<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16182

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFLKACTTNIHAIESVSQVRFALFQFRHNTAPSHTQWSKLQRAIARLRADNVLCAAVGSQVYVFGDSTGDGNAAYQELEADLEVIAQGTVAERAAESATSSPRDALLAAVELSVAHNLSKDPAITHVAPWTWLYGNRRSDEVDEGESMMIKLRARTTPTDGLYLVSDVLPATLQTVGSARCSTDDPVVLAPFGQSARPLVLESGKNLLDGENWRTIVTEMLPTQGLELPRDTQWIPVELLDGTETAWAWPAHLCFTTSVANNQVDATFAEGRDWRRWFISTEEGAIFRNPLAATEDWYKGFAERERAKAAADVFVPTEAPTTGQAPPTMTAEVTPLEADTAVSPSFTQRGAEHLSAMVGIYPTPPDGFAPAQPGLLSAATPSVTQPDPSSSVLGTSPNDSMQPKPSAQQPPPPHDPSELNAAQDDLFGDVGEMGFGDAEIEDADFNFFDEPDDEFTEQPPMETRDVLDESNADAETISAAQPTELALEGDASVLPDASNDDNLLQYELADTTNANIAEKIDTEESSIGARALSEPSIKPKRPLSPFGIREQLLPPPVPASHLQLHADAQSRHTGRRDSSFASINFRNSIRMASMYEPALVAKDAARTKPPPDSVCIALPPARTGPGVKQEVHDTDGYDVDSSDSEEESYDSSSSEADDTDLPPRLPWETRKRKRQLDDDVATYTLNNHMNSHAEEDEVGNVSDAAAKNTMVEVLQQYSSSILLADFGSSLRPSKPTQHPPALLHALQPESMETVAGPLLSLESAYSLTKSDLICVAQLVADQSITANIRSSIGVHDLSGDSELVVPVVTKYLRDQLKRAVRIAVPEALECDLSELALSKESVLRQTNNAGKTPQGQPRPPQRLDSAHIGPDCFTLPSPFLRLRRGRDAWEMLPACIPFWETLGLSPAAGPKHLRAFCVFPFNEDLQRLADHFLGDLGTAYENCKLGTHVHLRNASEVDVHDTFEDGMAPVDLGEEASLEAALKSYATTCSDLGKALSTIAHQESEDRAIVVYILNPFSGEQARQHLCACFWTLFQTYRDNMPRASGERGGSDIFLQLLPISLVAAYDAFVPLDARRMSILAREIYDRCPPTSALQLSDISAPLPNLAAPTVELASMAPKRLGFQLIPEAAADLLYEGSILHLAYACSSDGKWLTASWIDSTGKYQSSSSFCMAGRTFAETAEDVWEHTKTIMAARQVSWRIFVVTQDSAIEASIMHCWRMLAAKPRAQPVCVTMLSIQTEPLLQLLPPYAGLEHAAIGSAENGVLTPASTPQGATFTSSPDVAGHGGNAPLTPAPSDTATSLPADSAADADAQLTDMTDETWGVLLTSKLSGTTQNSSMAHGVLLQRGKVALHDTDQIEMIDKLPSLGVNIHWTIQVKPQGTVDEGSIKQAELTLREVLRMFRGLSLLTKARGLECSVGAFAPLHVATAVMGAAGLDGLLADPEGGSG
Length1449
PositionKinase
OrganismCercospora beticola (Sugarbeet leaf spot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Cercospora.
