<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16261

Description Putative mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMYQALFSEYLGCPQHRTIILGLGTLLQCITIKCPSAVIWINSSDAKDKHIASPGSPLDILPFPPSSLPISGGPTLQNHQIRGALRHIENQIKVRSRAVELRWSSDKCQDSDTGHTISKELQTLEYLDKHNFEKCDSNNSLDSLYHKIFPGASQREGSEVPFGEEPVILLLCSWAVCPQRSGEHRAFVVTHLLERRMIELEDEQTFDQDQLESKSGTIMNQFLENQAPPVFQRILQDFLDNQAPVADENSSPEEKRAFSSLILLFSQLIQNEVFSLDAYMCLLISRGNLINSIPLGIPSDQGLDGQGRPRGKEVKDEVDDGKEDSSDRSDDYDIFDKPPPAPAPPQDMGAQENQSYSFQQKFIMETLQNQKYESNSDVYDDDQDSQESEDQEKKSEEDSRSPSPQVLKLNRHLLYSKHFPLPQGKSPPMKQTSVCYYFTDMAKKTDSLEKRLKVDSGQDVAIAKLKLLPYFDQHLLTTAAAKHILERVQTCTRSGWETLPSLEQIICLLDLLEDALNIHGMLEFIVKLLDHINVLDSEVLKDKAPENYTTNVCLSIVGVLRRYQACLLGSKDQTATIFELLCGVVKHVNNVTNCTSAERCILAYLYDLYMSCSFLKVKFSDMFSSVASKVKEQQTTNIQPSESNLKWNENYMQEYIANPKSRHFNLSTLGKQLSENSVNRYSFVCNALIAICNTGSMERIRDLSILCAELTASCNGLISEWLGVLRALCCSSNHGCGFTDLLCEVDKVDVSDTSTHDKIAMFTAILIARHCFSLDDVVEHVAMASLIAATPSFSGDYNFIAVLPGAVEMDTDAEPGARLMCHLLLRLFCSSLVGGTVSSQPDEQKWISILSSCDRHLLEAAHRGISVDPLVGVLKALLLIGRSDRNETYQ
Length889
PositionKinase
OrganismStichopus japonicus (Sea cucumber)
KingdomMetazoa
LineageEukaryota> Metazoa> Echinodermata> Eleutherozoa> Echinozoa> Holothuroidea> Aspidochirotacea> Aspidochirotida> Stichopodidae> Apostichopus.
Aromaticity0.07
Grand average of hydropathy-0.278
Instability index53.02
Isoelectric point5.09
Molecular weight99427.70
Publications
PubMed=29023486

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16261
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.84|      11|      15|     217|     227|       1
---------------------------------------------------------------------------
  217-  227 (22.22/14.38)	IMNQFLENQAP
  233-  243 (21.62/13.79)	ILQDFLDNQAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.38|      17|      21|     676|     692|       2
---------------------------------------------------------------------------
  676-  692 (32.35/20.32)	SVNR...YSFVCNALIAICN
  695-  714 (26.03/15.02)	SMERirdLSILCAELTASCN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.37|      21|     163|     557|     585|       3
---------------------------------------------------------------------------
  506-  526 (36.05/23.60)	CLLDLLEDALNIHGMLEFIVK
  565-  585 (36.32/18.34)	CLLGSKDQTATIFELLCGVVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     330.59|     109|     265|      46|     184|       5
---------------------------------------------------------------------------
   46-  184 (160.30/167.63)	KD.....KHIASPGS.PLDILPFPPsslPISGGPtlqnhQIRGA.............LRHIENQiKVRSravelrwSSD.KCQDSDTghtiskelQTLEYLDKHNFEKCDS........NNSLdsLYHKIFPgasQREGSEVPFGEEPVILLLCSWAvCPQRSGEHR
  314-  450 (170.29/107.57)	KDevddgKEDSSDRSdDYDIFDKPP...PAPAPP.....QDMGAqenqsysfqqkfiMETLQNQ.KYES.......NSDvYDDDQDS........QESEDQEKKSEEDSRSpspqvlklNRHL..LYSKHFP...LPQGKSPPMKQTSVCYYFTDMA.KKTDSLEKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.46|      30|     130|     593|     629|       6
---------------------------------------------------------------------------
  593-  629 (38.73/51.75)	CTSAERCILAylyDLYmsCSFLKVKFSDmfSSVASKV
  729-  758 (56.73/41.28)	CSSNHGCGFT...DLL..CEVDKVDVSD..TSTHDKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.05|      15|      20|     759|     774|       7
---------------------------------------------------------------------------
  759-  774 (22.95/18.86)	AMfTAILIARHCFSLD
  781-  795 (26.10/15.74)	AM.ASLIAATPSFSGD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16261 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQKYESNSDVYDDDQDSQESEDQEKKSEEDSRSPSPQVL
2) PLGIPSDQGLDGQGRPRGKEVKDEVDDGKEDSSDRSDDYDIFDKPPPAPAPPQDMGAQENQSYS
368
293
406
356










Molecular Recognition Features






MoRF SequenceStartStop




1) RHLLYS
2) YDIFDK
410
331
415
336