<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16332

Description RNA polymerase II transcription mediator
SequenceMQRYHAGNCTSAVNNNAIGGIQARDTSRAESPAVPPNYSLNSRRSSPVTSYALRCDKEQLNSRLGPPDFHPQSPKCPEETLTREYVQFGYRDTVEGLEDAREISLTQIHAFKKPIIVKCKEAIRKYHRAINETRAQKRKADQVYGLPLSGTLLAKSGTFPELRPCGEDFRKKWVEGLSQPHKRLRSLADHVPHGYRRKSLFEVLIKNNVPLLRATWFIKVTYLNQVRPVSSNSSSGFHEKPQFSRSEQWTKDIIEYLKYLLDAFMARNTSYSTLQLHERASPMVYAGLGQQKGDSFSAVMDTEEPSLYTKWWYVVRIIHWHHAEGLIVPSLIIDWVLSQLQEKALLGVLQLLLPIIYGVVETVVLSQTYVRTLVGIAIRFIQEPSPGGSDLVDNSRRAYTTSAVVEMLRYLILAVPDTFVALDCFPLPSYLVSHVVNDGSFFSKMMEDARKIKEGHIEVAGVHRDKNHEVQAESLSFLSVVSSIQKRAETLSRAARPNQPGYSVAKALQVLDQALLHGDIGVAYKFLFENLCDGACAEHWIAEVSTSLHTSLQHIGSVKSSVLCSIFFICEWATCEFRDFRTVPPHGLKFTGRKDFSQIFIAIRLLELKMSNMPKLYSSRRSSKDVSDILESPGPLHDIIVCWIDQHEVQNGEGFKRLQLLIRELIQSGIFNPLAYVRQLIISGIMDWNGPMVDLEKQRRHYKLLKELPASYIHDTLQEAKIAEQPIVAEAMNVYSIERRLLLHGLLGQRKSNPNANSSAKKPKHQQSFGSGSGSPSSVERWYFQATSNLSVTDLDTDIKLDELKASISVLLKFPISSSSIGTGIDESHGNTKKRGGAYNGTDVSEETSECEECKRAKRQKLSEERSLFMQPLSADEEETWWVRKGQKYMESFRTEPPPKPAKQTSRGRQKSGRKTQSLAQLADARIESSQGASTSHVCESRMGCPHHRTGLDEISQSVDGTRKPPSADILLIGKLLKQMRFVQKRNVAVWLISVVKELIEEAEKLAAKVGQYGRSLPTTDDRSSMRWRLGEDELSAILYIMDFCDELVSATRFLLWLFPKLPSNPGSTIQSRNVLLLPRSTENHACGVGEAFLLSSMRRYENVIVAADLIPETLSATMRRAAAVLASNGRISGLPSLVFARHLLRKYGNIASVVQWEKTFNSSSDRRLSSELETGRSSEGDHGFSLGVPNGVENLDDYIRQKISGVRVSRVGLSMKEIVHRHVDEVFHYFYGKDRKPFGTGTNKSPSMEKWDDGYQIAQKIVMGLMDCMRQTGGAAQEGDPSLVSSAIAAIVNNAGQVIARIPDLTTSSNHLNVTPLSGSLHFARCILHIHITCLCILKEALGERQGRVFEVALATEASSALMQASGPGKAPRSQFQVSPESHDFNANLPNEASNHSSKSVLGRAARISAAVSAVVVGAILQGVASLERMVTLFRLNEGLDLIQFARSLKSNVNGNARSMGVLKVDSSIEVSVNWFRVLVGNCRTVSDGLLVELIGEASILALSRMQRMLSLNMVFPPAYSIFAFVVWRPILDASFGLREDFYQLYQSLTVAIGDAIKHLPLRDICLRDTYGLYDLIAADNLDSEFVSMLDFNGSDIASKAAALVPLRSRLFLDALIDCKMPQSVFKLDEKIRASNQGELKKQCGENVKKLIGKLVYVLDTLQPARFHWQWVELRLLLNEQAVNEKMENDVSVVEAIRSLSPNPDKSTASDNESNFIQIILTRLLVRPDAAPLFSEVVHLLGRSLEDSMLSQAKWLLRGPEVLYGKKSIRQKIVNIAAELKELSLKPLYSRPWGWCRSDVNRATNKGDRWKSEGSALEEGEVVEEGVEFNQSGKGSGLLDREGFLVSQHHVTERALIELILPCIDQGSDDLRYNFASEMIKQIGNIEQQINAVTRGFGKQAVTPSPATVSPANKGSNRKSGKTGSPGISRQSTGGAEPVPPPAPAALRASMTLRLQFLIRLLPVICADREPSGRNMRSTLASVILRLLGSRVVHEDAGHFVKPGFISSKRGVESLMEISDAGELLRKETMFDCLLLVLYVLLSCNQPSWLMLKSESKATESSKEYAAFDREMAESLQNDLDRMELPEMIRWRIQTAMPILFPSIRCSISCQPPSVSRDNIARLQPSNPVTTYYPNTSNPTQRNQRVKTKPQPLQQDLDTEIDQWTLLEDGTGSSQPSANSTGISSNDHSNLKAVHWLKGAVRVRRTDLTYIGAVDDDS
Length2219
PositionKinase
OrganismHandroanthus impetiginosus
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Lamiales> Bignoniaceae> Crescentiina> Tabebuia alliance> Handroanthus.
