<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16374

Description RNA polymerase II transcription mediator
SequenceMQRYHAGNCTSAVNNSAITGIQGRDTSRADSSTIPSNFSLNSRLGPPDFHPPTPNCPEETLTREYVQHGYKETVDGLEEAREISFSQVQAFDKSTIIKCKEAIRKYHRAINESRAQKRKAGQVYGVPLSGTLLTKAGIFPDQRPCGEDFRKKWIEGLSQPHKRLRSLADHVPHGYRKKSLFEVLIRNNVPLLRATWFIKVTYLNQARAISSNSSSGYHDKPQLSRSEQWTRDLIEYLQHLLDEFIARNNSHSTSHMRDRSSQMVFAGSVQQKADSFSAVMDGEEPSLYTKWWYVVRIIHWHHAEGLIVPCLIIDWVLNQLQEKELLSVLQLLLPIIYGVIETVVSSQSYVRALVGIAVRFIQEPSPGGSDLVDNSRRAYTTAAVYEMLRYLILAVPDTFVALDSFPLPTSVISHVVNDGSFLSKMAEDARKVKYGQVDVAGVHRDRNYEVQAESLSFQSVVSSIQKRAETLSRAAKPNRPAHNVAKALQVLDQTLMHGDIRDSYNLLLENTWDGVCAERWGAEVSPCLHTSLKYIGRVTSSLLCSIFFICEWATCEFRDFRNAPPHGVKFTGQKDFSQVFIAMRLLKLKTSNMPNLYRSNKKNKDISDIFESPSPLHDVIVCWIDQHEVHNGQGFKRLQLLIRELIQSGIFNPLAYGRQLIVSGIMDGNGSMADLEKQKRHYKLLKQLPAPYIRDALEEAQVAEPQTLLEAMNVYSNERRLVLNGLSGHGKSGSGSVSAVKKQKYHHRSGSGSASPHSVDQMYSQATYRVSAVDVDTDIKLEELKASISVLLRLPHPSSLIEAGVDESQGSLKRPGGAYNRTDCSEETSGCEECRKVKRQKLSEERGSLVQPNPVDDEDIWWLRKGLKYTESLRAEPPPKPAKQTSRSRQKSVRKTQSLAHLAAARIEGSQGASTSHVCESRIGCPHHRTGSDDTTRLMDDTRKLLSGDVVSIGKRLKQMRFVEKRTLIVWLISVVKQLIEQAERTTPKVGQYGRSMPAADDRSSTKWKLGEDDLSAILYMMDVCSEYVSATRFLLWLLPKIPNNPGSAIPSRNVMMLPRIAENNACDIGEAFLLSLIRSYENIIVAADLIPETLSAIMHRAATILASKGRLSGSPALIYVRHLLKKYNNVASVNEWEKSFKSTCDKRLSSEIESGRSLQGDFSFTLGVPNGVEDLDDYFRQKINGIRASRVDEAFQYLYSKDRKPYGTGTNKSPSIEKWDDGYQIAQQIVMGLIDCMRQTGGAAQEGDPSLVSSAIAAIVNNVGHAISKIPDLTAGSNHLNVPSPSGSLHVARSILHIHISCLCILKEALGERQSRVFEVALATEASSALMQAFAPGKASRGQFQMSPESHDFNASLPNETSNHPNKTVLGRAARITAAVSALVIGAILQGVASLDRMVTLFRLKEGLDLIQFARSMKSNVNGSARSMGILKVDNLIEVSLNWFRVLVGNCRTVSDGFILELLGEASIVAFCRMQRVLSLNLVFPPAYSIFAFVIWKPILDAGIGAREDFHQLHQLLSITMDDAIKHLPFREICLRDTHSLYNLIALDTLDSEFVSMLESIGSDSNLKAAALVPLRSRLFLDALIDCKISEPVIKVDGGNWISGQGDLKKQCAENVKKLMGKLVHVLDTLQPAKFHWQWVELRLLLNEQAVNEKMIENDISLTDAIRSLSPHPDKSMASENESNFVQIILTRLLVRPDAAPLFSEAVHLLGKSLEDSMLSQAKWLLSGAEVLYGKKSIRQKIMNIVADLKELSLKPQYWKPWGWCHANPMTTKGDKWKSEAAALEEGEVVEEGTDFNQFGKGYGLLDLERFIVNQQYLTDRALIELILPCVDQGSDELRNNFASEMIKQMSNIEQQINAVTRGVSKLTANPTHSIGSPANKSGSRKNAKSGSPGISRQPTGSADNVPPSPAALRTSMTLRLHFLLRLLPIICADREPSGRNMRYVLASVILRLLGSRVVYEDACHFVNNASNSSKRDVESFTETSAATLLRRENLFDCLLLVLHVLLSSNQPSWLKMKSESKSSEFTKDYAVFDCDVAESLQNDLDRMDLPESIRWRIQTAMPILIPSARCSISCQPPSVSPSALACLQPSNPVTLLNPSNSNTPQRNLFLSGRAAKTKPQTSQQDPDMEMDQWTLLEDGAGSGQPSPNSAGSSGGDQANLKASNLLKGAVRVRRTDLTYIGTVDEDS
Length2189
PositionKinase
OrganismHandroanthus impetiginosus
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Lamiales> Bignoniaceae> Crescentiina> Tabebuia alliance> Handroanthus.
