<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16263

Description Putative mediator of RNA polymerase II transcription subunit 13
SequenceMPHSQEDLQDGNLENLYEHDNSGERFSQPHKRLRQERRTRSCLDSNVFSLQNDVDTLQRVKTPDFDPYEFMDTSPTEGGSSSTRSKGKDGKGKQRGLQQRRNSIKKGKKQEEEAQRKAEGEKARQEAMTPMNVSYPNEPFKMGDFGVPLLPRPESSSLTTEKDLQITLNDFESLFESSDEDDDRVPLTNVSSDFPCGANSEENLSTRTLFGSSISSSSMSGPLTGGDLGRMYPTPPSEEQTHFSPVNHPCPELSSNLTSYGSNQTRDMTVDWTYVYKVPAVEKIVGATMYAPLKSLPSSRCPPLKVPEYCIYKPSWQLPLSPKPELIPLIKESTIPMVPSVERPTSIQPTVWTNPIGRDHGISRHVPRQSGAQECRQPGPAPAASEASSFRNLNSIEQPSSAAICPNFVKDGVEELHRTSKIVLKLIQDQCHSPYSSLQSLLSVIRERTEYQYGQIARSNLEYLDACDACVSAIDDGRHLSESAGRGAWDPQYLRHRCLHTWAYNPGYVRIPLSSQDIVQVLRSLQPLLHDAIQKKRTKRLWERPYAVQGPLTWQVFFNIAIQDASESPEPLPVPPLLVGYEKDWMSSSPYAVLYWEKLLLEPFSSSRDIAYIALVPDQEFICKRAKTFFKELTSVYESCNLGRHVPMAKSMRNGILRIGQKYASKVESEQVDSWFSDINELPEAAKIKVFAQVCKAYVAPYLMKDPQMHRCLPANQPKWIGPMLHTARYLSAHQP
Length736
PositionMiddle
OrganismStichopus japonicus (Sea cucumber)
KingdomMetazoa
LineageEukaryota> Metazoa> Echinodermata> Eleutherozoa> Echinozoa> Holothuroidea> Aspidochirotacea> Aspidochirotida> Stichopodidae> Apostichopus.
Aromaticity0.08
Grand average of hydropathy-0.637
Instability index61.01
Isoelectric point6.53
Molecular weight82975.71
Publications
PubMed=29023486

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16263
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     470.21|     151|     190|     147|     336|       1
---------------------------------------------------------------------------
  155-  323 (244.41/203.93)	S..SSLTTE...KDLQITlndfESLFESSDEDDDRVPltnvssdFPCGANSEENlSTRTLFGSSISSSSMSGP..LTGG..DLGRMYPTPPS..EEQTHfSPVNHPCPELS..SNLTSYGSNQTRDMTVDWtyvykVPAVEKIVGATMYAPLKSLPSSRC..PPLKVPEYCI....YKPSW.QLPLSPK
  346-  516 (225.80/131.45)	SiqPTVWTNpigRDHGIS....RHVPRQSGAQECRQP.......GPAPAASEAS.SFRNLNSIEQPSSAAICPnfVKDGveELHRTSKIVLKliQDQCH.SPYSSLQSLLSviRERTEYQYGQIARSNLEY.....LDACDACVSAIDDGRHLSESAGRGawDPQYLRHRCLhtwaYNPGYvRIPLSSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.70|      11|      42|     542|     555|       2
---------------------------------------------------------------------------
  542-  555 (20.11/15.79)	W..ERPYAVqgpLTWQ
  585-  597 (20.59/ 8.03)	WmsSSPYAV...LYWE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      60.12|      14|      15|      88|     101|       3
---------------------------------------------------------------------------
   72-   84 (14.84/ 6.59)	.DTSPTEGGSSSTR
   88-  101 (25.07/16.71)	KDGKGKQRGLQQRR
  105-  117 (20.20/11.90)	KKGK.KQEEEAQRK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16263 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPHSQEDLQDGNLENLYEHDNSGERFSQPHKRLRQERRTRSCLDSNVFSLQNDVDTLQRVKTPDFDPYEFMDTSPTEGGSSSTRSKGKDGKGKQRGLQQRRNSIKKGKKQEEEAQRKAEGEKARQEAMTPMNVSYPNEPFKMGDFGVPLLPRPESSSLTTEKDLQITLNDFESLFESSDEDDDRVPLTNVSSDFPCGANSEE
2) SSSSMSGPLTGGDLGRMYPTPPSEEQTHFSPVNH
1
215
202
248










Molecular Recognition Features






MoRF SequenceStartStop




1) LQRVKTPDFDPYEFM
2) SIKKGKK
3) TLNDFESLFE
57
103
167
71
109
176