<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16322

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDTAVNGHLTNGTAHLPLQNGKADAHEPSLEQLESELPLVMDGMLPLGELVSRLAQAIYAELVEMAETMPSMSDAARKRYVADWVIRMKRQVVKLYAIAKWSRDAAVVQKAMNITAFLMDQNQQFEDAIMALKYGRDTLDPARLRNHDLLTSLDVLTTGTYRRLPSCIKELIVPPTPLTDDEVSRTFTDIEDAMRFRLRMSEIVPWEMSQYRIGNGRVFFTAPKLFELSLCLQGAGGNAGWFFVNVTFLFTVGGDQTGMQEFPRTPTGVLKRNITDEADARLAFYLPPNEPPPPGMEPPPRPQLPEGMVDAPLVRVFNFLQMMSLSYQLEILWYQAERMRSLGWAEYMNVEMANNRQTMVVHYWVRKPPPPNQKRPAQQKPLPTLGGKLIISIVQVKEKTGRKAMRSPRARVLAELQSRSKLEGTVPSDEVESMRFEVRWEPEAGALGVAPAREEMLMVAEELQIDPEELDLERLLRKVIRRHTEGVMKFFQVQLQRGISTRGVFSRPGEVSFVSNEGAPSLRVHLCTDEVVIVTVDPRTGRLTLRDTGDLAAAGRGPRFSAITQRLHDTPFMLPQALVVVRNATITDLAEQKVQYLGLQSFRTRNFSVDEIKKFGQDAQGQIYIQLGNFSTHYLVLVIADQDFRYALISVKEVEQSMNHDLVMEDIGWLNIRRIYGDEIAVESGTGLDPVTGQKRKRDDGVGRAGPSGEQYPTSFRLETNVLRELYAYCCARVAYTKVEQQFKLRGIPYTHVNSSASAVPEFGNVQSSLARTIPALCVQSSDILSGAPAAEAAMPNIRVIPLNWWSNDAAKVVTCVKLKYVQQPIGKRASGSTVIRPSKQIIYDTREAIVSFLSDNVDKCVDEFLEEWARVSKMVVIAREVAQMSTKYLWTDIRLISFDLQTVEFAYAENYTVSLTCTDQLATNRSSYHLRFSRVPSDDPMQVDGELDALHNPHEDAELYLCNLLGHGKLSTALHRLVSLLRETLPIVAELEDIRVHAARQGHLVDSFAKSAGWFRVLYPDLRHALDFRLMTGARVIVVDGSHTLFDEPPTGDPRIARRPGGPSRSTSLANTGALQAIPDFRALVAEAINDAVAQGVKGQFAPIDIGVICDIAAVRVVGRRLYERVFARLAQQAPRPPHP
Length1141
PositionTail
OrganismGanoderma sinense ZZ0214-1
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Polyporaceae> Ganoderma.
Aromaticity0.08
Grand average of hydropathy-0.214
Instability index42.58
Isoelectric point6.54
Molecular weight127816.16
Publications
PubMed=26046933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16322
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.83|      21|      75|     285|     305|       1
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  285-  305 (46.52/22.53)	YLPPNEPPPPGMEPPPRPQLP
  363-  383 (41.30/19.23)	YWVRKPPPPNQKRPAQQKPLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     477.17|     155|     508|     413|     595|       3
---------------------------------------------------------------------------
  426-  595 (233.53/206.81)	VPSDEvesmrfEVRWEPEAGALGvAPAREEMLMVAEELQIDPEELDLERLLrKVIRRHTEGVMKF..FQVQLQRGISTRGVFSR.PGEVSFVSNEGAPSLRVHLCTDEVVIVtVDPRTGRLTLRDTGDLAAAGR..GPRFS...AITQRLHDTP.FmlpQALVVvrnATITDLAEQKVQ
  936- 1099 (243.64/152.60)	VPSDD......PMQVDGELDALH.NPHEDAELYLCNLLGHGKLSTALHRLV.SLLRETLPIVAELedIRVHAARQGHLVDSFAKsAGWFRVLYPDLRHALDFRLMTGARVIV.VDGSHTLFDEPPTGDPRIARRpgGPSRStslANTGALQAIPdF...RALVA...EAINDAVAQGVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.90|      13|      14|      72|      84|       4
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   72-   84 (24.39/18.68)	MSDAARKRY.VADW
   88-  101 (19.51/13.33)	MKRQVVKLYaIAKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     203.40|      67|     531|     122|     198|       6
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  122-  198 (100.69/88.80)	NQQFEDAIMALKYGRDTLdparlrNHDLLtsLDVLTTGTYRRLPSciKELIVPP....TPLT......DDEVSRTFTDIED.AMRFRL
  641-  718 (102.71/65.03)	DQDFRYALISVKEVEQSM......NHDLV..MEDIGWLNIRRIYG..DEIAVESgtglDPVTgqkrkrDDGVGRAGPSGEQyPTSFRL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16322 with Med14 domain of Kingdom Fungi
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