<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16287

Description Putative mediator of RNA polymerase II transcription subunit 13-like
SequenceMCSLTRRTIPMVPSVEMDLPASNQPSGLTPSAGIMASPAMYPGSQEPRSAANPDPSPAASEASSFRNLNSIEQPSSAAICPSLTASTRFLALSDSQLNIFKDCNFDSAVICACNMDIKGSDLADVGVYFTQCNCGFSAVMNRRYAVGSGLFSEDESEITGQRTDAPLWAYHRDNPYLTEIFNQKQLLPRLQSFVKDGVEELHRTSKIVLKLIQDQCHSPYSSLQSLLSVIRERTEYQYGQIARSNLEYLDACDACVSAIDDGRHLSESAGRGAWDPQYLRHRCLHTWAYNPGYVRIPLSSQDIVQVLRSLQPLLHDAIQKKRTKRLWERPYAVQGPLTWQVFFNIAIQDASESPEPLPVPPLLVGYEKDWMSSSPYAVLYWEKLLLEPFSSSRDIAYIALVPDQEFICKRAKTFSRNSLLCRGRHVPMAKSMRNGILRIGQKYASKVESEQVDSWFSDINELPEAAKIKVFAQVCKAYVAPYLMKDPPDASMFTSQPAKMDRAYAAHSTVPVSTSAMTGYPAGGVPNGSAEFAAKGAMAAPTSKGVTTSAHADFVQPPGVVIYVVDPFTCKEDEHPDYAGITTLGLLRCFAEIVECLPENLVKTLPSRLFLFTKCSRWPIAAQVNGKLSQLKSLAFSVFSQCHQTVNPSLPGRSLTGVRPAAELDKVIKAKESRSIHPNQVYSPPYILAPLKDKQTELGESFGDLREPAGSSSVPTACRTTKDFSSQPAQTTRANSTRLPSLTSTYQTVKGERRFQSTTEPC
Length762
PositionMiddle
OrganismStichopus japonicus (Sea cucumber)
KingdomMetazoa
LineageEukaryota> Metazoa> Echinodermata> Eleutherozoa> Echinozoa> Holothuroidea> Aspidochirotacea> Aspidochirotida> Stichopodidae> Apostichopus.
Aromaticity0.08
Grand average of hydropathy-0.287
Instability index57.32
Isoelectric point7.95
Molecular weight83988.57
Publications
PubMed=29023486

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16287
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.99|      33|      33|     503|     535|       1
---------------------------------------------------------------------------
  503-  535 (58.97/38.52)	AYAAHSTVPVSTSAMTGY..PAGGVPNGSAEFAAK
  537-  571 (56.02/36.20)	AMAAPTSKGVTTSAHADFvqPPGVVIYVVDPFTCK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.35|      26|      28|      55|      80|       2
---------------------------------------------------------------------------
   25-   54 (36.02/19.00)	PSgltPSAGI...MASPAMYPGSQEPR..SAAnPD
   55-   80 (45.69/26.12)	PS...PAASE...ASSFRNLNSIEQPS..SAA.IC
   81-  111 (33.65/17.27)	PS...LTASTrflALSDSQLNIFKDCNfdSAV.IC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.86|      35|      42|     291|     332|       4
---------------------------------------------------------------------------
  297-  332 (58.35/46.97)	PLSSQ...DI.VQ.VLRSLQPLLHDAIQKKRTKRlW..ERPYA
  336-  377 (48.51/22.50)	PLTWQvffNIaIQdASESPEPLPVPPLLVGYEKD.WmsSSPYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     201.93|      74|     417|     153|     229|       5
---------------------------------------------------------------------------
  153-  195 (60.37/28.49)	...........................................................................................................................................................................................................................................................................................................................................................................................EDE.SEITGQ..RTDAPLWAYHRDNPYLTEIFNQKQLLP.RLQSFVK
  196-  229 (22.27/15.03)	DGveELHRTSKIVLKLIqDQCH...SPYSSLQSLLSV.....................................................................................................................................................................................................................................................................................................................................................................................................
  572-  614 (41.28/17.20)	.....................................irerteyqygqiarsnleyldacdacvsaiddgrhlsesagrgawdpqylrhrclhtwaynpgyvriplssqdivqvlrslqpllhdaiqkkrtkrlwerpyavqgpltwqvffniaiqdasespeplpvppllvgyekdwmssspyavlyweklllepfsssrdiayialvpdqefickraktfsrnsllcrgrhvpmaksmrngilrigqkyaskveseqvdswfsdinelpeaakikvfaqvckayvapylmkdppdasmftsqpakmdrayaahstvpvstsamtgypaggvpngsaefaakgamaaptskgvttsahadfvqppgvviyvvdpftckEDEhPDYAGI..TTLGLLRCFAEIVECLPE..NLVKTLPsRLFLFTK
  625-  695 (78.01/39.63)	NG..KLSQLKSLAFSVF.SQCHqtvNPSLPGRSLTGV..................................................................................................................................................................................................................................................................................................................................................rpaaELD.KVIKAKesRSIHPNQVY..SPPYILAPLKDKQ...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.49|      10|     230|     493|     502|       6
---------------------------------------------------------------------------
  493-  502 (20.06/13.13)	FTSQPAKMDR
  724-  733 (19.44/12.47)	FSSQPAQTTR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16287 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGSSSVPTACRTTKDFSSQPAQTTRANSTRLPSLTSTYQTVKGERRFQSTTEPC
2) PSVEMDLPASNQPSGLTPSAGIMASPAMYPGSQEPRSAANPDPSPAASEASSFR
709
13
762
66










Molecular Recognition Features






MoRF SequenceStartStop




NANANA