Aromaticity0.07
Grand average of hydropathy-0.287
Instability index44.13
Isoelectric point8.55
Molecular weight243184.67
Publications
PubMed=29253216

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16374
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.99|      48|     167|      39|      94|       1
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   39-   94 (77.34/67.05)	SLNSRLGppdFHPPTPNCPEETLTR...EYVQHGYKETVdgleeAREISFSQVQAFDKS
  210-  260 (83.65/51.90)	SSNSSSG...YHDKPQLSRSEQWTRdliEYLQHLLDEFI.....ARNNSHSTSHMRDRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     393.22|     130|     384|     385|     529|       2
---------------------------------------------------------------------------
  385-  529 (203.94/188.76)	YEMLRYLILAVP.DTFVALDSFPLPTSVISHVVNDGSFL..........................SKMAEDARKVKYGQVDvagvhRDRNYEVQAESLSFQSV..VSSIQKRAETLsRAAKPNRPAHNVAKALQ...VLDQTLMH...GDIRDSYNllleNTWDGVCAERWGaevspCLH
  763-  927 (189.28/139.45)	YSQATYRVSAVDvDTDIKLEELKASISVLLRLPHPSSLIeagvdesqgslkrpggaynrtdcseeTSGCEECRKVKRQKLS.....EERGSLVQPNPVDDEDIwwLRKGLKYTESL.RAEPPPKPAKQTSRSRQksvRKTQSLAHlaaARIEGSQG....ASTSHVCESRIG.....CPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     372.75|     136|     384|    1657|    1801|       3
---------------------------------------------------------------------------
 1657- 1801 (212.37/169.98)	IENDISLTDairSLSPHPDKSMASE...NESNFVQII..LTRLLVRPDAAPLFSEAVHLLGKSleDSMLSQAKWLLSGaEVLYGKKSIRQKIMNIVADLKELsLKPQYWKpwGWCHANPM.TTKGDKWKSEAAALEEGEVVEEGTDFNQFG
 1825- 1875 (29.86/10.43)	IELILPCVD...QGSDELRNNFASEmikQMSNIEQQInaVTRGVSKLTANPTHS.................................................................................................
 2092- 2183 (130.52/82.28)	.....................................................SNPVTLLNPS..NSNTPQRNLFLSG.RAAKTKPQTSQQDPDMEMDQWTL.LEDGAGS..GQPSPNSAgSSGGDQANLKASNLLKGAVRVRRTDLTYIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.19|      23|     380|     705|     745|       4
---------------------------------------------------------------------------
  658-  680 (40.35/31.39)	RQLIVSGI....MDGNGSMADLEKQKR
  719-  745 (32.84/20.14)	RRLVLNGLsghgKSGSGSVSAVKKQKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     252.15|      97|     887|    1033|    1173|       8
---------------------------------------------------------------------------
   96-  141 (47.58/12.03)	..........................................................IIKCKEAIRKYHR..AINE......SRAQKRKAGQV.YGVPLSGTLLTKAGIfPD
 1060- 1171 (135.20/122.69)	RIAENNACDIGEAFLLSLIRSYEniiVAadLIPETLSAIMHRAATILASKGRLSGSPaLIYVRHLLKKYNNvaSVNEweksfkSTCDKRLSSEIeSGRSLQGDFSFTLGV.PN
 1298- 1349 (69.37/26.04)	HIHISCLCILKEALGERQSRVFE...VA..LATEASSALMQAFAPGKASRGQFQMSP........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.04|      10|     889|    1033|    1042|       9
---------------------------------------------------------------------------
 1033- 1042 (20.57/11.02)	RFLLWLLPKI
 1923- 1932 (19.47/10.04)	HFLLRLLPII
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16374 with Med12 domain of Kingdom Viridiplantae
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