<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16292

Description Putative cyclin-dependent kinase 8
SequenceMDYEFKNETNSIRQKVEDLFDFEGCKVGRGTYGHVYKATTKKTPKQEYALKQIEGTGISMSACREIALLRELKHRNVICLRRVFLSHGDRKVWLLFDFAEHDLWHIIKYHRNNKASKKGPTSVPITMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPDRGRVKIADMGFARLFNSPLTPLPTWILWLLHSGTELLNYYLVLGITPRRSLLEAILFFLILYVDIWAIGCIFAELLTSEPIFHCRQEDIKTNTPYHRDQLDRIFMVMGFPQDKDWEDIKKMPEHGTLLKDFKKANYAHYSLIRYMDKHKVKADSKAFQLLSKLLIVDPMKRITSELAMEDPFFKEEPLPTLDVFDGKTIQYPKREFLTDEDNEEKSVSKQKTSSSGHSSNAKRIRSSGQSGGMMQQDYQSSQQKHMMSGYQGGSGQGNHNQGQGNRMYTSGSGSHTGHSKMTHGSQHHQSHSQHHQRQHQQHPHRY
Length481
PositionKinase
OrganismStichopus japonicus (Sea cucumber)
KingdomMetazoa
LineageEukaryota> Metazoa> Echinodermata> Eleutherozoa> Echinozoa> Holothuroidea> Aspidochirotacea> Aspidochirotida> Stichopodidae> Apostichopus.
Aromaticity0.10
Grand average of hydropathy-0.631
Instability index45.15
Isoelectric point9.25
Molecular weight55622.94
Publications
PubMed=29023486

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16292
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.37|      45|      97|     236|     282|       2
---------------------------------------------------------------------------
  236-  282 (74.66/61.05)	IFAELLTSEPIFHCRQEdIKTNTPYHRDQ....LDrIF..MVMGFPQ.....DKDWED
  324-  379 (59.72/39.53)	LLSKLLIVDPMKRITSE.LAMEDPFFKEEplptLD.VFdgKTIQYPKrefltDEDNEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.28|      31|      79|      14|      44|       3
---------------------------------------------------------------------------
   14-   44 (56.04/29.23)	QKVEDLFDFEGCKVGRGTYGHVYKATTKKTP
   90-  120 (58.24/30.61)	RKVWLLFDFAEHDLWHIIKYHRNNKASKKGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.08|      16|      18|     402|     417|       6
---------------------------------------------------------------------------
  402-  417 (30.61/16.65)	SGQSGGMMQQDYQSSQ
  423-  438 (31.47/17.30)	SGYQGGSGQGNHNQGQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16292 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PKREFLTDEDNEEKSVSKQKTSSSGHSSNAKRIRSSGQSGGMMQQDYQSSQQKHMMSGYQGGSGQGNHNQGQGNRMYTSGSGSHTGHSKMTHGSQHHQSHSQHHQRQHQQHPHRY
367
481










Molecular Recognition Features






MoRF SequenceStartStop




1) QDYQSSQQKHMMSGY
411
425