<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16211

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAARSSLDPTGSVLSLDESSGISDREGFSSAEQDNYSNRKPEDQTRNSSDSEEEDGVVAKNPLPDVPPGCGPPTIPLNVLLDFSIQHVYHEITVLAELMQRKTSDQGEQERKMSLVHFAHATRSQFLKLVALVKWIRVSKRMDVCYSIDYLLDLQSQYFIDTADRLVAMTRGDLELARLPEYHIAPAIDVLVLGTYNRMPSKIKEAFIPPAKITPREQKQVCARLNQLIETRLSRLSSGIPPNYKEIHVANGIATLLVPGEFEIKITLLGETEETKWSLLNIKILVEDYELGMGLPLVHNLQLNQIHGVLQSRMNVAVNPVKEAFFNLHSFCVSLQLDVLYCQTSRMAAGRLRENIVIEKYNPKERILVVGYWVKRSKNKRLTVGQVKIDAQYRVQIYEDKDDKLGGLKVRHFPHAPRLGTIDCASGMLSMDRMLSETFAVRCSERLMRLRRILEAAEPLLEVRMTGSNVPTLSLSLLPDTSSNEEMLTVSVNSFCGKVICNINVLNSENEDLVAFAKALYSSRCSGQTIRDYLQKLRTSLVIERYRRSVAALPVREIKETELLPFVKVMLREAPKQRIILQYTRSENYYLIVGFISEGEDVVTTKLQLLECDDERAQFIPLDNDTEVFQTAVADAVEQGTMRFKICDDRISLIEECSREQRLSFAIITVEDRITYMYLATELQKKGVGVELRRDDAHVPGGLALHITDVKTVVPFDAAEFFKCCVRSCLRIDNRTRHTFQFEMCFENIPLVRDVPHGLAHRREGDKDTTWVQEISQVNQMTPEKLVEGIIHRLMRYLYMYKVVHQFSLAYEQYFKQWCNVEVYTFHKLVVSYGENRDMLMVLAFNVKSQNPGSTEDYFLMNFGQTMPHSQFNTPEVDWLKKPRYNPHAMMSQLLRDELKKNNDLIYIMHYLCETIRPFMVIGKFGRIRFQSQKSLSQLIGPEVFFPYRLKYHLAVLDLTTLRLMRGNVILEIKMLEGQKVAVRDVSRYRARCAGLYQLFSNIGPGTTEIMCEELEIPESDNKINAGPTMWKPEQFMDAVDVPHEDDPRMKITSLPILMTHDTIIKACDFQEIDGHVTCPLDEYLYSISYLQRALLTLERMSPRAQQGPANNLFIEWDGTNATAMVYYKIFLCPEAMTLKIHIEYDEGTNSEATPQNLTALSTYFEKVVFRCGDEYALQSYVLMTRVTSFGATASIANLMNAQMVRREKTGFIVYLRRKKKKKKMSNE
Length1228
PositionTail
OrganismCaenorhabditis nigoni
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.08
Grand average of hydropathy-0.248
Instability index44.83
Isoelectric point6.57
Molecular weight140831.98
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16211
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     234.91|      77|     424|      51|     267|       1
---------------------------------------------------------------------------
  178-  267 (117.56/278.78)	RLpEYHIApaidVLVLGTYNRMPSKI..KEAFIPPAKITPREQKQ...VCARLNQLIetrlsrlsSGIPPNYKEI...........HVANGIATLLVPGEFEIKIT
  949- 1041 (117.34/58.34)	RL.KYHLA....VLDLTTLRLMRGNVilEIKMLEGQKVAVRDVSRyraRCAGLYQLF........SNIGPGTTEImceeleipesdNKINAGPTMWKPEQFMDAVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.98|      24|     425|      51|      80|       2
---------------------------------------------------------------------------
   51-   80 (37.76/41.23)	SEEEDGVVAKNPLpdvppgCGPPTIPLNVL
  483-  506 (43.21/28.79)	SNEEMLTVSVNSF......CGKVICNINVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.54|      40|     419|     343|     398|       3
---------------------------------------------------------------------------
  343-  385 (62.43/71.99)	QTSRMAAGRLRENIVIEKYN...........................PKERIlVVGYwvKRSKNKRLTVG
  528-  594 (58.11/30.49)	QTIRDYLQKLRTSLVIERYRrsvaalpvreiketellpfvkvmlreaPKQRI.ILQY..TRSENYYLIVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.87|      12|      17|     422|     433|       5
---------------------------------------------------------------------------
  422-  433 (21.32/13.02)	IDCASGMLSMDR
  441-  452 (20.55/12.28)	VRCSERLMRLRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.86|      43|      64|     835|     877|      11
---------------------------------------------------------------------------
  835-  877 (76.89/59.90)	ENRDMLMVLAFNVKSQNPGSTEDYF.LMNFGQTMPHSQFNTPEV
  901-  944 (70.97/54.62)	KNNDLIYIMHYLCETIRPFMVIGKFgRIRFQSQKSLSQLIGPEV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16211 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MAARSSLDPTGSVLSLDESSGISDREGFSSAEQDNYSNRKPEDQTRNSSDSEEEDGVVAKNPLPDVPPGCG
1
71










Molecular Recognition Features






MoRF SequenceStartStop




1) VYLRR
1214
1218