<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16276

Description Putative mediator of RNA polymerase II transcription subunit 25-like isoform X3
SequenceMQRDVQDKQQVAGTIAGQVQPNQTMVQQQQAQQQLQHQQQQQQQHQQQQMSVLPALQQQQQAVRLPQHSNKQHAGIQHVHQAIAQQPQQLQSVMQPQQIPNIQQPQLSLAQLPGKKGLTKEGFLKMMQALPPEARKKFIEDLKVRKNQQQQQQVTSQAAGLVNSQTAASSSAVDLIQPNITIAKPQSSQNIGAATATVQGIPTSTTAGLAPMSAVAAARDVVRIAGVTATQDYQIRADKGSTPNNRNNPLLSNHLQQSGMPQQQQTSLQQQQQQQQASLQQQQQTTLQQQQNVNLQQQQQNAMQQQPGMPQQQANLQQDQLLNQQATMPSVSNMVFQPDQAGNVMSQTIVQQNNPPLVAMNPVNRAGVARPLKILWNGVLEWHERTKTSTMTQDQRIQHCINCSVSADPDTNINCDSWPKKLTMQVIPLKFLQSMNNLVKNAHIVNFDIPDQGANAEARRYLQRVLHSQFAGCIHLSSEVQSDTSIRVLLLWYIKASDQFKGRIPKDQAGFINNFRELIKKHQQEQQQKQLQQQQQQALIGARPQMQVPGMIQRPANMTQVMGPRNPIPPVAASNGQVLSQKDLQEFVKRLQQQKQQHQQQQQQQQQQQVQQQQSNQQLLQQAQQMSQVGIRPQGMVGQQQQVQVPTQTQQLPSNNAQLKNLLLNQAQAQSQGGQLQWNQPQQLGQQQQQLGQQQQLGQQQQQQLGQQQQQQNLLLQPQQLQQAAVAMGQQQRMPQRTMSQVMQQGGGFAQGITVQVGAWGPKGHSSTGHEPPRDARHGVFGFSRVVTQQPNSAILLRETNYRTFPLKGFKTWNQFPRPNRASRIRNWKDSQSVCSNHLHSSCCVYDVCRQRPLFHKPF
Length859
PositionUnknown
OrganismStichopus japonicus (Sea cucumber)
KingdomMetazoa
LineageEukaryota> Metazoa> Echinodermata> Eleutherozoa> Echinozoa> Holothuroidea> Aspidochirotacea> Aspidochirotida> Stichopodidae> Apostichopus.
Aromaticity0.04
Grand average of hydropathy-0.868
Instability index67.57
Isoelectric point10.32
Molecular weight96723.80
Publications
PubMed=29023486

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16276
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     874.09|     219|     232|      20|     251|       2
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   20-  180 (230.40/51.42)	.....................................................................................................QPNQTMV...QQQQ..AQQQ..LQHQQQ...QQQQH...QQQQ...MSVLPALQQ.QQQAV......RLPQHSNKQ................HAGIQHVHQAIAQQPQQ..LQSVMQPQQIPN.IQQ..PQLS.LAQLP.GKKGLTKEGFLKMM..QALPPEARKKfieDLKVRKNQQQQQ....QVTSQAAGLVNSQtaasSSAVDLIQPNI
  181-  427 (297.46/68.00)	TIAKPQSSQNI..............GA...ATATVQGIPTSTTAGLAPMSAVAAARDVVRIAGVtatqdYQIRAD...KGSTPNNRNNpLLsnhlqqsgmpQQQQTSL...QQQQ..QQQQasLQQQQQttlQQQQNvnlQQQQqnaMQQQPGMPQ.QQANL......QQDQLLNQQ.................ATMPSVSNMVF.QPDQ..AGNVM.SQTI...VQQnnPPL..VAMNPvNRAGVARP..LKILwnGVLEWHERTK...TSTMTQDQRIQHcincSVSADPDTNINCD....SWPKKLTMQVI
  428-  588 (193.12/37.53)	PLKFLQSMNNLvknahivnfdipdqGAnaeARRYLQRVLHSQFAGCIHLSSEVQSDTSIRVLLL.....WYIKASdqfKGRIPKDQAG.FI..........NNFRELIkkhQQEQ..QQKQ..LQQQQQ...QALIG...ARPQ...M........................................................................QVPGmIQR..PA.N.MTQVM.GPR.............NPIPPVAASN.........GQVLSQ....K....................DL.QEFV
  680-  836 (153.11/26.93)	.....................................................................................................QPQQLGQ...QQQQlgQQQQ..LGQQQQ...QQLGQ...QQQQ...QNLLLQPQQlQQAAVamgqqqRMPQRTMSQvmqqgggfaqgitvqvGAWGPKGHSSTGHEPPRdaRHGVFGFSRVVT..QQ..PNSAiLLRET.NYRTFPLKGF.KTW..NQFPRPNRAS.....RIR.NWKDSQ....SVCS........................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.30|      25|      41|     606|     630|       3
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  606-  630 (47.47/12.77)	QQQQVQQQQSNQQL...........LQQAQQMSQVG
  639-  674 (38.83/ 8.98)	QQQQVQVPTQTQQLpsnnaqlknllLNQAQAQSQGG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16276 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ARKKFIEDLKVRKNQQQQQQVTSQAAGLVN
2) ARPQMQVPGMIQRPANMTQVMGPRNPIPPVAASNG
3) DYQIRADKGSTPNNRNNPLLSNHLQQSGMPQQQQTSLQQQQQQQQASLQQQQQTTLQQQQNVNLQQQQQNAMQQQPGMPQQQANLQQDQLLNQQATMPSVSNMVFQPD
4) MQRDVQDKQQVAGTIAGQVQPNQTMVQQQQAQQQLQHQQQQQQQHQQQQMSVL
5) QQPQQLQSVMQPQQIPNIQQPQLSLAQLPGK
6) TVQVGAWGPKGHSSTGHEPPRDARHGVFGF
134
542
232
1
85
754
163
576
339
53
115
783










Molecular Recognition Features






MoRF SequenceStartStop




NANANA