<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16190

Description Uncharacterized protein
SequenceMSFPTSSAAEEEDGFPEPGVASWYDAQPGKRLLRRPNYRMGTADVYEQHKNQEEDMLTTERLKKGYQVPVTHYELQSLIFNASENKLLRLDRAPRRTYCMISSVVHRRGEYHMNFDSNRKVAKGEMPRFAKIRFKRILEDRVKFFSALFRGTPLQYLQKKVPYYRRKELLLLEFYDYQIRYDRAIWCVKLVSILGFNCSAKAQKKALLDLATLEWSQACGKVTYYLLLALTKTYKKGPKAFKESVKMWYYLTRFMMYMFQDGVVDKHEFLNDLTETFNVFFIKGSLANAKILELFMEYYIFFLDDLSSSLILARRASCLLCKALGLLSEINEAYIKTQFYKNENKQEFMGHQDVWSIDAQPGVDFKDYIGDHKEFIDPDDFFRFVNDLPDAAYFEDYEDKTAEQVAEEELQTMEAPRRARNYIYSALKSVKDHVDIPIDSDDELYIPSDVESLTTPEPEDPEEGPEEDPSKSVPSPTSSAGPASIEDDCWRTRGLVPQTVAKPAPEPVQQPVPQPPPKNLNIKSEPVDLEYEKNFGNPVKSKNFNINIKAEPMDYDEYSTEPPQPLQPPQTFQQRPETPEKEKAPEQPAEPPRWTLAELPKDFFSKNLEVPAPWTRPREKPIERKRGYNLLCTDRFPVNEDVFEEFKDPDSPDGSRPASPVEPIPFKKLHKTPPKRVLTDADEFGHIPAQKRKINPKLANGKYSETLFVYYLINGGVAFDPKHDGDEMDFSNPTPPEAPPPPPPVDFETSPSASPAPDTDKEDDDGKAKEGGDKAAEKSTDKSAGEKEASEKEKTTDGKKDGDKPAEEKSKKDGKAAEEKKTVDEHLNDLIIPMDVEAEAASKRNSATNSKDDEAEDANKVAGDAPVVEATPAAGTSEKHPEAEVTQVETNDVEMESVDSETNKESTSDPTADKPSNGEEPMEVDDPQKKLPSPSAAAEGDDASKKSKEGEKPDAPAIELVDLEALDDIPLPTDDLMLPDEDEIQVIEKPKHPDADFCEVVEVVEKDKDKTPETAGEGEKGAEKEPEKIPEPIPAVEPVPEPVKTPEKPKTPEPPRLYTAEEIEQLKKDKRRQRMLDKLTDAFKIQMESDKKYEENNIHPSFKVYDQSRSFRRPLHLLSSMVQYLAFRTPESFVWNNLEVPRPDKCHKILPQLCGSPLDYLPCELHELPVMEGNDHHVEHLRLRHHEIVRRSQAADENWLPGGADVLQYGRIIDACVDVIGLMDCINVEKPKSIYNVSQRLFNFREKFAKEEALLRIKLMFKWCISEEREGSFRPVYCARMLEYGLTRSVDGLIGGWQIMDLFFNFMATEGPKPGMANYQAKFDACAGIMIELIRHKLFTVADILRELEKDLDIDYTLPLMARQRKQKMPKISKKEKTPEEPDNTKLIHFTTEHTPKRLFMGRKMDLLERMIIMMPQFGNSKDSDEFKIRSQLLFGLRPSENIYFRRAKTICQGICKEFDSKLYIDFNDKLTHHRKLNQSRLDDLLRQFRAQTYHDQHVILEKIVIHLTENIGRFLEKKNAHLPAPEVVNIICEMYEYSMDITSIFDFFEVLHPYLKAVDEKIAAFDLDLVPDMYHTEIAYIFVSFFMKHYQRFLLHKRNNHITNQLYFGIRKMIMDKKRFMTCWGRVIAIFVNHIRPVLIGGGFQIISLEGKEWEFARAHPNKRAFNLECSYNEDFAASQLSSKILRYDSFTDMKWILDNLEGTVKRKNSKPPKPNRYSFVINAFMEARKYGQNFDRINELANYCANVTANDPPLSEYWIGAIRGLCCLSMDIRDPRDPLSLFKEMGRNIDISDCSTHYSLSTFITCLAGKAAFYIPRLLHELTKNVFKLMLHNDGRLTSKQTRDVKRKSANKTTETRTLSEAEPGVCLSLLIIAGLCCPGDEPFGLSVHYRGIEKKKKRFSETADERIMHMFHWLEMDKSMFRTLASISELLEALQSRYRDANLVLPQSFQLKHQIVDPNKPPPHEKAPYRPQFLFNIAKAVFFTICEQDWVTIRMYQFVRIKQMEPFNQEKLKKNCLGQQLLRISLRRKTERSNVHSLFEAHKISKKATVDKVLSFMNLWNFRATLFDLMLMIKEISPDGNTKHAQQGAIAADALMSEIGKCCRDMFLAAYKADAKMPNVKKLMDFRFGDISKYWLLAPLVRMCPKPINIPPQYANTHVQTVASKFLKEASALMDTPPTTTPKERLLQCSWAMSKLPFINMILTCLACEKTQNGKDTFLNSVYQQLQREVFRDHNKRSKWTNRPEHRDCTVLRVNLIAYMYKEILKPTHVEVWGLLLYQLMFHGIINPSRERYVFENCYDMLQHMVLWTLVNGDNMNSHDRYGSIRVRWPNYAGLMKKIRKEIQDRHVHPSRTCLLRFLPIGKLQTSTISYKKYHKRTIRPSAVKSKKFMSNEGIRSGKYVYLPEEKVKTNAYDHMKNVPDGIQKGGWKFRMFQTTRLDKVGKSVLHQLRAKIPHTHIGEFKRPCNIMLDNMSEDFYLRPPEVEITKTVEPVADDEETTVVKKPEEESAEKKKDEAKKADEKTTKADDEKKNDETADAKKDNEKQKEEKDKPEDSAKAKTDDVTAKDTEKDTSAPTDAAKAAAAPVAAAPDANKEMDTSTPKPAPVTRETSTTRGRGGGRKRNSGGRATGGSRAKRTNSRANANAETAAAAETSATTKAGASGGGSSNYHAAMRANQPPMSNGSSDETKANIRNLLNRKQEKRNSLADANAAAAVAAAAAAAAAASGNIAPALAPIVQPGIPAAGATTQQQPHPGMQHQGMGSGMGAGMGGMNPTMHAPPPYSSSSMNPFANQPHFAAPNPGPITTMAHRSAAAVTPEERARIMEEQMHQKLAQQQQLIEQQNRQREAREREAREHQERLAREAKIREEQMQLERQRVIEENNRKMEEQRIQREKEEAARRLEEQRRRDEEARLAYQIEQDRIRKEQERQARLEAERLKREAEEREMRERERQRLEQERLQREMEEKARREKEEQARIERERLERERVAREALAAQQAQQAQQQRQRALMEQQQRQQMMNQQQQQQAPYGQQQPQGQPPSYQQSSYQNPSGYQQGQQSGQNQPPNYQQTSHTNPAMQNPSMQQAQQPPAYQQDNSQMNMQQNRQQQYGNQSQQSQQAQQGQYPQQYPQQLNQNQQMNQQQQQRNPFGAQPEMQIGGPKMLMQAKPDEAHAQQYQHTQAQLALSQKEKEMQYLKAKNLQAGQAAGQQQPRFGENPQQNVPGFNRNLPYPQQQQQSQQPGTSQIPNTTPTRPTNPMQGQQQQGGMQNYQNQPVLGQPGPMQTGGQAGQQQQQNQFQRQGMHTTPTKNEMAMRQGQMGGQMGQQGQMGQQQGQMGQQMQNRPAQGGFNQQNQGFQQQGGQQSAQGSFNNQPQNQFAGQQQQMGQNQGQTLQQGQNQFGRQAASNQEAGFQQQPGFNQNPGQNYQRPEQQQQQNQNQWNQQNQQMRPQQPQQPSQQQQNVPFGRNEQQQQFQQSQHQQQNKPAMGQQGFNYQGQQQQGQGFDQSSQQAQQHQNPTHHQQGHMQQQNPQQQQYNQTQQSSQQQQQGNQFPGFSGSSNQARSSNILSQSMEDAGLNQGFQSGNASNQQASSSNQQGNYGMQQGQQNPMQGQMHHQQGQQNQNQQQRSGMGQQGMGQQGGMGQPGMGSQSAMGQHQHGMGRSTMGQPGMQQSGMQQQHGMQQGAQQPAMQQSGMQQHGMSQSGMGQPGMGGMQQQNRNSFGSMGQQGQQSGQQSQQHQQMPQQNQQAQQRQMPGGGVQLPPYSMGQQQQTQQQQPNQQQMDQLRRQQQMQQMARQQAMQQQQGVQQGQPQMQGYGNQGQQQQQFPQMQQHRGQGQGMGGAGQQHQQVPQQQQNQYFQPQQQQDQRMQQQPGGQQQQGHSGQQQNNQYYNPNQQQY
Length3891
PositionKinase
OrganismCaenorhabditis nigoni
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.07
Grand average of hydropathy-0.990
Instability index56.00
Isoelectric point7.91
Molecular weight444525.33
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16190
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            17|    1138.91|      60|      60|    3626|    3685|       1
---------------------------------------------------------------------------
 2743- 2797 (61.72/14.44)	GIPA....A...G.attQQ....QPH...............PGM............Q..HQG.MG..SG.......M....G......AG...MGGmNPTMH.A.PPPYSSSSMNpfanQ.P
