Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MPRMGPPSSSKQEPTMFMSFRNPQWPANFINRDNVLDYFCNQGNVFYEMNSCNQQIKMQNITNRSVDECLRNMQGIQYVLWYSQPPLYIVCKQRRNNATNVSPIAYYYVINGSVHQAPDMHTLVQSRLLGALEPLRNAFGEVTNYSRYNTAKGYYWEFKNKPSMKKKEEEKKEEDERKLEERSTNFQKTRTLMLLNQLFTEMPADEALEKIDVEEEEDPKPEEAPSTTSAGEPKFAEPAARATTK |
Length | 245 |
Position | Head |
Organism | Caenorhabditis nigoni |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis. |
Aromaticity | 0.10 |
Grand average of hydropathy | -0.901 |
Instability index | 61.47 |
Isoelectric point | 5.90 |
Molecular weight | 28525.84 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 PIRNR:PIRNR023869 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP16200 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 48.07| 14| 46| 171| 184| 1 --------------------------------------------------------------------------- 171- 184 (22.95/11.14) KKEEDERKLEERST 214- 227 (25.12/12.72) EEEEDPKPEEAPST --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GYYWEFK 2) IAYYY 3) LEKIDVE 4) SAGEPKFAEPAARATTK | 153 104 208 229 | 159 108 214 245 |
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