<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16299

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMDRSTRTTQLTNGYVIGSAHDENVHLFNVLELITLLSILLLSIIANCSLLIAILRSRRLRRNNHNLLVLNLIVFDLFSTFGSMTVSLIDLIYTGFLLRHPLLCRIHGTIALLGCFGNYATVALISMFRCFTVLADGRIAVKRYHVVMIMASGCIVSVAMVFPPASGIASKFVYTPGTHHCSPSWQDSCFYYTTSLALGYCVTVPSMIISYVLITLKVKKSSDRVRKLNTGDLNALQTRAQSAKDLPTQSSTELGVINDCAISVGTNTRVDSIGCTDTDQEQRGTDQRITDNDDGQTMPGGVSELRLTKLRKKHLHNIAMRNRLHLQPQPKEALDTALENLSKRILDIKKALTTLLFKLETEPDTIQWPSLLDSFALLSGHLNVLTNIYFKNQGSNLENVVLRPLNLSKDPDEQLDNLTERRVQSFSNEVVPNYLRTKPEPATEEKERGKQRDAGQVSQELATVSAK
Length466
PositionHead
OrganismStichopus japonicus (Sea cucumber)
KingdomMetazoa
LineageEukaryota> Metazoa> Echinodermata> Eleutherozoa> Echinozoa> Holothuroidea> Aspidochirotacea> Aspidochirotida> Stichopodidae> Apostichopus.
Aromaticity0.06
Grand average of hydropathy-0.050
Instability index39.40
Isoelectric point8.83
Molecular weight51875.26
Publications
PubMed=29023486

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
G protein-coupled receptor activity	GO:0004930	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16299
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.64|      47|      79|     314|     364|       1
---------------------------------------------------------------------------
  314-  364 (68.18/55.68)	LHNIAMRNrLHLQPQPKEALDTALEnlsKRILDIKKALTTLLFKLETEPDT
  396-  442 (79.46/51.80)	LENVVLRP.LNLSKDPDEQLDNLTE...RRVQSFSNEVVPNYLRTKPEPAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.42|      50|      54|      32|      85|       3
---------------------------------------------------------------------------
   32-   85 (76.47/56.17)	LITLL.SILLLsiiaNCSLLIAILRSRRLRRNNHNLLVLNLI.VFDLFSTF..GSMTV
   87-  140 (74.95/46.52)	LIDLIyTGFLL....RHPLLCRIHGTIALLGCFGNYATVALIsMFRCFTVLadGRIAV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16299 with Med8 domain of Kingdom Metazoa
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