<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16176

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMDHGHRPLGGGTGQRPLPPQRAVSGSHALQQGLKRPAVPSRLNNVRSVSQPGFYVDLTSDAATRQNAAAFTNNGGSLYTSPNVIDLSDDDQARPAKRARTDAHVPPPGEGGVQDPAHRRRPGSPLPPPPVPRLPACMGRSRRPAVDRLARRANGLEPPLCATRLPLPKQVADFAPWNGQHPEDVMTDGVVKGGYYDKPPGPNSTETNSAKPTIWPNLSAKNNMGLQTLSYLFTSVLEKRQALGKCTAPSTFKPPPRVTVTDTKREAWLRDLANPEVPLRKQSRTIPHGIRGKLLMEQCLGKNIAMPRAVWLAKCVGANELRAFRRKGVSGTAAAAGESKWVREWTVQVEFFLESVIAMCGQPEWQSKMDYAVKLATAFYAERLLERDHYLDWIVSSYAQATTERLPIWIILVQLYWKEITSFGRRGRRLAEATLENLQQLTRLDSRVHDSLKARLQKLVMIMAVTNRGCLIIPRSWQKYQHLLTPKTAAPGTPAQNITKRNRRLLAPLMKTPQNTRCPLLTLYGILDAHAHALHVDVGRLATACQAIIPEVDKLIAALLTWSSSVYRTGINRAYLAAKVIAVLASKGLDTDGAILSFLGIPQSVSIVAADVHRVLTELVRENGFSCGRYLQWLITSGAVSGSASPDLATGLLIALPASALPAHLQNTRKSLLHRISEVKDEGSVVSDILGVGIDDSDTASRVRVMQQTESLGAAAKQELADALTAQVEYLVKESILTHRWFCFARDVLEIILDMRALRHLLQMSMTSGDPGILASISDTIDYHRKSFAAMGYLMPMVDDLLEHYRVLRSQQALDRALIISLITLTKPWADKMHLLQSQQILGALPNDLLICEQQTSMAVCSPASDSLVSMQAGSLDSDQEIDAVFASGNTMDEQLMQRVFARIAQRAGKFESEQDHAASKLCAWLTQLRAVDASNFDLLATNHVQACLRSSGDAASSLTLISALVASGCMELETIIGLAQNMKTPASACTMVRLLTATASICVGLGEHEAYRFRVIQQRACQTSADALVPLLVTAMDDNKFPASDPGIITLLLEYTVSRYQVCLRALTSARPSPAFLSNCTKLVTKMLSPSCDEYVSVVGLDAKTIIGLADAISVAQCTMALALLAKKEALRGLPNESTLQPAILDAIVHGSEIWPQLLESAGQDTVRSIYQWAKDQVLVCASLETGPASIDEAKASRNLDILCVAHHAAKDNSKSQIVSSILDRLKELLERLPKEPLGVEHKQYLMALRILLHLCILYACDPTSDREGPRTSRESLLATLCIFLGHPGLQCHQEILEYIHDVASALSDALPAESLTALGHAMLRNGVRDPRLAFILGMINNPDAWLALVSYPQPQPGGGSAQAKALLQRAAQQQQQAQAAGRPGPMSGAGGSAVLQRAMSLRAGQQPQGEPKVVPYTLRRWEMMSDATPSMGDNDTSLSLGLFGARKVY
Length1450
PositionKinase
OrganismCercospora beticola (Sugarbeet leaf spot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Cercospora.
Aromaticity0.05
Grand average of hydropathy-0.106
Instability index48.81
Isoelectric point8.83
Molecular weight157888.06
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16176
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.27|      16|      33|     119|     134|       1
---------------------------------------------------------------------------
  119-  134 (34.18/16.01)	RRPG........SPLPPP.PVPRLP
  141-  165 (20.09/ 6.33)	RRPAvdrlarraNGLEPPlCATRLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.66|      13|      33|     812|     844|       2
---------------------------------------------------------------------------
  795-  811 (19.52/23.24)	PMVDdlleHYRVLRSQQ
  827-  839 (26.14/12.49)	PWAD....KMHLLQSQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.80|      32|      34|     963|     995|       3
---------------------------------------------------------------------------
  963-  995 (50.98/34.54)	AlVASGCMELETI....IGLAQNMKTPASACTMVRLL
  997- 1032 (49.81/29.35)	A.TASICVGLGEHeayrFRVIQQRACQTSADALVPLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.85|      19|      27|    1366|    1384|       4
---------------------------------------------------------------------------
 1366- 1384 (30.23/16.48)	ALLQRAAQQQQQAQAAGRP
 1394- 1412 (34.62/20.06)	AVLQRAMSLRAGQQPQGEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.98|      13|      33|     871|     883|       5
---------------------------------------------------------------------------
  871-  883 (22.06/14.66)	QAGSLDSDQEIDA
  906-  918 (22.92/15.55)	RAGKFESEQDHAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.88|      27|      28|      43|      69|       7
---------------------------------------------------------------------------
   43-   69 (45.26/28.29)	NNVRSVSQPGFYVDLTSDAATRQNAAA
   72-   98 (46.62/29.37)	NNGGSLYTSPNVIDLSDDDQARPAKRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.57|      17|      23|       4|      21|       8
---------------------------------------------------------------------------
    4-   21 (30.30/21.05)	GHRPLGGGTgQRPLPPQR
   25-   41 (31.27/16.60)	GSHALQQGL.KRPAVPSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.00|      69|     491|     549|     770|       9
---------------------------------------------------------------------------
  661-  736 (101.48/220.47)	PAHLQNTRKSLLHRISEVKDEGSVVsdilgVGIDDS...DTASRVRVMQQTESLGAAAKQELADALTAqvEYLVKESIL
 1074- 1145 (108.53/17.13)	PAFLSNCTKLVTKMLSPSCDEYVSV.....VGLDAKtiiGLADAISVAQCTMALALLAKKEALRGLPN..ESTLQPAIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16176 with Med12 domain of Kingdom Fungi
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