Aromaticity0.06
Grand average of hydropathy-0.260
Instability index47.49
Isoelectric point4.67
Molecular weight156391.28
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16182
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     380.99|     135|     156|     854|    1005|       1
---------------------------------------------------------------------------
  854-  920 (74.55/50.90)	.....................................................................................................................................................................PQGQPRPPQRLdSAHIGPDCF.TLPSPFLRLRR...GR.DAWEMLPACIPFWETLGLSP.AAGpkhlrAFCVF
  921- 1070 (187.69/137.49)	PFneDLQRLAdhFLGDlgTAYENCKLGTHVHLRnasevDVHDTFED.........GMAPVDLG....EEAS....LEAALKSYATTCSDLGKAL......STIAHQES..............................................edraivvyilnPFSGEQARQ.....HLCA.CFwTLFQTY.RDNM...PR.ASGERGGSDI.FLQLLPISL.VA......AYDAF
 1072- 1168 (79.71/41.04)	PL..DARRMS..ILAR..EIYDRCPPTSALQLS.....DISAPLPNlaaptvelaSMAPKRLGfqliPEAAadllYEGSILHLAYACSSDGKWLtaswidSTGKYQSS..................................................................................................................................
 1226- 1285 (39.04/12.35)	............................................................................................................ssfcmagrtfaetaedvwehtktimaarqvswrifvvtqdsaieasimhcwrmlaakPRAQPVCVTML.SIQTEPLLQ.LLP.PYAGLEHaaiGSaENGVLTPASTPQGATFTSSPdVAG..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.27|      15|      15|     386|     400|       2
---------------------------------------------------------------------------
  386-  400 (27.38/12.13)	QPDP.....SSSVLGTSPND
  410-  426 (22.74/ 8.63)	QPPP...phDPSELNAAQDD
  482-  501 (20.15/ 6.69)	QPTElalegDASVLPDASND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.04|      10|      15|     601|     610|       3
---------------------------------------------------------------------------
  601-  610 (17.53/ 9.00)	VAKDAARTKP
  617-  626 (19.51/10.98)	IALPPARTGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.31|      11|      15|     171|     181|       4
---------------------------------------------------------------------------
  171-  181 (19.96/11.87)	PATLQTVG.SAR
  187-  198 (16.35/ 8.19)	PVVLAPFGqSAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.02|      47|     682|      75|     127|       5
---------------------------------------------------------------------------
   75-  127 (57.69/57.55)	AYQELEADLEVIAQgTVAEraaESATSSPRDAlLAAVELSVAHNLSKdPAITH
  765-  811 (77.32/50.44)	AYSLTKSDLICVAQ.LVAD...QSITANIRSS.IGVHDLSGDSELVV.PVVTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     214.25|      59|     122|     508|     566|       6
---------------------------------------------------------------------------
  507-  565 (96.54/48.13)	YE............LADTTNAN.IAEKIDTEESSI.....GARA..LSEPSIKPKRPLS.PFGIREQLLPPPVPASHLQL
  631-  688 (81.56/39.53)	.E............VHDTDGYD.VDSS.DSEEESY.....DSSSseADDTDLPPRLPWE.TRK.RKRQLDDDVATYTLNN
  689-  749 (36.15/13.46)	H.mnshaeedevgnVSDAAAKNtMVEVLQQYSSSIlladfGS........SLRPSKPTQhPPALLHALQP..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.43|      13|      18|     317|     331|       7
---------------------------------------------------------------------------
  317-  331 (19.26/12.81)	PTEAPtTGqAPPTMT
  336-  348 (22.17/ 7.07)	PLEAD.TA.VSPSFT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.88|      16|      18|     205|     222|       8
---------------------------------------------------------------------------
  205-  222 (24.34/24.86)	GKNLLDGENWrtIVTEML
  226-  241 (29.55/21.58)	GLELPRDTQW..IPVELL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.37|      15|      21|     269|     283|       9
---------------------------------------------------------------------------
  269-  283 (30.01/20.01)	FAEGRDWRRWFISTE
  292-  306 (27.36/17.54)	LAATEDWYKGFAERE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.09|      18|      18|     428|     445|      13
---------------------------------------------------------------------------
  428-  445 (31.96/21.50)	FGDVGEMGFGD.AEIEDAD
  448-  466 (30.13/19.75)	FFDEPDDEFTEqPPMETRD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16182 with Med13 domain of Kingdom Fungi
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