<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16243

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSSEQWRAFLHQCLMRRIDAAEFKNLSKILSRRCPIAEGTLLDVLLEIRLATGIKWDPLLPLYIDCLCKMGKVQTSTVLTSLLKYSSIHDKPQCPGSETVQSKKALKCYTLMTDIRVIQDAMLSVSTGSTPKSLAEAVGIFSAIIDWIQAVVAWHNNHIDPSQQTGGLMSSPDAVSLFESLGILLTALSGTGKGIEVLSSDSHEALKVKLGQALSAYLPLCMEVSLPLRNRLDSLQKGYNLYGEPPNKSLQSMMDNVNVNALQFEASVMDGPVINSRAGLYIYINAMLMGRPLVDDSMLLNYLTNRYGGHYDVLVEEVITATFDVLSNALYRNESSRTMFLFRSFLVNKLPSFFAAMLAASMVSLPMEMCISHALSRLDPNTFPSFSQMFAMQGSTVLSEVRPEFLFACASHKLIPESSIERLLGENPMQTPPVGYNKDDLMSQINTNQERAEQLVSELESTEGNAGAIVAAITEVMHNLCNQKETMTLKSICNSLSRRPQALDVILLFRSAKQVLQPLCTLLDSWHWDEDQGESQPVYDEFGSILLLVLTFKYRYDLRPYDLGITSNDSFVLKLLDCGPSSQKLDDLSEKQNKNLGAWITALFIAEGISEETMSSCSPQEFYLLVTTLFNQSLTACEAGKLEFDTLKGGFEYLLEPFLLPSLVVALTWLGNHIWETESDPTIPLKTLQSLVNPSSISGDAREIHKTVLNITARSLDEQLKDIRSRHPNRADIKPILDVLEPCLSFQRTGSCHRSELDSWTTHSPGGLLGSIRSTFQGLVLWSTSPGVSMAPHFYTHRQLVAGIRMLGSARVLTAIVDELKMQTETGNADLALDIAVTMICAPLAESFAIEQSNYHPVDPNKEPLPRCPVLTLRDALNLQHENVPKLSEKDPLRAEVIVRLYRRVNALMTPTSQMPNLDMSNIIQDMQLGVEDHGQMDLEPAGAGHGVGDDDAANLNRMLDNAAAAAAAGLDSGMGQGMGGGLDTSIDDVLNAADMAVGNPEFLDLDMEGMF
Length1013
PositionTail
OrganismAspergillus arachidicola
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.040
Instability index50.14
Isoelectric point4.95
Molecular weight111523.67
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16243
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.49|      20|     296|     192|     235|       2
---------------------------------------------------------------------------
  189-  208 (31.13/57.18)	LSGTGKGIEVLSSDSHEALK
  233-  252 (34.36/ 9.45)	LDSLQKGYNLYGEPPNKSLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.61|      34|      42|     292|     333|       5
---------------------------------------------------------------------------
  253-  288 (54.38/39.82)	SMMDNVNVNALQFEASVMDGPVINsrAGLYIYINAM
  298-  331 (57.23/35.63)	SMLLNYLTNRYGGHYDVLVEEVIT..ATFDVLSNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.77|      25|     232|     490|     548|       6
---------------------------------------------------------------------------
  524-  548 (47.47/77.24)	LDSWHWDEDQGESQPVYDEFGSILL
  758-  782 (44.29/12.76)	LDSWTTHSPGGLLGSIRSTFQGLVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.57|      20|     620|     115|     134|       7
---------------------------------------------------------------------------
  115-  134 (35.28/21.00)	DIRVIQDAM...LSVS.TGSTPKS
  733-  756 (28.29/15.44)	DIKPILDVLepcLSFQrTGSCHRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.03|      11|     831|      34|      46|      10
---------------------------------------------------------------------------
   34-   46 (16.49/16.64)	RCPIAegTLLDVL
  868-  878 (21.54/13.18)	RCPVL..TLRDAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.83|      15|     302|     341|     358|      11
---------------------------------------------------------------------------
  341-  358 (23.32/27.37)	FLFRSFLvnkLPSFFAAM
  654-  668 (26.52/19.72)	YLLEPFL...LPSLVVAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16243 with Med5 domain of Kingdom Fungi
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