<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16241

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHSSAGVQSWGHPLRAVNSGSGHVDASQAVGPSDPQFEKLPTPVPQPQPRQPAVIDLTTSGGDAQELEPPPKRLRLDLPAAPSARDVSPAPGSGGELRSTPGTGGSKPPSLSWRNRPVWSFQAMLSEVPGSNVMNEEDATAVAQGGKPASPPSLPVLPWKYVPESLGSNPTTSQASSPVKEVQTIPYRIETPSVAPVLKGEKVADFSPWTGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQNHSLVTAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRKLSRTIPHGIRGKALLDQCLNKGIPVSRAVWLAKCVGANEIRAFKRKGTSGTLALGLEAKWVRDWTASVQQFLEGVLGACGCAQWKMKMTYAVSLTARLFFERLLDHDQYLGWFLSSLEAAPVNTVPVWLLMLGIYWDNIMRYRKRGRRLAELLLVKLRQVTQPEKGGPLQPLVDRLSLYVRRLVLEHTSSVVLPGSWENHKELISSCLNLKDNVHKTIYQNLSERNSRLQLPKNHQDTAERSPQQRVIQLFDSIRSAHDISSASTACLKTIEDKAMLISKLLEWTATPFRYGLCRVYTGVRLLRKWKMSGIDVDSYILSFLADVRVTSALNMENIYHIISELVRSQTFSVGRYLQWLMAKGVTNTPQPVSSDLCLLKQLPANRLPEHVRNLRNTLLYRAGIPVMEEDSAIAELKISIAQRLPNIFGAEMDSAMPTESSQPNPTWAVKSEIGQWIRHGVAGHCRDSPRKLSGVSVAVDPGASALTPDEFYSVREILETFGDLSMLADILKQATRCDDDVVLASVADTVNCHFDCFCVIGATADLFRGLVESYARLKRLGNASLDLLFSLIELGLRIPSEFNTVGLLRQDLTRLENKSALAAPSPLSDSIPLALSDVDPSFQEKLNQLLSSGGGMDESTMDTVFYSLMHILESSGSPAKLSANETARYLAYLRPFQPKHFDTMLIRWICGLLKSSTPSISRILPPLIGVGCVTIHAFVFLVKKLLQSEKVAAVIPNLAGLRVDLLQLLVPLVSGKSKYADLVTYRFHVAQQEFFMKHPQETLDIICDAVALVNSETGSNPGQPDIAGCATELLDILLTQNPEVTVQYCLQGFIGKHSTSTTVLERALDNLLGFDSLAGPPTMSEAEKVVRMTDDFSLPFCQLKLQMLFNAESGRNVGNGIVDVMFKAAVEDTQSKGSNWVGFVGLMSQDVIRQIRERAERALFSIPLFEEHIEAHGHPGTAKSLETAKLYLTIIEKLAYSVPEAGVQSVAPILVEKMDLLLHRLVIMQTNFNNVTMNRHGAATTQILQSRSNFERSLAFWFSAFLRMIVIHRSAFTMPSPAPRPNALQEQSRLLISILCISLARLPDSVIRLFPAADYFPHPIPSEGYRPCPGILLQTHALDVAASLIDTFPDEARQHCARFLKEKCPPFLQYQNDSRFIYLLGPMSDAAALNSLQTASLPSPAAGGSTPTPTPSSALPGAPSNPQPTAMTPSVTSASLSEGINCVASHLRLQYRGRVMGPYPVRPWELLEDAAPIVGVNDTAVNLKFFDARRVRA
Length1586
PositionKinase
OrganismAspergillus arachidicola
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.127
Instability index50.20
Isoelectric point8.52
Molecular weight174393.35
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16241
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     329.32|     106|     151|     791|     904|       2
---------------------------------------------------------------------------
  791-  904 (162.55/126.20)	GASALTPDE.FYSVREILETFGDLSMLADilKQATRCdddvvLASVADTVNCHFDCFcVIGATADLFRGLVESYAR....LKRLGNASLDLLFSLIELGL...RIPSEFNTVGLLRQDLTRL
  944- 1057 (166.77/107.86)	GMDESTMDTvFYSLMHILESSGSPAKLSA..NETARY.....LAYLRPFQPKHFDTM.LIRWICGLLKSSTPSISRilppLIGVGCVTIHAFVFLVKKLLqseKVAAVIPNLAGLRVDLLQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.94|      53|     156|    1258|    1312|       3
---------------------------------------------------------------------------
 1258- 1312 (83.25/63.63)	FEEHIEAHG.HPGTAKSLETAKlyLTIIEKLAYSVPEAGVQSVAPILVEKMDLLLH
 1409- 1462 (93.69/64.83)	FPHPIPSEGyRPCPGILLQTHA..LDVAASLIDTFPDEARQHCARFLKEKCPPFLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     368.43|     120|     166|     492|     625|       4
---------------------------------------------------------------------------
  492-  625 (181.83/145.26)	VRRLVLEHTSSVVLPGSW......ENHKELISS..CL..NLKDNVHKTIYQNLseRNS...RLQLPKNHQDTAERSPQQRVIQLFDSIRSAhDISSASTACLKTIEDKAMLISKLLEWtatpFRYGL...CRvyTGVRllrkwKMSGIDV
  651-  786 (186.60/113.71)	ISELVRSQTFSVGRYLQWlmakgvTNTPQPVSSdlCLlkQLPANRLPEHVRNL..RNTllyRAGIPVMEEDSAIAELKISIAQRLPNIFGA.EMDSAMPTESSQPNPTWAVKSEIGQW....IRHGVaghCR..DSPR.....KLSGVSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.82|      33|      36|      23|      55|       5
---------------------------------------------------------------------------
   23-   55 (61.48/31.00)	SGHVDASQAVGPSDPQFEKLP.TP.V.PQPQPRQPA
   62-   92 (46.27/21.27)	SGG.DA.QELEP.PPKRLRLD.LPaA.PSARDVSPA
 1489- 1522 (43.07/19.23)	SLPSPAAGGSTPTPTPSSALPgAP.SnPQPTAMTP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     258.39|      76|     936|     169|     299|       7
---------------------------------------------------------------------------
  111-  162 (73.12/84.10)	.........................PSLSWRNR..............PVWSFQaMLSEVPGSNVMNEEDATAVAQGGKPASPPSLPVLPWK
  220-  295 (127.30/55.96)	LNEQTAKQGHYDRTQVSQNESNTARPSLYAQLK..............HRSGLQ.MLSSVFAAALEKRQNHSLVTAPSTFKPPPRVTLTDNK
 1321- 1380 (57.98/12.99)	FNNVTMNRHGAATTQILQSRSNFERS.......lafwfsaflrmiviHRSAFT.MPSPAPRPNALQEQ.......................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16241 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GEKVADFSPWTGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARPSLY
2) LPSPAAGGSTPTPTPSSALPGAPSNPQPTAMTPSV
3) MIPHSSAGVQSWGHPLRAVNSGSGHVDASQAVGPSDPQFEKLPTPVPQPQPRQPAVIDLTTSGGDAQELEPPPKRLRLDLPAAPSARDVSPAPGSGGELRSTPGTGGSKPPSLSWRNR
4) MLSEVPGSNVMNEEDATAVAQGGKPASPPSLPVLPWKYVPESLGSNPTTSQASSPVKEVQTIPYR
202
1490
1
126
248
1524
118
190










Molecular Recognition Features






MoRF SequenceStartStop




1) ELEPPPKRLRLDL
68
80