 3058- 3105 (62.08/14.57)	G.QQ....S...G....QN....QPPNY....Q.QTSH.tNPAM.........................................qN.PS...MQQ.AQQPP.AYQQDNSQMNMQ....Q.N
 3106- 3153 (69.58/17.21)	RQQQ....Y...G....NQ....SQQSQ....Q.........................aQQG.QYPQQY.......P....Q....Q.LN...QNQ.Q..MN.QQQQ..QRNPFG...aQ.P
 3154- 3231 (48.02/ 9.63)	EMQI....G...GpkmlMQakpdEAHAQ....QyQHTQ.aQLALsqkekemqylkaKN.LQA..GQAAG.......Q....Q....Q.PR...FGE.NPQ...QNVPGFNRN.LP....Y.P
 3232- 3287 (52.16/11.08)	..QQ....Q.........................QQSQ..QPGTsqipnttptrptNP.MQG.QQQQGG.......MqnyqN....Q.PV...LGQ.P...G.PMQTG......G....Q.A
 3288- 3342 (72.77/18.33)	GQQQ....Q...Q....NQ...fQRQGM....H.TTPT..KNEM......amrqgqMG.GQ..MGQQGQ.......M....G....Q........Q.QGQMG.QQMQ.......N....R.P
 3343- 3388 (61.64/14.42)	A..Q....G...G....FN....QQN........QGFQ..Q...................QG..GQQSA.......Q....GsfnnQ.PQnqfAGQ.QQQMG.QNQ........G....Q..
 3389- 3433 (57.97/13.13)	TLQQ....G.........Q....NQFGR....Q.AASN..QEA..................G.FQQQPG.......F....N....QnPG...QNY.QRPEQ.QQQQ.....N.........
 3434- 3468 (49.09/10.00)	..QN....Q...W....NQ....QNQQM....RpQQPQ..QP.....................................................S.QQ....QQNVPFGRNEQ.....Q.Q
 3469- 3498 (55.06/12.10)	QFQQ....S...Q....HQ....QQN..............KPA.............MG.QQG.FNYQ..................................G.QQQQG...........Q..
 3499- 3548 (70.05/17.37)	GFDQ....S...S....QQ...aQQHQ.............NPTH............H..QQGhMQQQNP.......Q....Q....Q.QY...NQT.QQSSQ.QQQQG......N....QfP
 3549- 3595 (52.69/11.27)	GF......S...G....SS....NQ...........AR..SSNI............LS..QS.M.EDAG.......L....N....Q.......GF.QSGNA.SNQQASSSNQQG....N.Y
 3596- 3663 (103.94/29.29)	GMQQ....GqqnP....MQ....GQMHH....Q.QGQQ..NQNQ.......qqrsgMG.QQG.MGQQGG.......M....G....Q.PG...MGS.QSAMG.QHQHGMGRSTMG....Q.P
 3664- 3722 (100.33/28.02)	GMQQ....S...G....MQ....QQHGM....Q.QGAQ..QPAM........qqsgMQ.QHG.MS.QSG.......M....G....Q.PG...MG......GmQQQNRNSFGSMG....Q.Q
 3723- 3783 (74.54/18.95)	G.QQ....S...G....QQ...sQQHQQmpqqN.QQAQ..QRQM............PG.........GGvqlppysM....G....Q.QQ...QTQ.QQQPN.QQQMDQLRR.......Q.Q
 3784- 3838 (73.96/18.75)	QMQQmarqQ...A....MQ....QQQGV....Q.QG....QPQM..........qgYG.NQG.QQQQ...................QfPQ...M...QQHRG.QGQ.GMGGA..G....Q..
