<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16238

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMLDHCRRYGSLDSLDRHGHTSTLPSGNFKERTSSTDSAMTMPTGHYDAKLRGRSKKKAPPPSPIVGHKAHPTVRDGFDESSADEEEDSISGLHSPKGRCPRDRSRTKSREDSDAYSRASKSPPLSVTSRMRHFSLQSTTTEPTASIPPTSSSRHTSYTSSIPSVPSEDPRLGHRPSPRDTKFMHRPKPAPVAEQELVPSYDDLYGYTADKLFFLAVIVQAVSGEYIRHQHARLLGASSKIYVCMGGSFNPPLPISPAGRGVADGTRIAIKGSQFKQCVDCQLRSTYSDPSSGETDVDWGLYNLRYTFTSCVYGFPKSVSNISTQCTVNCQPLDRALEFDLTDPGANNFYTWCGTTTFADNLITQCEQCYNFTLTQTQDPTNGQSQVFMANFLEALRYNCHFRTPTGFAFPISPTRIFSESLLPSSTVDLINPTSTGGPGVNLALVIALPVLGFVILLCALSICCFFFIRWRRRKARKHRQSSHLHARWNDTGISTPWANYHEMYSPTMYQQGHGQHQQQQGFSFVDNDGQYRDVGYSKNLTEVTASAVATPPLNLSPDGEKQKNPEYPEYLGQDSKQKRSSLQSQASIISNNLLSVSDHLSDNRDLLTSLVAYPGPDYPGRTQANTLEQLLRTKLDPRVEDWVARGRKAGASALEDKSGLAEAELAELWDWAPVEANQEARRRNWGGNFTLEEREMGVQNVVTGLARVLEDEGSESEDEEEGEEDEMEIVGVRRQSAGAGFEFDIAPASAAQHQQQKFVEPAVPLEDILRFMTTGAEPGKR
Length781
PositionHead
OrganismAspergillus arachidicola
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.617
Instability index52.22
Isoelectric point6.03
Molecular weight86581.31
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16238
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.72|      53|     298|     250|     342|       1
---------------------------------------------------------------------------
  268-  321 (95.14/90.23)	AIKG...SQFKQCVDCQLRSTySDPSSGETDVDWG..LYNLRYT..F.TSCVYGFPKSVSNI
  356-  416 (80.58/28.79)	TFADnliTQCEQCYNFTLTQT.QDPTNGQSQVFMAnfLEALRYNchFrTPTGFAFPISPTRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.24|       8|      23|      31|      52|       2
---------------------------------------------------------------------------
   22-   29 (15.13/14.53)	TLPSGNFK
   40-   47 (17.11/ 7.63)	TMPTGHYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.06|      21|      23|     119|     141|       3
---------------------------------------------------------------------------
  119-  141 (29.69/25.27)	SkSPPLSvTSRMRHF..SLQSTTTE
  145-  167 (34.37/19.59)	S.IPPTS.SSRHTSYtsSIPSVPSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.82|      17|      21|      71|      90|       4
---------------------------------------------------------------------------
   71-   87 (29.77/19.58)	PTVRDGFDESSADEEED
   95-  111 (32.05/13.53)	PKGRCPRDRSRTKSRED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.67|      17|     235|     515|     534|       5
---------------------------------------------------------------------------
  515-  534 (27.92/24.67)	QHQQQQgfsFVDNDGQYRDV
  752-  768 (31.75/18.63)	QHQQQK...FVEPAVPLEDI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16238 with Med8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVATPPLNLSPDGEKQKNPEYPEYLGQDSKQKRSSLQS
2) RRYGSLDSLDRHGHTSTLPSGNFKERTSSTDSAMTMPTGHYDAKLRGRSKKKAPPPSPIVGHKAHPTVRDGFDESSADEEEDSISGLHSPKGRCPRDRSRTKSREDSDAYSRASKSPPLSVTSRMRHFSLQSTTTEPTASIPPTSSSRHTSYTSSIPSVPSEDPRLGHRPSPRDTKFMHRPKPAPVAEQ
3) VTGLARVLEDEGSESEDEEEGEEDEMEIVGVR
547
6
702
584
194
733










Molecular Recognition Features






MoRF SequenceStartStop




1) FEFDIA
2) FVEPAVPLEDILRFMTT
3) HYDAKLRGRSKKK
4) IVGVRR
741
758
45
729
746
774
57
734