<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16214

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSEEDWPSPKFREHVIQRLEPELARNRQNAPNLPVPGDARQVEEYVFAKCMSKDEYMRTIAKVINAINCNSKSAAVPSVLQPSQFHSPPCTTAVLGTGVGTPGYRATVPPDPQPTSAQTRNPPVTTATTQASTTPSAPAVTGTVSASAAVAAAVASFPSPDSAALRAAPGGQTTPGAQPSSGAPGSTTPNAPFPNGTQPGAPPMNGGAGGPPMGQPPPQMGAPNMGMNGPGGYGGYGMMNGPPGAGGPMGGNPYGQPMKKEMDQSRGPWDPQGHMYQQQQPWGGMPPQQGHGGYPNRPMNGQQTTPTGTSSSVLESLINQPQQYPGHHNQMAPPGGDRNAAAGRGGVPGNPGGVPGAPQRPGAMPVNQGVMSIEDQNVYQMKLRNMRGSCDSLRTRARQCRQEGNHEAAHKLEVMLSVLEGRRVVSLEYLNHLETWIARKQDFLNINPMGAGNPAHMGMNDPVMNGDHGMMGNGQVHNPYGHPGYNHGQYGMGGPPPPHHMQMHQQQMWQQQQQQRMMPHDSMMMGGGGPMHGGPMYRGDMGHEMNSPVNSHRHNPYPSPAAMRNNMRGMQNGPGPIGRDRNSMSGSMSGPSSGAPSMNPMGTPKMGGPGSIGGLSNLDDFTYDDFLPNPIDALQPTLHVGPGSSMGGGPRVNLNDAARKELQAMEGRFDIEPNHQRHDANHIIVSAKMRNQPVPPLRLVVPITYPSGNVTVDRAAIDLDAYLYDDLQNVVHERLSRPGLSSLTDYLNAWEEQVNQYMQQNQTNGGIDAAFGVGNDFFYDNLNL
Length784
PositionTail
OrganismCaenorhabditis nigoni
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.05
Grand average of hydropathy-0.734
Instability index52.70
Isoelectric point6.62
Molecular weight83433.42
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16214
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     155.05|      32|      33|     599|     631|       1
---------------------------------------------------------------------------
  441-  467 (37.51/ 6.21)	QDFL.N...INPM...GAG.NPAH..MG.MndPVMNG..D
  468-  501 (43.85/ 8.42)	HGMMGNGqvHNPYGHPGYNhGQYG..MGGP..PPPHHM..
  502-  532 (39.86/ 7.09)	QMHQQQM..WQQQQQQRMM.PHDSmmMGGG..GPM....H
  599-  623 (33.83/ 7.10)	..........NPMGTPKMG.GPGS..IGGL..SNLDDFtY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     265.42|      35|      35|     196|     230|       2
---------------------------------------------------------------------------
  169-  202 (44.03/ 9.92)	P..GGQTTP....G...........AQPSS.GAP..GSTTPnapfpnGTQPGAP
  203-  231 (60.91/17.02)	PMNGGAGGP..PMG...........QPPPQMGAPNMGMNGP......G......
  232-  260 (35.29/ 6.25)	....GYGGY..GMM...........NGPPGAGGP.MGGN.P.....yG.QPMKK
  261-  295 (46.75/11.06)	EMDQ.SRGPwdPQG...........HMYQQ.QQPWGGMPPQ......QGHGGYP
  298-  341 (39.54/ 8.04)	PMN.GQQTT..PTGtsssvleslinQPQQYPGHHN.QMAPP.....gGDR.NAA
  342-  364 (38.90/ 7.77)	AGRGGVPGN..PGG...........VP....GAP....QRP......G....AM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.05|      18|      71|      71|      88|       3
---------------------------------------------------------------------------
   71-   88 (33.22/18.17)	SKSAAVPSVLQP..SQFHSP
  103-  122 (29.24/14.98)	GYRATVPPDPQPtsAQTRNP
  145-  160 (25.58/12.05)	SASAAVAAAV....ASFPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.74|      14|     123|     548|     565|       4
---------------------------------------------------------------------------
  545-  558 (27.95/14.29)	MNSPVNSHRHNPYP
  563-  576 (27.80/ 6.17)	MRNNMRGMQNGPGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16214 with Med15 domain of Kingdom Metazoa
Unable to open file!