 3839- 3886 (73.30/18.52)	..QH...................QQVPQ....Q.QQNQyfQPQQ............QQ.DQR.MQQQPG............G....Q.QQ...QGH.S...G.QQQN....NQYY....N.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     118.43|      20|      20|    2928|    2947|       2
---------------------------------------------------------------------------
 2856- 2873 (22.86/ 7.47)	AREHQERLAREAKI.....rEE...Q
 2934- 2956 (28.71/11.51)	ARLEAERLKREAEE...remRERERQ
 2957- 2978 (22.58/ 7.28)	.RLEQERLQREMEE...karREKEEQ
 2979- 3003 (22.61/ 7.30)	ARIERERLERERVA.realaAQQAQQ
 3004- 3029 (21.68/ 6.66)	AQQQRQRALMEQQQrqqmmnQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      65.45|      16|      19|    2518|    2533|       3
---------------------------------------------------------------------------
 2518- 2533 (26.94/15.07)	EAK.KADEKTTKADDEK
 2540- 2552 (19.76/ 8.71)	DAK.KDNEK...QKEEK
 2558- 2573 (18.75/ 7.80)	SAKaKTDDVTAK.DTEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.33|      40|      42|    2612|    2652|       4
---------------------------------------------------------------------------
 2612- 2651 (72.52/44.90)	ETS.TTR.GRGGGRKRN..SGGRA......TGGS.............RAKRTNSRANANAETA
 2655- 2717 (40.81/17.81)	ETSaTTKaGASGGGSSNyhAAMRAnqppmsNGSSdetkanirnllnrKQEKRNSLADANAAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.51|      34|      61|    2821|    2854|       5
---------------------------------------------------------------------------
 2821- 2854 (62.54/31.17)	EERARIMEEQMHQ....KLAQQQQLIEQQNR....QREARER
 2874- 2898 (22.73/ 6.39)	..........MQ......L.ERQRVIEENNRkmeeQRIQREK
 2899- 2932 (46.24/21.02)	EEAARRLEEQRRRdeeaRLAYQ...IE.QDR....IRKEQER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.87|      32|      42|    2361|    2402|       7
---------------------------------------------------------------------------
 2361- 2392 (53.88/45.09)	FLPIGKLQTSTISYKKYHKRTIRPSAVKSKKF
 2405- 2436 (58.99/29.30)	YLPEEKVKTNAYDHMKNVPDGIQKGGWKFRMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.58|      16|      18|    2574|    2589|       8
---------------------------------------------------------------------------
 2574- 2589 (25.88/15.04)	DTSAPTDAAKAAAAPV
 2594- 2609 (28.70/17.65)	DANKEMDTSTPKPAPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16190 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AFDPKHDGDEMDFSNPTPPEAPPPPPPVDFETSPSASPAPDTDKEDDDGKAKEGGDKAAEKSTDKSAGEKEASEKEKTTDGKKDGDKPAEEKSKKDGKAAEEKKTVDEHLNDLIIPMDVEAEAASKRNSATNSKDDEAEDANKVAGDAPVVEATPAAGTSEKHPEAEVTQVETNDVEMESVDSETNKESTSDPTADKPSNGEEPMEVDDPQKKLPSPSAAAEGDDASKKSKEGEKPDAPAIELVDLEALDDIPLPTDDLMLPDEDEIQVIEKPKHPDADFCEVVEVVEKDKDKTPETAGEGEKGAEKEPEKIPEPIPAVEPVPEPVKTPEKPKTPEPPRLYTAEEIEQLKKDKRR
2) DVFEEFKDPDSPDGSRPASPVEPIPFKKLHKTPPKRVLTDADEFGHIPAQKRKINPKL
3) FYLRPPEVEITKTVEPVADDEETTVVKKPEEESAEKKKDEAKKADEKTTKADDEKKNDETADAKKDNEKQKEEKDKPEDSAKAKTDDVTAKDTEKDTSAPTDAAKAAAAPVAAAPDANKEMDTSTPKPAPVTRETSTTRGRGGGRKRNSGGRATGGSRAKRTNSRANANAETAAAAETSATTKAGASGGGSSNYHAAMRANQPPMSNGSSDETKANIRNLLNRKQEKRNSLADANAAA
4) PALAPIVQPGIPAAGATTQQQPHPGMQHQGMGSGMGAGMGGMNPTMHAPPPYSSSSMNPFANQPHFAAPNPGPITTMAHRSAAAVTPEERARIMEEQMHQKLAQQQQLIEQQNRQREAREREAREHQERLAREAKIREEQMQLERQRVIEENNRKMEEQRIQREKEEAARRLEEQRRRDEEARLAYQIEQD
5) PIDSDDELYIPSDVESLTTPEPEDPEEGPEEDPSKSVPSPTSSAGPASIEDDCWRTRGLVPQTVAKPAPEPVQQPVPQPPPKNLNIKSEPVDLEYEKNFGNPVKSKNFNINIKAEPMDYDEYSTEPPQPLQPPQTFQQRPETPEKEKAPEQPAEPPRWTLAELPKD
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
718
641
2479
2734
437
2927
1072
698
2716
2924
602
3891










Molecular Recognition Features






MoRF SequenceStartStop




1) DVFEE
2) EKEASEKEK
3) FKKLHK
4) LFVYYLI
5) NQYFQPQQQQDQRMQQQ
6) VDLEALDDIPL
7) YYNPNQQQY
641
786
666
707
3849
961
3883
645
794
671
713
3865
971
3891