Description | Putative mediator of RNA polymerase II transcription subunit 21 isoform X1 |
Sequence | MSDRVTQLQDAVNQMAEHFCNSIGVLQQNATPSKFQPPEKQGTADAPAVQDDFTQLFAQLIARTAKDIDVLIESLPSEELTTELQNTSLKKLEQENKEAAQRLSDLVKRGDTLLLRIQEALSEIAEAQLRTKSSITSKSSNSKLPDNGT |
Length | 149 |
Position | Middle |
Organism | Stichopus japonicus (Sea cucumber) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Echinodermata> Eleutherozoa> Echinozoa> Holothuroidea> Aspidochirotacea> Aspidochirotida> Stichopodidae> Apostichopus. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.579 |
Instability index | 50.09 |
Isoelectric point | 4.82 |
Molecular weight | 16411.16 |
Publications | PubMed=29023486 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | |
GO - Biological Process |
Binary Interactions |
Repeats | >MDP16306 No repeats found |
MoRF Sequence | Start | Stop |
1) DFTQLFAQLIAR 2) SLKKLEQENKE | 52 88 | 63 98 |
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