<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16283

Description Putative mediator of RNA polymerase II transcription subunit 14
SequenceMAESHGKRSLQDADYQHKRRRSTPSVRCEKDLAHIIALCDGRIPFIKLTEELRKKGIPHQGIQTDSNCTGLVLKLIRVPNCQSVSKETNDALAAALLSCSFRLMQRKSQGLWKVELIFCKCPVVSSVPKEQGPLQHVYLHYEMNPAHSVLDQFFQDWESIANLYELVLGLPCALPYLTLAPTSRSSWLQEHSLPYSIMVDIVTVKWDFKNKEFKLMFGVIGPKTATNCHSLLRHCMQQELNVHKALPVLLKVLCYTQSPLQAICKLPIMSIVKSSTNGMLSPAFSFVLLPQSSSHFRLMYGTAYYLEIHCKGKNAITIKDGAYSHFNIRTNIDGYISIPGLKAFLDLHVDDTASNRRHAIAEEDNPASPMDTLPPQTDPFMAGPPQQHPAAASPMFNQKMGTQGATGGLLTLAVTQPPLLLPILQFSLKLLISTDESCTLSNKIDFHHFKQYSMSPGASAYPLASPPNIIPSPSGVMRGGAPSPALATGSPHHVPSPSSSFIHTPPPNIQLSSPGQFISPPRIPRHSRTFPFRSAAATLPTLLSHDALHKLCTPSMIQGLSTNMCSPMERFLGAALMKKQIQKHLQNQDASLTNQLQVPATTEMGSIQFYSESLHYKISMHPATMQYLQLSVRAVEDKEQYWTQDELRILEKYFETKVACPPFKNHDLVPSAPDGIHDDLEGLYQDSAPGAPARPEYEMAARMIKLTCINPAPPPGQEPLFETVGIVYDKNANLTSAVNLVKPRPPNFTTIENHLKNWNEYNMNKQDCSLFPAIRSLMTNLQLKI
Length785
PositionTail
OrganismStichopus japonicus (Sea cucumber)
KingdomMetazoa
LineageEukaryota> Metazoa> Echinodermata> Eleutherozoa> Echinozoa> Holothuroidea> Aspidochirotacea> Aspidochirotida> Stichopodidae> Apostichopus.
Aromaticity0.07
Grand average of hydropathy-0.235
Instability index58.50
Isoelectric point8.61
Molecular weight87246.77
Publications
PubMed=29023486

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16283
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.07|      17|      17|     231|     247|       1
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  231-  247 (31.97/20.10)	LLR.HCM.QQELNVHKALP
  249-  267 (23.10/12.45)	LLKvLCYtQSPLQAICKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.86|      21|      22|     454|     474|       2
---------------------------------------------------------------------------
  454-  474 (41.90/20.39)	MSPGASAYPLA.SPPNIIPSPS
  477-  498 (36.96/17.07)	MRGGAPSPALAtGSPHHVPSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.99|      15|      19|      96|     110|       6
---------------------------------------------------------------------------
   96-  110 (26.92/14.80)	LLSCSFRLMQR..KSQG
  116-  132 (23.07/11.76)	LIFCKCPVVSSvpKEQG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.96|      37|      40|     583|     622|      11
---------------------------------------------------------------------------
  583-  622 (57.40/54.58)	KHLQNQDASLTNQLQVPATTEMGSIQFYSESlhyKISMHP
  626-  662 (63.56/49.45)	QYLQLSVRAVEDKEQYWTQDELRILEKYFET...KVACPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16283 with Med14 domain of Kingdom Metazoa
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