.18/33.47)	DNVFALQKH.DDQEVLRVRAYGASFFTLGINI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.62|      19|     261|    1443|    1462|      14
---------------------------------------------------------------------------
 1443- 1462 (34.05/24.21)	GElNTAIIGLGDDGGYGG..GW
 1706- 1726 (35.57/20.49)	GE.NPTVSFLGMEGSHGGraCW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16385 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FPGAPQALGMSNSNNPNPSSAPQLPATPGNRANIANGA
2) TGYVPSPGLPSNSNATTSQASSGPGGNPGVSTPSGPPGTHNTAAVLA
3) TVNLHGAKPSSPSPNWEGAQTSQNALSNFKSSMQSGSTNSLASTLAKSQAVKKLTASKSDQDLPALRSPHSGGFGSYGIMDED
4) VSGLPSARLLSPPQRIGPPAVSVKSEPKNLPAGPVSGSNSWVPSPSSSTLDSAALENSNQESIPQNLQNNGRTRKRTVS
1361
1221
690
776
1398
1267
772
854










Molecular Recognition Features






MoRF SequenceStartStop




NANANA