<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16237

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVVMDNTKIGGAGQGSAIHDSRNGMPSLTPNINRTSAFGDSHAGRVHINGMTKNAVDPSQAEDASTVNIISTKSMELPGLPHITQGFFPFSKLISRSVQQSWNDLSDLITEMADIKVSPQEQNSLQLPASGKSFGNQSPENIRKKARILDFAHAKRAEFIKLLVLSQWSRQAADVSKLIDLQNFIRTRHQAYMGALQGIGDMKRDLVQAQVANPDLTTALEVLSKGKVSSMSDLGYKPPRLLTGKDTLKRLQKINRIISVRLALYDSVPRAFHSYSIHDGRVTFVVPNEFELDLSIGQEDESSQLYFVDIRFLFNPSSPILKGRIFNEFDVKINDALRNDGLSGCFDLLHSLVLTNKINILFKQAMELARGLWYDVLRVELLHRTLVVHYWTQKAGAKSWLEIGIKSGRICGENDSYSHPNLGLRWIRDGQEVDSEEIEFNTESLSMECILRSVIALHISHILSSAYCIISESLLYSAGRLSLQAQLARTEPGDCGLAIQLTESRHLSVSIEPMSGASIISATPNAQERLDNDRSSDKSSAEHIVARVARLRCMAAIDEIESNVKMLGFETVNPRSLKIDFRRMFPSNVLRFSFFWHHLWERNWIVAATSSMDGDNWWVVQLQKTTTTESHSVFDASTHISSTLRSAQVISGSFFHVSQNIGYPSFADLGHYLSGILAVHTNARYLADLQSVDFYPPLQRLVIEPNLQVPEIFMRYEAANIPEAFRIALPSGLKSRVRTKGTIRLAFHGIDPCKKVATIVAYGNLLIPIKAFSALNSTWDHSLVFQKRGTGFAIRLLAPPGRPVIPKLIENLQRLDCVLSIFECLQRKKMEPRSLSLSHVTFAYGPEKDLLATLNIETSMPPSSVELDPIFLASRTKSLFHLRLGLSFEFPNPHRRIQKSIESTLNHSTTDAVLDTVAELLLLTLPLMRALDQILMNPSNKQPLRVQVTVRNAKTFQIHYPGQSFRFQLVATHHLGHMVWILKELSSPKEGSNQDQLKLKLRERLYNSKGDGWRGLGNGVVAETGKVGNLLTELDKCFEASSTPGLTPEVKANGSKSFSQQSTAENGNLDGTLSESATLIPAPNATSTRHKTGDTTQNADIIMID
Length1108
PositionTail
OrganismAspergillus arachidicola
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.190
Instability index50.10
Isoelectric point8.72
Molecular weight123267.48
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16237
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.60|      15|      16|     630|     644|       1
---------------------------------------------------------------------------
  630-  644 (26.39/18.26)	TTESHSVFDAS.THIS
  646-  661 (21.21/13.12)	TLRSAQVISGSfFHVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.97|      12|      16|     271|     284|       2
---------------------------------------------------------------------------
  271-  284 (18.80/20.17)	VPRAFH.SYSIhdGR
  289-  301 (18.17/10.12)	VPNEFElDLSI..GQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     507.59|     168|     374|     433|     619|       3
---------------------------------------------------------------------------
  433-  619 (253.08/249.58)	GQEVDSEEIEfNTESLS.....MECILRSVI...ALHISHIlSSAYCiISESLLYSagrLSLQAQLartEPGDCGLAIQLTESR.......HLSVSIEPmsgasiisATPNAQERLDNDRSSDKSSAEHIVARVAR.....LRCMAAIDEI...ESNVKMLGFEtVNPRSLKiDFRRMFPSNVLRFSFF.WHHLWERNWIVAATSS.MDGDN
  804-  996 (254.51/192.57)	GRPVIPKLIE.NLQRLDcvlsiFECLQRKKMeprSLSLSHV.TFAYG.PEKDLLAT...LNIETSM...PPSSVELDPIFLASRtkslfhlRLGLSFEF........PNPHRRIQKSIESTLNHSTTDAVLDTVAElllltLPLMRALDQIlmnPSNKQPLRVQ.VTVRNAK.TFQIHYPGQSFRFQLVaTHHLGHMVWILKELSSpKEGSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.07|      14|     289|      70|      83|       4
---------------------------------------------------------------------------
   70-   83 (24.97/15.81)	VNIISTKSMELP.GL
  361-  375 (20.10/11.29)	INILFKQAMELArGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.90|      12|      15|     160|     174|       5
---------------------------------------------------------------------------
  160-  171 (20.40/19.01)	AEFIKLLVLSQW
  176-  187 (19.50/ 6.91)	ADVSKLIDLQNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.89|      22|     264|     759|     781|       6
---------------------------------------------------------------------------
  759-  781 (33.73/28.29)	VATIVAYGNLLIPI.KAFSAlNST
 1024- 1046 (34.16/23.32)	VAETGKVGNLLTELdKCFEA.SST
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16237 with Med14 domain of Kingdom Fungi
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