Aromaticity0.07
Grand average of hydropathy-0.273
Instability index47.98
Isoelectric point8.73
Molecular weight247221.65
Publications
PubMed=29253216

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16332
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     298.88|      99|     623|    1107|    1226|       1
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 1108- 1214 (144.31/139.82)	ADLiPEtlSATMRRAAAVLASNGRISGLPSLVFARHLLRKYGNIASVVQWEKtFNSSSD.....RRLSSELETGRSSEGdhgfSLGVPNGVENLDDYIRQKISGVRVSRVGL
 1388- 1491 (154.57/94.68)	ANL.PN..EASNHSSKSVLGRAARISAAVSAVVVGAILQGVASLERMVTLFR.LNEGLDliqfaRSLKSNVNGNARSMG....VLKVDSSIEVSVNWFRVLVGNCRTVSDGL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     392.26|     183|     306|     580|     782|       3
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  580-  659 (51.81/44.48)	......................................................................................................................................................................................................................................................FRT.VPPHGLKFT..GRKDFSQifiairllelKMSNMPKLYSSR.RSSK..DVSDILES.PG.PLHDiivCWIDqhEV.QNGEGFKRLQ
  660-  782 (156.85/90.60)	LLIRELIQSGIFNPLAYVRQLIISGIMDWNGPMVDLEKQRRHYKllKELPASYIHDTLQeAKIAEQPIVA..EAMN....VYSIERRLLLhgLLGQRKSNPNANSSAKK....PKHQQSFGSGSGSP...SSVERW.......................................................................................................................................................................................................
  893-  966 (34.57/10.93)	........................................................................................................................................yfqatsnlsvtdldtdikldelkasisvllkfpissssigtgideshgntkkrggayngtdvseetseceeckrakrqklseerslfmqplsadeeetwwvrkgqkymesFRTePPPKPAKQTsrGRQKSGR..........KTQSLAQLADARiESSQgaSTSHVCESrMGcPHHR...TGLD..EIsQSVDGTRKPP
  971- 1101 (149.04/73.06)	LLIGKLLKQMRFVQKRNVAVWLISVVKELIEEAEKLAAKVGQYG..RSLPTTDDRSSMR.WRLGEDELSAilYIMDfcdeLVSATRFLLW..LFPKLPSNPGSTIQSRNvlllPRSTENHACGVGEAfllSSMRRY.......................................................................................................................................................................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.27|      23|    1681|     226|     250|       5
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  226-  250 (40.18/25.18)	VRPVS..SNSSSGFHEKPQFSRseQWT
 1910- 1934 (37.09/17.72)	VSPANkgSNRKSGKTGSPGISR..QST
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.54|      25|    1170|     489|     530|       6
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  357-  381 (41.39/16.09)	YGVVETV.VLSQTYVRTLVGIAIRFI
  502-  527 (37.15/23.00)	YSVAKALqVLDQALLHGDIGVAYKFL
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     386.30|     124|    1482|      35|     171|       7
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   35-  171 (202.16/150.80)	PPNYSLNSRRS.SPV..TSYALRCDKEQLNSRL....GPPDFH.PQSPKCPEETltreyvqFGYRDTVEGLE.DAREISLTQIHAfkKPIIVKCKEAIRKYHRAINETRAQKRKADQVYGLPLSgtllAKSGTFPEL.RPCGEDFRK
 1518- 1651 (184.13/112.40)	PPAYSIFAFVVwRPIldASFGLREDFYQLYQSLtvaiGDAIKHlPLRDICLRDT.......YGLYDLIAADNlDSEFVSMLDFNG..SDIASKAAALVPLRSRLFLDALIDCKMPQSVFKLDEK....IRASNQGELkKQCGENVKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.46|      22|    1680|     537|     558|       8
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  537-  558 (38.89/26.11)	AEHWIAEVSTSLHTSLQHIGSV
 2194- 2215 (38.57/25.82)	AVHWLKGAVRVRRTDLTYIGAV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16332 with Med12 domain of Kingdom Viridiplantae
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