<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16316
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MLSLHAKISDLVAHALAFIEDYECETVGDPQSAVSHLGDVVLFIETTIARFNLVSLSFKVGERTVSLEFMRTSGVHMRPSELKGEEIPAFTSWIKALFDPGSEGIEDTILRATRPKTLLKIAPALFAFAILQTMERKMDKEVLSNGLSYFLGPLLNWTLAGVVRSLLTDIQRRGYNAPVHLDVLKTLLTSLSCPPAVLTLSAPSVLRLFPHPFPQHSRRILQAFDPKPIRQAARQALGLPAEAVPIEMEPSAQWSHQVRQLVSNALAAARSGRAPALDVDRCLLLCPPTKFLGALWAHLRHAATMADMEAPRRLATFVLTIPRTPRSPPLLPIFLHLVLPSLVASADRMSAADHATTVEFLVAVISSALTAALHLEWALLTTCGEERFVLGQSVTSMARRLAGDLKKRGTGTTAGMVLQRLTAMQPFVANFPTFTAEV |
Length | 438 |
Position | Tail |
Organism | Ganoderma sinense ZZ0214-1 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes>
Polyporales> Polyporaceae> Ganoderma.
|
Aromaticity | 0.07 |
Grand average of hydropathy | 0.227 |
Instability index | 47.77 |
Isoelectric point | 9.01 |
Molecular weight | 47878.40 |
Publications | PubMed=26046933
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP16316
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 125.55| 39| 95| 151| 195| 1
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151- 195 (56.86/51.10) LGPLLNWTLAgvVRSLLTD..IQRRGYNAPVhLDVLKTLLTslsCPP
248- 288 (68.69/41.56) MEPSAQWSHQ..VRQLVSNalAAARSGRAPA.LDVDRCLLL...CPP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 78.98| 22| 123| 79| 100| 2
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79- 100 (40.72/24.86) PSELK..GEEIPAFTSWIKALFDP
203- 226 (38.26/22.95) PSVLRlfPHPFPQHSRRILQAFDP
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|