<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16283

Description Putative mediator of RNA polymerase II transcription subunit 14
SequenceMAESHGKRSLQDADYQHKRRRSTPSVRCEKDLAHIIALCDGRIPFIKLTEELRKKGIPHQGIQTDSNCTGLVLKLIRVPNCQSVSKETNDALAAALLSCSFRLMQRKSQGLWKVELIFCKCPVVSSVPKEQGPLQHVYLHYEMNPAHSVLDQFFQDWESIANLYELVLGLPCALPYLTLAPTSRSSWLQEHSLPYSIMVDIVTVKWDFKNKEFKLMFGVIGPKTATNCHSLLRHCMQQELNVHKALPVLLKVLCYTQSPLQAICKLPIMSIVKSSTNGMLSPAFSFVLLPQSSSHFRLMYGTAYYLEIHCKGKNAITIKDGAYSHFNIRTNIDGYISIPGLKAFLDLHVDDTASNRRHAIAEEDNPASPMDTLPPQTDPFMAGPPQQHPAAASPMFNQKMGTQGATGGLLTLAVTQPPLLLPILQFSLKLLISTDESCTLSNKIDFHHFKQYSMSPGASAYPLASPPNIIPSPSGVMRGGAPSPALATGSPHHVPSPSSSFIHTPPPNIQLSSPGQFISPPRIPRHSRTFPFRSAAATLPTLLSHDALHKLCTPSMIQGLSTNMCSPMERFLGAALMKKQIQKHLQNQDASLTNQLQVPATTEMGSIQFYSESLHYKISMHPATMQYLQLSVRAVEDKEQYWTQDELRILEKYFETKVACPPFKNHDLVPSAPDGIHDDLEGLYQDSAPGAPARPEYEMAARMIKLTCINPAPPPGQEPLFETVGIVYDKNANLTSAVNLVKPRPPNFTTIENHLKNWNEYNMNKQDCSLFPAIRSLMTNLQLKI
Length785
PositionTail
OrganismStichopus japonicus (Sea cucumber)
KingdomMetazoa
LineageEukaryota> Metazoa> Echinodermata> Eleutherozoa> Echinozoa> Holothuroidea> Aspidochirotacea> Aspidochirotida> Stichopodidae> Apostichopus.
Aromaticity0.07
Grand average of hydropathy-0.235
Instability index58.50
Isoelectric point8.61
Molecular weight87246.77
Publications
PubMed=29023486

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16283
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.07|      17|      17|     231|     247|       1
---------------------------------------------------------------------------
  231-  247 (31.97/20.10)	LLR.HCM.QQELNVHKALP
  249-  267 (23.10/12.45)	LLKvLCYtQSPLQAICKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.86|      21|      22|     454|     474|       2
---------------------------------------------------------------------------
  454-  474 (41.90/20.39)	MSPGASAYPLA.SPPNIIPSPS
  477-  498 (36.96/17.07)	MRGGAPSPALAtGSPHHVPSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.99|      15|      19|      96|     110|       6
---------------------------------------------------------------------------
   96-  110 (26.92/14.80)	LLSCSFRLMQR..KSQG
  116-  132 (23.07/11.76)	LIFCKCPVVSSvpKEQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.96|      37|      40|     583|     622|      11
---------------------------------------------------------------------------
  583-  622 (57.40/54.58)	KHLQNQDASLTNQLQVPATTEMGSIQFYSESlhyKISMHP
  626-  662 (63.56/49.45)	QYLQLSVRAVEDKEQYWTQDELRILEKYFET...KVACPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16283 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NRRHAIAEEDNPASPMDTLPPQTDPFMAGPPQQHPAAASPMFNQK
2) PSPSGVMRGGAPSPALATGSPHHVPSPSSSFIHTPP
355
471
399
506










Molecular Recognition Features






MoRF SequenceStartStop




NANANA