<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16258

Description Mediator of RNA polymerase II transcription subunit 31
SequenceMNAGLVTEQQDPEKLRFQVELEFVQCLANPHYLNFLAQRDYFKDSRFVNYLKYLQYWKDPHYAKFLKYPQCLHFLELLQYESFRKELANAQCVRFIEDQQLLHWQHYSYKRMRLQQSHLDNLHQQHAQQQQQQQQQQSTHQQTTQQQSGMLPPPQQQPASSQATGLPFAGLQPQHHQPGQPLQSQTRLLQMDQKPLQSLPQNSLNTK
Length207
PositionMiddle
OrganismStichopus japonicus (Sea cucumber)
KingdomMetazoa
LineageEukaryota> Metazoa> Echinodermata> Eleutherozoa> Echinozoa> Holothuroidea> Aspidochirotacea> Aspidochirotida> Stichopodidae> Apostichopus.
Aromaticity0.11
Grand average of hydropathy-1.005
Instability index77.83
Isoelectric point8.72
Molecular weight24683.47
Publications
PubMed=29023486

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16258
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.93|      28|      28|       9|      36|       2
---------------------------------------------------------------------------
    9-   27 (27.02/10.63)	..........QQDPEK.LRFQVELE.FVQCL
   28-   57 (45.56/21.78)	ANPHYLNFLaQRDYFKdSRFVNYLK.YLQYW
   58-   72 (25.35/ 9.63)	KDPHYAKFL................kYPQCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.55|      15|      19|     151|     166|       3
---------------------------------------------------------------------------
  151-  166 (25.10/13.37)	LPPPQQQPAS...SQaTGL
  171-  188 (24.45/ 9.15)	LQPQHHQPGQplqSQ.TRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16258 with Med31 domain of Kingdom Metazoa
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