Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MAQTQTQTPAQTLPQEHIKAIDHLRMRLAGLSTSLHLLQGELAKPQNDPLLAWPQLQKASTNLGQNLDGLASALSAQRQLFTSLHLHPLPNFPAHTQQGLLEQLVRKKLDPRAEAWIEESVNVGKEQSNGVAAGQESGTLTEAEMQDLWSSAMDIHQEVLAPWMEQDLFSDDFTVLERENGVKNVVTGLKRDLADEDDDDEDDGDDDGDKMVEDTVKPDVVQAPAANGLNTSLPPLPLDSMLKFAHGQDVP |
Length | 251 |
Position | Head |
Organism | Cercospora beticola (Sugarbeet leaf spot fungus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Cercospora. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.545 |
Instability index | 38.33 |
Isoelectric point | 4.43 |
Molecular weight | 27529.32 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP16184 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 106.49| 33| 38| 1| 35| 1 --------------------------------------------------------------------------- 1- 35 (48.98/41.41) MAQTQTQtPAQTLPQEHiKAIDHLRMRLAGLSTSL 42- 74 (57.51/38.54) LAKPQND.PLLAWPQLQ.KASTNLGQNLDGLASAL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KMVEDTVKPDV 2) MLKFAHG | 210 241 | 220 247 |
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