<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16266

Description Putative mediator of RNA polymerase II transcription subunit 25-like
SequenceMQCPGKFSSSERNVNMSVISPRKLYELQQLYDKACGELQVLTTKEYALDQRHLILLRGYELQERSPAVELKEVKQDLLSPRKQPNNLVSMSAASSVAVASTSMNFTPSNVNTLLTAQSILSHKGQQQQQPIPTQAAVTINMKPKMSVASMQRDVQDKQQVAGSIAGQVQPNQTMVQQQAQQQLQHQQQQQQQHQQQQMSVLPALQQQQQAVRLPQQQQQQHAGIQHVHQAIAQQPQQLQSVMQPQQIPNIQQPQLSLAQLPGKKGLTKEGFLKMMQALPPEARKKFIEDLKVRKNQQQQQQVTSQAAGLVNSQTAASSSAVDLIQPNITIAKPQSSQNIGAATATVQGIPTSTTAGLAPMSAVAAARDVVRIAGVTVSNSRLPNQGGQGFNPQQPNNPLLSNHLQQSGMPQQQQTSLQQQQQQQQASLQQQQQTTLQQQQNVNLQQQQQNAMQQQPGMPQQQANLQQDQLLNQQATMPSVSNMVFQPDQAGNVMSQTIVQQNNPPLVAMNPVNRAGVARPLKILWNGVLEWHERTKTSTMTQDQRIQHCINCSVSADPIPTSTATVGQRNLPCRSFHLNFWVLTLRHGDTSSGFFHSQFAGCIHLSSEVQSDTSIRVLLLWYIKASDQFKGRIPKDQAGFINNFRELIKKHQQEQQQKQLQQQQQQALIGARPQMQVPGMIQRPANMTQVMGPRNPIPPVAASNGQVLSQKDLQEFVKRLQQQKQQQHQQQQQQQQQQQVQQQQSNQQLLQQAQQMSQVGIRPQGMVGQQQQQQVPTQTQQLPSNNAQLKNLLLNQAQAQSQGGQLQWNQPQQLGQQQQLGQQQQLGQQQQQLGQQQQQQNLLLQPQQLQQAAVAMGQQQRMPQRTMSQVMQQGGGFAQGITVQGGSMGGQRAILQQGMNPQGMQGMGKPMPRQQQQQQQQQQQQQGGKGGLRDDLSLMDLLQP
Length944
PositionUnknown
OrganismStichopus japonicus (Sea cucumber)
KingdomMetazoa
LineageEukaryota> Metazoa> Echinodermata> Eleutherozoa> Echinozoa> Holothuroidea> Aspidochirotacea> Aspidochirotida> Stichopodidae> Apostichopus.
Aromaticity0.03
Grand average of hydropathy-0.817
Instability index73.73
Isoelectric point10.15
Molecular weight105244.48
Publications
PubMed=29023486

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16266
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     174.84|      27|      27|     167|     193|       1
---------------------------------------------------------------------------
  167-  193 (52.45/11.12)	QV.....QPNQTMVQQQAQQQLQHQQQQQQQH
  397-  426 (40.54/ 6.18)	NPllsnhLQQSGMPQQQQTS.L.QQQQQQQQA
  427-  450 (40.17/ 6.03)	SL.....QQQQTTLQQQQNVNL....QQQQQN
  828-  852 (41.68/ 6.65)	QQ.....Q..QQLGQQQQQQNLLLQPQQLQQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     421.22|     146|     618|     124|     326|       4
---------------------------------------------------------------------------
   17-  206 (121.98/31.94)	......................S.........VISPRKLYEL......QQlydkacGELQV..LT.TKEYALDQRHLILL..RGYELQERSP...AVELKEVKQ..DLLSPRK...QPNNLV.SMSAASSVAVAStsmnFTPsnvntlltaqsilshkGQQQQ.........Q......PIPTQAaVTINMK..PkMS.VASmQRDVqdkQQVAG.SIAGqvqpnqtmvqqqaqqqlqhqqqqqqqhqqqqmSVLPalQQ
  219-  385 (214.30/55.22)	QQHAGIQHvHQAIAQQPQQL.QS.........VMQPQQIPNI......QQ......PQLSLAQLP.GKKGLTKEGFLKMM..QALPPEARKK...FIEDLKVRK..NQQQQQQvtsQAAGLVnSQTAASSSAVDL....IQP..........nitiakPQSSQnigaatatvQ......GIPTST..TAGLA..P.MSaVAA.ARDV...VRIAGvTVSN................................SRLP..NQ
  453-  572 (84.93/ 8.97)	QQQPGMPQ.QQANLQQDQLLnQQatmpsvsnmVFQPDQAGNVmsqtivQQ....nnPPL.VAMNPvNRAGVARP..LKILwnGVLEWHERTKtstMTQDQRIQHciN..................................................................csvsadPIPTST.ATVGQRnlP.................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.03|      49|      95|     669|     723|       5
---------------------------------------------------------------------------
  692-  789 (52.66/17.35)	GPRNPI..PPVAAS.NGQ..VLSQ....KDLQEFVKRL....QQQkqqqhqqqqqqqqqqqvqqqqsnqqllqqaqqmsqvgirpqgmVGQQQQQQVPtqtQQlPsnNAQ.L
  790-  871 (48.39/11.27)	..KNLLlnQAQAQS.QGG..QLQW....NQPQQLGQ......QQQ.........lgqqqqlgqqqqqlgqqqqqqnlllqpqqlqqaaVAMGQQQRMP...QR.T..MSQvM
  876-  925 (43.98/ 6.40)	GFAQGI..TVQGGSmGGQraILQQgmnpQGMQGMGKPMprqqQQQ............................................QQQQQQQ................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.89|      19|      26|     573|     591|       7
---------------------------------------------------------------------------
  573-  586 (21.47/14.53)	.....CRSFHLNFW.VLTLR
  587-  606 (30.92/24.32)	HGDTSSGFFHSQFAgCIHLS
  610-  621 (14.49/ 7.30)	QSDTSIRVLLL..W......
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16266 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAVAMGQQQRMPQRTMSQVMQQGGGFAQGITVQG
2) ARKKFIEDLKVRKNQQQQQQVTSQAAGLVN
3) ARPQMQVPGMIQRPANMTQVMGPRNPIPPVAASNG
4) GMVGQQQQQQVPTQTQQLPSNNAQLKNLLLN
5) MGGQRAILQQGMNPQGMQGMGKPMPRQQQQQQQQQQQQQGGKGGLRDDLSLMDLLQP
6) SHKGQQQQQPIPTQAAVTINMKPKMSVASMQRDVQDKQQVAGSIAGQVQPNQTMVQQQAQQQLQHQQQQQQQHQQQQMSVL
7) SRLPNQGGQGFNPQQPNNPLLSNHLQQSGMPQQQQTSLQQQQQQQQASLQQQQQTTLQQQQNVNLQQQQQNAMQQQPGMPQQQANLQQDQLLNQQATMPSVSNMVFQPD
852
282
671
765
888
121
380
885
311
705
795
944
201
488










Molecular Recognition Features






MoRF SequenceStartStop




1) MGKPMPRQQQQQQQQQQQQQGGKGGLRDDLSLMDLLQP
2) RAILQQG
907
892
944
898